Larvicidal Activity of Essential Oils From Brazilian Croton Species Against Aedes Aegypti L

Morais, Selene Maia de; Cavalcanti, Eveline Solon Barreira; Bertini, Luciana Medeiros; Oliveira, Carla Loane L.; Rodrigues, Jarson Raimundo B.; Leal‐Cardoso, J. H.

doi:10.2987/8756-971x(2006)22[161:laoeof]2.0.co;2

Cited by 87 publications

(51 citation statements)

References 21 publications

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“…Also this phenylpropanoid was highly effective in the control mosquito larvae in other studies, e.g., Aedes aegypti (Chantraine, et al 1998;Morais, et al 2006), Ochlerotatus caspius (Knio, et al 2008) and other insects, e.g., the cockroach Blattella germanica (Chang, et al 2002), the beetle Zabrotes subfaciatus (Silva and Câmara, 2007). Besides, anethol also repelled Culex pipiens mosquitoes (Lima, et al 2008) and the aphid Brevicoryne brassicae (Santos, et al 2001).…”

Section: Resultsmentioning

confidence: 84%

“…Essential oils of many Brazilian plants display larvicidal activity, e.g., Ocimum americanum, Ocimum gratissimum (Cavalcanti, et al 2004), Croton zehntneri (Morais, et al 2006), including Piper species (Morais, et al 2007), therefore, in the present study, essential oils of three Piper species commonly found in Amazon region, Brazil were tested as larvicides against the dengue vector, A. aegypti.…”

Section: Introductionmentioning

confidence: 97%

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Essential oils of leaves of Piper species display larvicidal activity against the dengue vector, Aedes aegypti (Diptera: Culicidae)

Santana¹,

Trindade²,

Stábeli³

et al. 2015

Rev. bras. plantas med.

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ABSTRACT:The mosquito Aedes aegypti is the vector of the dengue virus, an endemic arbovirus from tropical and subtropical regions of the world. The increasing resistance of mosquitoes to commercial insecticides impairs regular control programs; therefore, chemical prospecting originating from the Amazonian flora is promising for potential new insecticides. Several Piper species are, notably, rich in phenylpropanoids and terpenoids, substances with proven insecticidal activity. The composition and the larvicidal activity of three Piper species against A. aegypti were evaluated. Essential oils were extracted by hydrodistillation in a modified Clevenger apparatus and analyzed by GC/MS. The major components found in Piper arboreum were germacrene D (31.83%) and bicyclogermacrene (21.40%); in Piper marginatum: (E)-methyl isoeugenol (27.08%), (E)-anethole (23.98%) and (Z)-methyl isoeugenol (12.01%); and in Piper aduncum: (E)-isocroweacin (29.52%) and apiole (28.62%) and elemicin (7.82%). Essential oils from the Piperaceae species studied resulted in Lethal Concentrations (LC 50 ) of 34-55 ppm, while LC 90 was higher than 100 ppm, except for P. marginatum (85 ppm).Key words: Vector control; Essential oil; Piperaceae; Aedes aegypti. RESUMO: Óleo essencial da folha de espécies de Piper exibem atividade larvicida contra o vetor da dengue Aedes aegypti (Diptera: Culicidae). O mosquito Aedes aegypti é o vetor do vírus da dengue, um arbovírus endêmico em regiões tropicais e subtropicais do mundo. A crescente resistência dos mosquitos aos inseticidas comerciais prejudica programas regulares de controle, portanto, a prospecção química proveniente da flora amazônica surge como alternativa promissora para novos inseticidas. Várias espécies de Piper são notavelmente ricas em fenilpropanóides e terpenóides, substâncias com atividade inseticida comprovada. A composição e atividade larvicida de três espécies de Piper sobre A. aegypti foi avaliada. Os óleos essenciais foram extraídos por hidrodestilação em Clevenger modificado e analisado por GC/MS. Os principais componentes encontrados em Piper arboreum foram germacreno D (31,83%) e biciclogermacreno (21,40%); Piper marginatum: (E)-metilo de isoeugenol (27,08%), (E)-anetole (23,98%) e (Z)-methyl isoeugenol (12,01%), e Piper aduncum: (E)-Isocroweacin (29,52%), apiol (28,62%) e elemicin (7,82%). Os óleos essenciais a partir das espécies de Piperaceae estudadas resultou em concentrações letais (CL 50 ), 34-55 ppm, enquanto que CL 90 foi superior a 100 ppm, com excepção para P. marginatum (85 ppm).

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Section: Resultsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 97%

Essential oils of leaves of Piper species display larvicidal activity against the dengue vector, Aedes aegypti (Diptera: Culicidae)

Santana¹,

Trindade²,

Stábeli³

et al. 2015

Rev. bras. plantas med.

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“…Em termos industriais, são utilizados em aromatizantes e perfumes (Buchanan et al, 2000). Em termos farmacológicos possuem uma grande gama de propriedades medicinais como antibacteriana (Suarez et al, 2005;Siminionato et al, 2007;, antisséptica, antihelmíntica, anti-inflamatória (Santos et al, 2005), anticâncer (Sylvestre et al, 2006;Compagnone et al, 2010), antinociceptiva (Abdon et al, 2002;Santos et al, 2005), antioxidante (Agnaniet et al, 2005;Morais et al, 2006;Simionatto et al, 2007;Mohamed et al, 2009), carminativa, expectorante, fungicida (Souza et al, 2006), gastoprotetora (Santos et al, 2005), inseticida , larvicida (Lima et al, 2006;Torres et al, 2008) e vasorrelaxante (Magalhães et al, 2008 Alguns monoterpenos são notavelmente diferenciados. Carvacrol, timol e ρ-cimeno são monoterpenos fenólicos.…”

Section: óLeos Voláteisunclassified

“…Possui atividades biológicas e farmacológicas, como imunomoduladora (Ziaei et al, 2010) e antibacteriana (Limberger et al, 2004;Alcantara et al, 2010). Em Croton já foi detectado em C. matourensis (Compagnone et al, 2010), C.zambesicus (Usman et al, 2009), C. palanostigma (Brasil et al, 2009), C. urucurana (Simionatto et al, 2007) C. argyrophylloides (Lima et al, 2006;Morais et al, 2006), C. sonderianus (Lima et al, 2006) e C. oligandrum (Agnaniet et al, 2006). O espatulenol foi detectado no óleo volátil foliar de 70% das espécies estudadas, com destaque para C. catamarcensis, com 43,3% do total identificado (Tabela 05).…”

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Análise de terpenóides de espécies de Croton sect. Lamprocroton (Mull. Arg.) Pax (Euphorbiaceae)

Feliu¹

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Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole

Bezerra

Filho

Alves

et al. 2009

Chemistry & Biodiversity

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Croton regelianus Muell. Arg., popularly known as 'velame-de-cheiro', is a native plant from the Northeast of Brazil used in folk medicine to treat diseases of different kinds, including malignant tumors. In this study, the in vitro and in vivo antitumor effects of the essential oil from the leaves of C. regelianus and ascaridole, one of the main constituents, were investigated. In vitro, the essential oil and ascaridole displayed cytotoxicity, showing IC(50) values in the range of 22.2 to 48.0 microg/ml in HL-60 and SF-295 cell lines for the essential oil, and 6.3 to 18.4 microg/ml in HL-60 and HCT-8 cells lines for ascaridole, respectively. The in vivo study, using sarcoma 180 as a tumor model, demonstrated inhibition rates of 28.1 and 31.8% for essential oil, at the 50 and 100 mg/kg, while ascaridole inhibition rates were 33.9% at 10 mg/kg and 33.3% at 20-mg/kg doses. Histopathological examination showed that the organs were only weakly affected by the treatment. In conclusion, ascaridole has an interesting antitumor activity in sarcoma 180 murine model, probably related to the described cytotoxic activity, and, moreover, its presence in the essential oil from the leaves of C. regelianus could explain, at least in part, the ethnopharmacological use of this plant in the treatment of cancer.

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Larvicidal Activity of Essential Oils From Brazilian Croton Species Against Aedes Aegypti L

Cited by 87 publications

References 21 publications

Essential oils of leaves of Piper species display larvicidal activity against the dengue vector, Aedes aegypti (Diptera: Culicidae)

Essential oils of leaves of Piper species display larvicidal activity against the dengue vector, Aedes aegypti (Diptera: Culicidae)

Análise de terpenóides de espécies de Croton sect. Lamprocroton (Mull. Arg.) Pax (Euphorbiaceae)

Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole

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