Antiobesity effect of ethanolic extract of Ramulus mori in differentiated 3T3-L1 adipocytes and high-fat diet-induced obese mice

Antiobesity effect of Brassica juncea cultivated in Jeongseon with optimized sinigrin content using 3T3‐L1 adipocytes

“…ACC is an enzyme that controls the adipogenesis pathway and contributes to the overall control of energy metabolism (Brownsey et al, 2006). It is inactivated by phosphorylation, and consequently, inhibiting the activity of ACC means that lipid production can be inhibited, and obesity can be prevented (Park et al, 2020). FAS is a key enzyme involved in fatty acid biosynthesis, and it has been reported that sinigrin effectively reduces the expression level of FAS (Lee et al, 2018).…”

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

“…Among the anti-obesity effects of Juniperus communis [ 104 ], Ramulus mori [ 111 ], Vibrunum opulus [ 106 ], Paullinia cupana [ 96 ], Peucedanum japonicum [ 23 ], Aster yomena [ 97 ], Prunus salicina [ 98 ], Eclipta alba [ 99 ], and Polygonum cuspidatum [ 92 ] evaluated on 3T3-L1 cells, Eclipta alba showed the highest activity as it decreased the expression of PPARα (1.9 fold), C/EBPα (1.8 fold), FAS (1.4 fold) and FABP4 (1.8 fold) and also decreased the concentration of lipids in terms of cholesterol and triglycerides in these adipocytes. The above-described plants regulated the transcription factors and lipid accumulation in 3T3-L1 adipocytes.…”

“…Nanoencapsulation of quercetin with a succinyl chitosan alginate shell [ 124 ] and PLGA [ 128 ] in rat models revealed that the serum lipid profile and glucose level were regulated after the induction of these nanoencapsulated structures. On the other hand, quercetin, being one of the chemical constituents in extracts of different plant parts—flowers of Capsicum annuum [ 94 ], plums of Prunus salicina [ 98 ], leaves of Vitis vinifera [ 100 ], fruits of Rhus coriaria [ 100 ], leaves of Cosmos cadatus Kunth [ 78 ], fruits of Malus prunifolia [ 102 ], fruits of Malus huphenesis [ 102 ], Hibiscus sabdariffa [ 103 ], Solenostemma argel [ 103 ], and Vibrunum opulus [ 105 ], twigs of Ranulus mori [ 111 ], leaves of Nelumbo nucifera [ 81 ], soybean embryo and enzymatically modified Isoquercetin [ 115 ]—has contributed to obesity management as mentioned above.…”

Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial

“…Mulberry ( Morus alba L.) is a well‐known medicinal plant, the most famous species of the genus Morus and widespread in China (Jiao et al., 2020), Japan (Jiao et al., 2020), and Korea (Park et al., 2020). 1‐Deoxynojirimycin (DNJ), a rich ingredient in the mulberry and an inhibitor of α‐glucosidase, which inhibits the elevation of postprandial blood glucose (Wang, Zhao, et al, 2018).…”

“…Mulberry (Morus alba L.) is a well-known medicinal plant, the most famous species of the genus Morus and widespread in China (Jiao et al, 2020), Japan (Jiao et al, 2020), and Korea (Park et al, 2020).…”