Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study

Leal, Luzia Kalyne Almeida Moreira; Ferreira, Anderson A.; Bezerra, Gabriela A. M.; Matos, F. J. A.; Viana, G. S. B.

doi:10.1016/s0378-8741(99)00165-8

Cited by 168 publications

(127 citation statements)

References 15 publications

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“…Alcoholic extracts confer protection against snake venom (Mors et al 1989). It is antiinflammatory (Chandra et al 1987), a bronchodilator (Leal et al 2000) and antimycobacterial (Al-Shamma & Mitscher 1979). Plant powder counteracts an increase of liver weight (Chandra et al 1987).…”

Section: Eclipta False Daisy (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

318

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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Section: Eclipta False Daisy (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

318

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show abstract

“…Many of the Caatinga plant species are used by native communities as firewood (Ramos et al 2008), in carpentry (owing to their recognized durability), as seasoning (Canuto et al 2012), or in folk medicine to treat several diseases (Leal et al 2000;Albuquerque et al 2007;Alviano et al 2008;Cartaxo et al 2010;Canuto et al 2012). The great diversity of the Caatinga vegetation is underexploited, and few searches for active biological substances, including those with insecticidal or repellent activity, have been conducted (Almeida et al 2005;Albuquerque et al 2007).…”

mentioning

confidence: 99%

Larvicidal Activity of Essential Oils From Brazilian Croton Species Against Aedes Aegypti L

Morais

Cavalcanti

Bertini

et al. 2006

Journal of the American Mosquito Control Association

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“…Like other medicinal plants containing coumarin (1) such as Justicia pectoralis, Pterodon polygaliflorus, Hybanthus ipecacuanha and Eclipta alba, A. cearensis, also has a relaxing activity on isolated guinea pig tracheal muscles (Leal et al, 2000). Confirming this as particular effect, it was recently (Leal et al, 2006) demonstrated the relaxant action of the isokaempferide (2).…”

Section: Pharmacology Of a Cearensismentioning

confidence: 93%