Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)

Mbiri, Jane W; Kasili, Sichangi

doi:10.4172/2472-0992.1000121

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…In this context, a number of medicinal plants such as, T. chebula, T. arjuna, Calyusea abyssinica and Croton macrostachys have been reported to have a similar mode of action with glibenclamide, providing support to our work. 22,30,45,46 Phytochemical screening of methanolic leaf and stem bark extract of T. brownii revealed the presence of tannins, saponins, flavonoids, polyphenols, terpenoids, steroids, phytosterols, and coumarins 17,19 Flavonoids, polyphenols, tannins, saponins, steroids, alkaloids, terpenoids, glycosides, carbohydrates, and polysaccharides have been demonstrated to have antidiabetic activity. 46,47 Thus, the potential antidiabetic activity of the crude extract and solvent fractions of T. brownii could be attributed to the aforementioned bioactive phytochemical implicated for their potential antihyperglycemic activity which might exert their effects individually or in synergy with each other.…”

Section: Discussionmentioning

confidence: 99%

“…11,16 Previous studies indicated that different parts of T. brownii have been shown to exhibit varieties of biological activities including anti-inflammatory, antinociceptive and antipyretic, in vitro antimicrobial and antiplasmodial, central analgesic, and radical scavenging activities. 13,14,[17][18][19][20] Although T. brownii has been traditionally used for management of diabetes and its complication in the Ethiopian folklore medicine, scientific study that supports its traditional claim has not been carried out yet. Therefore, this study aimed to investigate the antidiabetic effect of the crude extract and solvent fractions of T. brownii stem bark.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic Activity of Extracts of Terminalia brownii Fresen. Stem Bark in Mice

Alema¹,

Periasamy²,

Sibhat³

et al. 2020

JEP

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Background: Diabetes mellitus is a chronic metabolic disorder that imposes a huge health and economic burden on societies. Because the currently available medications have many drawbacks, it is important to search for alternative therapies. Medicinal plants used in traditional medicines are ideal candidates. Hence, this study was undertaken to investigate the antidiabetic activity of crude extract and solvent fractions from the stem bark of Terminalia brownii Fresen. (Combretaceae) in mice. Materials and Methods: The in vitro α-amylase inhibition assay was performed using the chromogenic 3, 5-dinitrosalicylic acid (DNSA) method while the antihyperglycemic activity was assessed using three mouse models: streptozotocin-induced diabetic mice, normoglycemic mice, and oral glucose challenged mice. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of 150 mg/kg and animals with fasting blood glucose level (BGL) >200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a standard drug. Fasting BGL and body weight were used to assess the antidiabetic activity. The result was analyzed using GraphPad Prism software version 8 and one-way ANOVA followed by Tukey's post hoc test with p<0.05 considered as statistically significant. Results: The crude extract of T. brownii at all tested dose levels (250, 500 and 750 mg/kg) showed a significant BGL reduction in all the three animal models. Moreover, the ethyl acetate and aqueous fractions (at 500 mg/kg) significantly (p<0.01) reduced the BGL in the streptozotocin induced diabetic model. The crude extract and different solvent fractions also showed a dose-dependent in vitro α-amylase inhibitory activity and improvement of body weight. Conclusion: T. brownii crude extract and its solvent fractions showed a significant antihyperglycemic activity in STZ induced diabetic mice, hypoglycemic activity and improvement of oral glucose tolerance in normal mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Extracts of Terminalia brownii Fresen. Stem Bark in Mice

Alema¹,

Periasamy²,

Sibhat³

et al. 2020

JEP

View full text Add to dashboard Cite

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“…Te plant is used in traditional medicine for managing various ailments, including yellow fever, diabetes, kidney disorders, diarrhea, rheumatism, gastric ulcers, allergy, wounds, back pain, stomachache, fever, malaria, and cough bronchitis, among others [32]. Terminalia brownii has a wide array of biological activities, including anticancer, antimalarial, antipyretic, antinociceptive, preneoplastic lesion prevention, antidiabetic, and antimycobacterial, among others [33][34][35][36][37][38][39]. Despite T. brownii being widely used in folklore medicine and its immense biological activities, its efect on innate immunity remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

Mbiri

Ogila

Kisangau

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Terminalia brownii is widely used in folklore medicine and has diverse biological activities. However, its effect on the immune system is yet to be studied. Therefore, our study evaluated the immunomodulatory effect of T. brownii on nonspecific immunity. Innate immunity is the initial defence phase against pathogens or injuries. Dichloromethane plant extracts were tested on female Swiss albino mice and Wister rats. The effect of the extract on innate immunity was assessed via total and differential leukocyte counts, tumor necrosis factor-alpha, and nitric oxide production by mouse macrophages. The 3-(4, 5-dimethyl thiazolyl-2)-2, 5-diphenyltetrazolium bromide assay was employed for viability testing. Phytochemical profiling was carried out using gas chromatography-mass spectrometry, while toxicity studies were carried out following the Organization for Economic Cooperation and Development guidelines. Our results demonstrated that administration of T. brownii stem bark dichloromethane extract to pyrogallol-immuno compromised mice significantly ( p < 0.05 ) increased total and differential leukocyte counts compared with the control. The extract showed no adverse effect on the viability of Vero cells and macrophages and significantly ( p < 0.05 ) augmented tumor necrosis factor-alpha and nitric oxide production. Hexadecanoic acid, linoleic acid, octadecanoic acid, squalene, campesterol, stigmasterol, and β-sitosterol, all of which stimulate, were identified in the extract. The extract did not cause any death or toxic signs in rats. In conclusion, T. brownii dichloromethane extract has an immunoenhancing effect on innate immune responses and is not toxic. The observed immunoenhancing impact of the extract was attributed to the presence of the identified compounds. The results of this study provide crucial ethnopharmacological leads towards the development of novel immunomodulators for managing immune-related disorders.

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Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)

Cited by 2 publications

References 17 publications

<p>Antidiabetic Activity of Extracts of <em>Terminalia brownii</em> Fresen. Stem Bark in Mice</p>

<p>Antidiabetic Activity of Extracts of <em>Terminalia brownii</em> Fresen. Stem Bark in Mice</p>

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

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