Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Ishii, Satoshi; Katsumura, Takafumi; Shiozuka, Chikara; Ooyauchi, Keisuke; Kawasaki, Kunito; Takigawa, Shigenobu; Fukushima, Tamio; Tokuji, Yoshihiko; Kinoshita, Mikio; Ohnishi, Masao; Kawahara, Mika; Ohba, Kohtaro

doi:10.1271/bbb.80324

Cited by 49 publications

(29 citation statements)

References 33 publications

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“…Both serum cytokine levels corresponded to their gene expressions in tissues, but no antiinflammatry effect in mice was observed when extract of Fagopyrum esculentum was given intraperitoneally. Oral administration of the extract of Fagopyrum esculentum also showed protective activity to hepatic injury induced by galactosamine/ LPS treatment [76]. The effects of Fagopyrum esculentum was studied on the release of inflammatory mediator and proximal signal events in F CE RI -mediated RBL-2H3 cell activation.…”

Section: Antiinflammatory Effectmentioning

confidence: 99%

A review on Fagopyrum esculentum: A potential medicinal plant

Al-Snafi¹

2017

IOSRPHR

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Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.

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Section: Antiinflammatory Effectmentioning

confidence: 99%

A review on Fagopyrum esculentum: A potential medicinal plant

Al-Snafi¹

2017

IOSRPHR

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“…Buckwheat sprouts are becoming popular as a health‐promoting food product . Lin et al reported that sprouting greatly improved the nutrient contents of buckwheat, especially total polyphenolics, rutin, quercetin, l ‐ascorbic acid and γ‐aminobutyric acid (GABA) and related appreciable hypolipidemic bioactivity.…”

Section: Other Buckwheat Productsmentioning

confidence: 99%

Hypolipidemic activity of common (Fagopyrum esculentum Moench) and tartary (Fagopyrum tataricum Gaertn.) buckwheat

2014

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Buckwheat grain has well-balanced nutritional value, whereas its digestibility is relatively low. This review summarizes recent advances in studies on the hypolipidemic activity of buckwheat. The most remarkable function is a powerful hypocholesterolemic activity of buckwheat protein in rats, which is far stronger than that of soy protein. The cholesterol-lowering effect is mediated by mechanisms involving higher excretion of fecal sterols and lower digestibility of buckwheat protein. The insoluble fraction of buckwheat protein associates with cholesterol and reduces micelle cholesterol uptake in caco-2 cells. Furthermore, consumption of buckwheat protein suppresses cholesterol-induced gallstones and body fat in rodents. Buckwheat sprouts also have hypolipidemic activity in rats or type 2 diabetic mice. Tartary buckwheat bran extract reduced the serum level of total cholesterol and triglyceride in hyperlipidemic rats. The consumption of buckwheat seed reduced low-density lipoprotein cholesterol in the pastureland Mongolian population. Taken together, buckwheat may be beneficial for prevention of hyperlipidemia.

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“…In addition, biological functions associated with sprouts (Ishii et al, 2008;Kuwabara et al, 2007) and hulls (Kim, Cui, Kang, Kim, & Ham, 2007) have also been reported. Therefore, as buckwheat plant parts other than the seeds have the potential to be effectively utilised as a functional food, we measured the HNA and NA contents of different plant regions (Table 3).…”

Section: Hna and Na Distribution In Buckwheat Plantsmentioning

confidence: 99%