Antioxidant activities and lutein content of 11 marigold cultivars (Tagetes spp.) grown in Thailand

Ingkasupart, Pajaree; Manochai, Benya; Song, Woo Tae; Hong, Jeong Hee

doi:10.1590/1678-457x.6663

Cited by 43 publications

(25 citation statements)

References 29 publications

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“…Generally speaking, flowers of T. erecta showed a great variability regarding the phenolic content. For example, some studies reported higher TPC values than our data [5,23] while others showed lower ones [6,24] and others found values in the same range [25]. The study carried out by Li et al deserves a particular mention [23].…”

Section: Resultsmentioning

confidence: 47%

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

et al. 2018

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Tagetes erecta L. has long been consumed for culinary and medicinal purposes in different countries. The aim of this study was to explore the potential benefits from two cultivars of T. erecta related to its polyphenolic profile as well as antioxidant and anti-aging properties. The phenolic composition was analyzed by LC-DAD-ESI/MSn. Folin-Ciocalteu, DPPH·, and FRAP assays were performed in order to evaluate reducing antiradical properties. The neuroprotective potential was evaluated using the enzymes acetylcholinesterase and monoamine oxidase. Caenorhabditis elegans was used as an in vivo model to assess extract toxicity, antioxidant activity, delayed aging, and reduced β-amyloid toxicity. Both extracts showed similar phenolic profiles and bioactivities. The main polyphenols found were laricitin and its glycosides. No acute toxicity was detected for extracts in the C. elegans model. T. erecta flower extracts showed promising antioxidant and neuroprotective properties in the different tested models. Hence, these results may add some information supporting the possibilities of using these plants as functional foods and/or as nutraceutical ingredients.

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Section: Resultsmentioning

confidence: 47%

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

et al. 2018

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“…Lutein is known for its antioxidant activity. 7 The cytochrome P450 enzymes are the main players in Phase I metabolism and also involved in the oxidation and elimination of a wide array of xenobiotics such as drugs and toxins. 8 A number of therapeutic agents such as quinidine, vinblastine, ergotamine, berberine, and colchicines synthetic agents such as nifedipine and diazepamare the main substrates of CYP3A4.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

Meenapriya¹,

Anitha²,

Lakshmi³

2018

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Background: Lutein is a carotenoids vitamin rich in many fruits and vegetables and also available in multivitamin products. It is consumed for its effect on eye disease, cancer, diabetes and other health conditions. Recently, herbal preparations are increasingly used in healthcare systems and concomitant administration of synthetic medications may cause pharmacokinetic or pharmacodynamic interactions leading to very serious medical problems. Understanding the ability of herbal extracts and preparations to modulate the metabolizing enzymes can help the health system for proper treatment of patients and thereby can avoid many adverse effects associated with it. The aim of the study was to find the effect of lutein isolated from Tagetes erecta L on cytochrome P450 isoform CYP3A4. Materials and Methods: The different concentrations of lutein (5-100µg/ml), potassium phosphate buffer, CYP450 reagent and substrate 7-Benzyloxy-4-trifluoromethylcoumarin (BFC) were added to a 96-well plate. The fluorescent intensities of the products were measured by Perkin Elmer Enspire fluorescence reader using an excitation and emission wavelength of 405 nm and 460 nm, respectively to examine the effect of lutein on Cytochrome P 450 isoform CYP3A4 and the IC 50 was calculated by plotting concentrations of lutein against the corresponding percent inhibition. Results: All the tested concentrations of lutein showed potent inhibition against CYP3A4 in a dose-dependent manner. The IC 50 value was found to be 35.27µg/ml. Conclusion: The inhibitory effect of lutein indicates the possibilities of herb-drug interaction if it is co-administered with prescribed drugs that are normally metabolised by CYP3A4 enzyme.

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“…Berbagai jenis tanaman dapat diolah menjadi teh herbal, salah satunya yaitu bunga gumitir. Bunga gumitir merupakan salah satu bagian dari tanaman gumitir (Tagetes erecta L.) yang mempunyai kandungan komponen bioaktif, yaitu fenol (25,77 mg GA/g), flavonoid (20,59 QT/g), dan karotenoid berupa lutein (20,59 mg LT/g) (Ingkasupart et al, 2015). Senyawa polifenol yang ditemukan pada bunga gumitir adalah golongan flavonol yaitu laricitrin dan glikosidanya (Moliner et al, 2018).…”

Section: Pendahuluanunclassified

Aktivitas Antioksidan dan Evaluasi Sensoris Teh Herbal Bunga Gumitir (Tagetes erecta L.)

Kusuma¹,

Ratna²,

Kalalinggi³

et al. 2020

JITP AGROTECHNO

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Bunga gumitir memiliki manfaat yang baik bagi kesehatan karena mengandung komponen bioaktif berupa flavonoid, fenol, dan karotenoid berupa lutein sehingga sangat berpotensi digunakan sebagai teh herbal. Penelitian ini bertujuan untuk mendapatkan teknik pengeringan teh herbal bunga gumitir yang tepat sehingga menghasilkan karakteristik teh herbal bunga gumitir dengan komponen bioaktif dan antioksidan yang tinggi serta sensoris yang baik. Pengeringan dilakukan dengan 5 teknik yang berbeda yaitu pengeringan matahari, pengeringan oven, pengeringan dingin, pengeringan udara, dan pengeringan sangrai. Parameter yang diamati meliputi kadar air, total fenol, total flavonoid, aktivitas antioksidan (IC50) serta pengujian sensoris air seduhan teh herbal bunga gumitir (warna, aroma, rasa, dan penerimaan keseluruhan). Hasil penelitian menunjukkan bahwa pengeringan dingin mampu menghasilkan teh herbal dengan karakteristik terbaik yaitu kadar air sebesar 6,86%, total fenol sebesar 83,88 mg GAE/g ekstrak, total flavonoid sebesar 373,06 mg QE/g ekstrak, nilai IC50 sebesar 257,65 mg/L, karakteristik sensoris paling disukai dengan rasa agak khas bunga gumitir, rasa tidak asam, dan berwarna merah kekuningan. Gumitir flower had good benefits for health because their bioactive components contain flavonoids, phenols, and carotenoids like lutein so that gumitir flower were potentially used as herbal tea. The research was conducted to obtain the appropriate gumitir flower tea drying technique to produced the characteristics of gumitir herbal tea with high bioactive and antioxidant components and good sensory. Drying were carried out with 5 different techniques, namely sun drying, oven drying, cold drying, air drying, and roasting drying. Parameters observed included water content, total phenol content, total flavonoid content, antioxidant activity (IC50), and sensory testing of gumitir flower herbal tea (color, aroma, taste, and overall reception). The results showed that cold drying was able to produced herbal tea with the best characteristics with water content was 6.86%, total phenol content was 83.88 mg GAE/g extract, total flavonoid content was 373.06 mg QE/g extract, IC50 was 257.65 mg/L, sensory characteristics were most preferred with a rather typical taste of gumitir flower, not sour and yellowish red.

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Antioxidant activities and lutein content of 11 marigold cultivars (Tagetes spp.) grown in Thailand

Cited by 43 publications

References 29 publications

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

Aktivitas Antioksidan dan Evaluasi Sensoris Teh Herbal Bunga Gumitir (Tagetes erecta L.)

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