Antioxidant abietane diterpenoids from Salvia barrelieri

Kabouche, Ahmed; Kabouche, Zahia; Öztürk, Mehmet; Kolak, Ufuk; Topçu, Gülaçtı

doi:10.1016/j.foodchem.2006.07.021

Cited by 104 publications

(71 citation statements)

References 31 publications

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“…Considering structure of the two compounds, glochidone and rosmarinic acid, the main similarity is the presence of an enone moiety which is responsible for their anticholinesterase activity. However, observation of high lipid peroxidation inhibitory activity of rosmarinic acid should be the presence of the two ortho hydroxyl groups in its structure (Kabouche et al, 2007). A study in a literature published before (Orhan et al, 2008 ) supports high anticholinesterase activity of rosmarinic acid we have observed in this work.…”

Section: Antioxidant and Anticholinesterase Activitiessupporting

confidence: 80%

“…They are also being used as spices and tea throughout the world since ancient times. They posses antioxidant, antibacterial, antitumor, cardioactive and antidiabetic activities (Ulubelen, 2003;Kabouche et al, 2007). Antioxidant activity of Lamiaceae (Labiatae) plants which are widely grown in Turkey were also investigated by our group (Kolak et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

et al. 2015

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The methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), b-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (b-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes.Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.

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Section: Antioxidant and Anticholinesterase Activitiessupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

et al. 2015

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“…Antioxidant activity of abietane diterpenoids such as carnosol, isorosmanol, carnosic acid, rosmanol, epirosmanol and galdosol from Salvi officinalis and inuroyleanol from S.barrelieri are reported in the literature. [16][17] Antibacterial activity of abietic acid was tested against six pathogenic bacteria and most sensitive strains were Klebsiella pneumoniae and Escherichia coli followed by Staphylococcus aureus and Pseudomonas aeruginosa. The least activity of the compound was observed against Proteus mirabilis and Proteus vulgaris ( Table 3).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, antibacterial and antiacetylcholinesterase activities of abietic acid from Isodon wightii (Bentham) H. Hara

Ramnath¹,

Thirugnanasampandan²,

Mathusalini³

et al. 2015

Free Rad. Antiox.

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Objective:Isodon is an important genus of the family Lamiaceae which contains diterpenoids of diverse functionalities. The present study attempted with isolation, structure elucidation and bioactivity evaluation of isolated compound from the leaves of Isodon wightii (Bentham) H. Hara. Methods: Petroleum ether extract of powdered leaves was obtained and concentrated in vacuo at 45ºC. Compound was isolated using silica gel column chromatography (60-120 mesh). Antioxidant activity of isolated compound was tested for DPPH free radical and hydroxyl radical scavenging, inhibition of linoleic acid peroxidation and metal ion chelation activities. Antibacterial activity was tested against six pathogenic bacteria by micro broth dilution method and in vitro antiacetyl cholinesterase activity of isolated compound was also studied. Results: Abietane diterpenoid, abietic acid was isolated from the leaves of I. wightii and the structure has been elucidated on the basis of spectroscopic analysis. Abietic acid isolated from petroleum ether extract of leaves showed moderate DPPH free radical, hydroxyl radical scavenging and less inhibition of linoleic acid peroxidation and metal ion chelating activities. Antibacterial activity of abietic acid against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Proteus vulgaris and Staphylococcus aureus was found in the range of 340-980 µg/mL. Antiacetylcholinesterase activity of abietic acid was less when compared with positive control. Conclusion: Abietic acid showed concentration dependent antioxidant, antibacterial and antiacetylcholinesterase activities.

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“…Most Salvia species are rich in essential oils, and various biologically active monoterpenoid/sesquiterpenoid have been reported in them possessing diverse biological activities such as antioxidant [8,9], anti-inflammatory [9,10], analgesic [11], anticonvulsant, anti-ulcerogenic, tranquillizing activities [12] and antibacterial activities [13]. Furthermore, the Salvia species, often pleasantly aromatic plants of potential economic interest, comprise the majority of the essential oil rich genera of the Lamiaceae, and particularly tend to accumulate monoterpenoid-rich essential oils.…”

Section: Introductionmentioning

confidence: 99%

ESSENTIAL AND FIXED OIL CHEMICAL COMPOSITIONS OF THE SEEDS FROM THE ENDEMIC SPECIES Salvia Sharifii RECH. F. & ESFAND

Alipour-Gougeh

Asgarpanah

2015

J. Chil. Chem. Soc.

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The essential oil content in the seeds of Salvia sharifii growing wild in south of Iran was found to be 0.2% (v/w). The essential oil was analyzed by GC and GC-MS. Twenty eight constituents, representing 85.0 % of the seeds essential oil were identified. The major components of the S. sharifii seeds essential oil were identified as sclareol (21.9%) and n-decane (17.3%). The fixed oil content and fatty acid composition of the seeds were also analyzed in order to determine their potential for human or animal consumption. The oil content in these edible seeds was found to be 19.9 %. The oil was analyzed by GC and GC/MS and five fatty acids identified which constituted 88.0 % of the oil. The main fatty acids of the oil were characterized as linoleic acid (39.7%) and linolenic acid (36.7%).

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Antioxidant abietane diterpenoids from Salvia barrelieri

Cited by 104 publications

References 31 publications

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Antioxidant, antibacterial and antiacetylcholinesterase activities of abietic acid from Isodon wightii (Bentham) H. Hara

ESSENTIAL AND FIXED OIL CHEMICAL COMPOSITIONS OF THE SEEDS FROM THE ENDEMIC SPECIES Salvia Sharifii RECH. F. & ESFAND

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