Antinociceptive, Anti-Inflammatory and Antipyretic Properties of the Aqueous Extract of <i>Bauhinia purpurea </i>Leaves in Experimental Animals

Abstract

Objective: The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models. Materials and Methods: The air-dried, powdered leaves (≈20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The crude dried extract (≈2.4 g) was prepared in doses of 6.0, 30.0 and 60.0 mg/kg, and subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests), anti-inflammatory (carrageenan-induced paw edema test) and antipyretic (brewer’s yeast-induced pyrexia test) assays. Results:The results obtained indicate that the extract possessed significant (p < 0.05) antinociceptive, anti-inflammatory and antipyretic activities, which were not dependent on the doses of extract used. The highest concentration of extract was less effective as an anti-inflammatory and an antipyretic agent. Conclusion: This study showed that the aqueous extract of B. purpurea leaves possesses potential pharmacological activities that require further investigation and, thus, confirms the folklore use of the plant in the treatment of ailments associated with pain and inflammation.

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

“…One of the plants traditionally used to treat gastric ulcer is Bauhinia purpurea L. (Fabaceae), which is native of southern Asia, southeast Asia, Taiwan, and China. In Malaysia, the tree is known as 'tapak kerbau' or 'tapak kuda' , while in India, it is known as 'kachnar' or 'khairwal' (Zakaria et al, 2007). The root, stem, bark, and leaf of B. purpurea are also reported to be used in the treatment of jaundice, leprosy, cough, pain, fever, ulcers, stomach cancer, rheumatism, convulsions, delirium, and septicaemia (Chopra et al, 1956;Asolker et al, 2000;Parrota, 2001;Kirthikar & Basu, 2001;Janardhanan et al, 2003).…”

Perfil de flavonoides e avaliação do potencial antioxidante e citotóxico de Bauhinia purpurea (Fabaceae) da região amazônica

“…As substâncias fenólicas, atribuídas como as principais responsáveis por essas atividades, tem sido investigadas por meios cromatográficos e espectrométricos, na busca para estabelecer um perfil cromatográfico dentro da espécie. [16][17][18][19] Na região amazônica, o uso de espécies desse gênero não é diferente, havendo relatos para o tratamento de diabetes nos estados do Acre, Amazonas e Pará. As espécies são encontradas em muitas feiras e comércios a céu aberto, especialmente folhas, para uso como chá.…”

Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)

“…These two actions in turn suppress mediators like prostaglandins responsible for fever [6]. Saponins also have antipyretic activity [35]. The present study therefore suggests that the methanolic bark extracts of T. brownii demonstrated an anti-pyretic activity due to the presence of steroids, terpenoids, flavonoids and saponins that have been revealed to possess anti-pyretic activity.…”