Antiosteopenic Effect of Buffalo Milk Casein-Derived Peptide (NAVPITPTL) in Ovariectomized Rats

Reddi, Srinu; Mada, Sanusi Bello; Kumar, Naveen; Kumar, Rohit; Ahmad, Naseer; Karvande, Anirudh; Kapila, Suman; Kapila, Rajeev; Trivedi, Ritu

doi:10.1007/s10989-018-9763-0

Cited by 14 publications

(7 citation statements)

References 53 publications

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“…Administration of collagen peptides in postmenopausal women with reduced BMD was consistent with BMD improvement [ 60 ]. Some dairy components, for example, milk casein-derived peptide, also possess osteoprotective activity by reducing RANKL, IL-6 and TNF-α expression [ 61 ]. Seafood bioactive peptides, which can act as stimulators and inhibitors of bone formation and resorption, respectively, are considered another source for the prevention of osteoporosis due to immunomodulatory, antioxidant, antihypertensive, osteoprotective and antimicrobial properties [ 56 , 62 ].…”

Section: Macronutrients and Osteoporosismentioning

confidence: 99%

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

et al. 2022

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Osteoporosis is considered an age-related disorder of the skeletal system, characterized primarily by decreased bone mineral density (BMD), microstructural quality and an elevated risk of fragility fractures. This silent disease is increasingly becoming a global epidemic due to an aging population and longer life expectancy. It is known that nutrition and physical activity play an important role in skeletal health, both in achieving the highest BMD and in maintaining bone health. In this review, the role of macronutrients (proteins, lipids, carbohydrates), micronutrients (minerals—calcium, phosphorus, magnesium, as well as vitamins—D, C, K) and flavonoid polyphenols (quercetin, rutin, luteolin, kaempferol, naringin) which appear to be essential for the prevention and treatment of osteoporosis, are characterized. Moreover, the importance of various naturally available nutrients, whether in the diet or in food supplements, is emphasized. In addition to pharmacotherapy, the basis of osteoporosis prevention is a healthy diet rich mainly in fruits, vegetables, seafood and fish oil supplements, specific dairy products, containing a sufficient amount of all aforementioned nutritional substances along with regular physical activity. The effect of diet alone in this context may depend on an individual’s genotype, gene-diet interactions or the composition and function of the gut microbiota.

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Section: Macronutrients and Osteoporosismentioning

confidence: 99%

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

et al. 2022

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“…Ovariectomized rats have been reported to mimic the physiological features of osteoporosis in postmenopausal women such as weight gain, decrease in serum estrogen level, increased oxidative stress, rapid bone turnover, and subsequently low bone mineral density. 26,27 This is because estrogen is directly involved in energy metabolism and its receptors are also expressed in visceral and subcutaneous adipocytes. 28 Chrysin belong to the GRAS (generally regarded as safe) group of compounds and a previous report on toxicological evaluation of chrysin in rats revealed its LD 50 as 4350 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico

et al. 2021

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Background Evidences are beginning to accrue that flavonoids, particularly phytoestrogens, could have beneficial effects against several age-related diseases linked to estrogen deficiency including postmenopausal osteoporosis. Methods In this study, the effect of chrysin on selected bone-remodeling markers in ovariectomized rats and its estrogen-like activity in silico were investigated. Results The data indicated that administration of chrysin at 50 mg/kg and 100 mg/kg for 6 weeks to OVX rats significantly ( p < 0.05) prevented body weight gain and partially reverse uterine weight loss. In addition, treatment of OVX rats significantly ( p < 0.01) increased femur dry weight, femur ash weight, bone ash calcium, and phosphorous levels in a dose-dependent manner. However, there was significant ( p < 0.001) decline in serum estradiol level in all OVX rats compared to the sham-operated group. Interestingly, administration of chrysin significantly ( p < 0.05) reversed the reduction of estradiol induced by ovariectomy compared to untreated OVX rats. Moreover, administration of chrysin to OVX rats significantly ( p < 0.05) suppressed excessive elevation of bone-remodeling markers expression compared to untreated OVX rats. Similarly, molecular docking analysis revealed that chrysin interacts with both α and β estrogen receptors with exothermic binding energies of −229.83 kcal/Mol and −252.72 kcal/Mol, respectively, and also fits perfectly into the active site of both α and β estrogen receptors. Conclusion This study demonstrated that chrysin exhibits potential antiosteoporotic effects against bone loss in OVX rats through enhanced bone mineral contents and preventing excessive elevation of bone-remodeling markers and bone-resorbing cytokine.

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“…Among these peptides, NAVPITPTL peptide markedly increased osteoblast cells differentiation via activation of pAkt signaling pathway (Reddi et al, 2016b). Besides, peptide VLPVPQK exhibited antiosteoporotic effects via inhibition of oxidative damage and bone-resorbing cytokines production in OVX rats as demonstrated in Table1 (Reddi et al, 2019;Huttunen et al, 2008). The proposed possible mechanisms of bioactive peptides against postmenopausal osteoporosis have been shown in Fig.…”

Section: Milk-derived Peptides With Antiosteoporotic Effects In Vitromentioning

confidence: 92%

Milk-Derived Bioactive Peptides With Antiosteoporotic Effect: A Mini Review

Mada

Abaya²,

James

et al. 2020

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Postmenopausal osteoporosis is a global health problem characterized by decreased in bone mineral density (BMD) and progressive deterioration of microarchitecture and subsequent increase in bone fragility and susceptibility to fracture. More than 200 million people suffer from osteoporosis worldwide with about 8.9 million fractures and the prevalence rate of osteoporosis is expected to increase significantly in the future because of increased in life expectancy and aging population. Milk-derived bioactive peptides from cow, goat, sheep, buffalo, and camel exhibit several potential health promoting effect including antiosteoporosis, antihypertensive, antioxidative, antithrombotic, immunomodulatory and anti-inflammatory effects. Epidemiological and intervention studies have shown that milk and milk-derived peptides prevented bone loss in pre- and postmenopausal women. Moreover, quite a lot of studies have reported that milk-derived bioactive peptides can induce osteoblast cell proliferation, differentiation and also prevented bone loss in osteoporotic rats model. Thus, milk-derived peptides exhibits beneficial effect against bone-related diseases and can be of particular interest towards prevention and management of postmenopausal osteoporosis. Hence, the present review summarizes various studies using ISI, SCOPUS and PubMed indexed journals to elucidate the potential role of milk-derived bioactive peptides with in vitro and in vivo antiosteoporotic property

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Antiosteopenic Effect of Buffalo Milk Casein-Derived Peptide (NAVPITPTL) in Ovariectomized Rats

Cited by 14 publications

References 53 publications

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico

Milk-Derived Bioactive Peptides With Antiosteoporotic Effect: A Mini Review

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