Antioxidant activities and total phenolic content (TPC) were analyzed in ethanol extracts of 11 marigold cultivars grown in Thailand. Antioxidant activity assays performed in this study were the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity, ferric ion reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, oxygen radical absorbance activity (DRAC), and superoxide anion radical scavenging activity (SRSA) assays. 'Dptiva Drange' showed the best activity in the DRAC assay and in % SRSA, as well as the highest content of lutein (20.59 mg), gallic acid (25.77 mg), and quercetin (12.61 mg) per gram dry marigold petal among the 11 cultivars. Furthermore, 'Dptiva Drange' showed the highest lutein yield per plant, as compared to other cultivars. In contrast, 'Rodeo Gold' showed the highest activity by ABTS testing (0.92 mmol of trolox/g dry sample), as well as an 89.90% inhibition of DPPH. Lutein content showed a positive correlation with TPC and all antioxidant activity assays. In conclusion, 'Dptiva Drange' and 'Rodeo Gold' could be utilized as a good lutein source for functional food products and cosmetics.Keywords: marigold cultivars; antioxidant activity; phytochemical.Practical Application: Two marigold cultivars grown in Thailand showed high antioxidant activity among 11 cultivars tested.

(2014) Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury, Animal Cells and Systems, 18:2, 93-100, DOI: 10.1080DOI: 10. /19768354.2014 To link to this article: https://doi.org/10. 1080/19768354.2014 Cerebral ischemia is clinically characterized by a partial functional neurological deficit, which represents one of the leading causes of death. This study aimed to determine whether rice bran extract (RB), ferulic acid (FA), or rice bran extract supplemented with FA (RB + FA) promote functional recovery from ischemic injury. Focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in rats. Four groups were studied, including (1) vehicle group, (2) RB 5%, 10%, and 20% groups, (3) FA group, and (4) RB + FA group. Animals were injected with RB or FA once a day for 3 days after MCAO. In this study's results, the RB 20% and FA groups significantly improved neurological functions compared with the vehicle group. The RB + FA group produced more recovery from functional deficits than the other groups. Moreover, the RB 20%, FA, and RB + FA groups enhanced the antiapoptotic effect in the cortex and neural cell densities in the hippocampal DG and CA1. The RB 20%, FA, and RB + FA groups stimulated not only the expression of neurotrophic factor and antioxidant genes but also neuronal nuclei (NeuN), synaptophysin, and glutamic acid decarboxylase 67 (GAD67) proteins. Our finding indicates that the combination of RB + FA treatment showed the most synergic effect in functional recovery with ischemic brain through the stimulation of the nuclear factor-E2-related factor 2, brain-derived neurotrophic factor NeuN, SYP, and GAD67 expressions.