Antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3-carbohydrazide, a new heterocyclic pyrazole derivative

(E)-Substituted-N-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)benzeneamine: synthesis, characterization, antibacterial, and MTT assessment

“…Series of fifteen (E)-Substituted-N-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)benzeneamine derivative (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) was aimed for the synthesis, following the three step procedure (Fig. 1).…”

“…In the second step the Schiff bases undergoes cyclization to yield pyrazole carboxaldehyde (b1-b5) nucleus by using dimethylformamide (DMF) and the desired compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) by the condensation reaction between pyrazole carboxaldehyde (b1-b5) and substituted amines in ethanol and drop of acetic acid under reflux. The prepared derivatives (a1-a5), (b1-b5) and (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were then analyzed for structural confirmation by variety of analytical techniques such as FTIR, NMR, Mass Spectroscopy, Elemental analysis. The FTIR bands around 1590-1602 and 3190-3222 cm −1 due to the presence of C=N and NH functional groups confirmed the formation of compounds (a1-a5), the singlet around 1098-11.18 ppm in 1 H-NMR spectra due to the NH proton and a strong signal around 166.08-166.90 ppm in 13 C-NMR spectra due to C=N carbon further confirmed the formation of compounds (a1-a5).…”

“…[3]. The versatile therapeutic application of the pyrazole derivative have been reported such as antimicrobial [4], Antimalarial [5], anticancer [6], anti-inflammatory [7], antidepressant [8], anticonvulsant [9], selective enzyme inhibitory activities [10], antipyretic [11], analgesic [12], fungicidal [13], fungistatic [14], antihyperglycemic [15], antiviral [16], antitumor [16], etc. On the other hand the derivatives with HC=N functionality have been reported to exhibit many therapeutic effects like antibacterial, antifungal, antimicrobial, anticonvulsant, anti-HIV, and antitumor etc.…”

Crystal structure of N′-(4-(dimethylamino)benzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide, C19H19N5O

“…These derivatives show broad spectrum activity such as anti-in ammatory [1], anti-oxidant [2], antipyretic [3], antimicrobial [4], antiviral [5], anticancer [6], antitumor [7], anticonvulsant [8], analgesic [9], antidepressant [10], insecticides and fungicides [11,12]. For this title structure, the asymmetric unit contains two independent molecules ( gure).…”

Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: The role of nitric oxide

“…The pyrazole ring, bearing atoms of at least two different elements as a member of its ring, is considered to be a privileged structure and an attractive scaffold for drug discovery [10,11]. Pyrazole derivatives represent one of the most active classes of compounds and exhibit a broad spectrum of pharmacological activities, such as antimicrobial [12,13], analgesic [14,15], anti-inflammatory [16e18], antipyretic [15,19], cardiovascular [20] and anticancer [21,22] activities, among others effects.…”