Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Davidson, Elyad; Doursout, Marie–Françoise; Szmuk, Peter; Chelly, Jacques E.

doi:10.1007/bf03019816

Cited by 67 publications

(45 citation statements)

References 20 publications

(19 reference statements)

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“…Nine distinct subtypes of adrenergic receptors have been identified from multiple species: α 1A , α 1B , α 1D , α 2A-2C , and β [1][2][3] (8). Esmolol, a β 1 -adrenergic receptor blocker, reportedly suppressed nociception induced by formalin in rats (9). Additionally, morphine requirements for adequate analgesia in patients who were prescribed esmolol were significantly lower than those in non-prescribed patients, suggesting that β 1 -adrenergic receptors are related to morphine-induced analgesia (10).…”

Section: Introductionmentioning

confidence: 99%

Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

et al. 2013

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Abstract. Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two SNPs, A145G and G1165C, in the human ADRB1 gene in 216 Japanese patients who underwent painful orofacial cosmetic surgery, including bone dissection. The patients who carried the A-allele of the A145G SNP were more sensitive to cold pressorinduced pain than those who did not carry this allele, especially in male patients. The analgesic effect was significantly less in females who carried the G-allele of the G1165C SNP than the females who did not carry the G-allele. The haplotype analysis revealed a significant decrease in 24-h postoperative fentanyl use in female 145A/1165C haplotype carriers. These results suggest that SNPs in the ADRB1 gene are associated with individual differences in pain and analgesic sensitivity, and analyzing these SNPs may promote personalized pain treatment in the future.

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Section: Introductionmentioning

confidence: 99%

Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

et al. 2013

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“…25 There is evidence in the rat that ß-blockers attenuate excitatory neuronal responses in the cingulated cortex 26 or epileptiform responses in the limbic system. 27 The antinociceptive effects of ß-blockers have been noted in rats 28 and in humans with allodynia. 29 Esmolol, pronethalol, and propranolol have also been noted to have local anesthetic properties in animal models.…”

mentioning

confidence: 99%

“…25 Chez le rat, les ß-bloquants diminuent les réponses neuronales excitatrices dans le cortex cingulaire 26 ou les réponses épileptiformes dans le système limbique. 27 Les effets antinociceptifs des ß-bloquants ont été démontrés chez les rats 28 et chez les humains avec l'allodynie. 29 L'esmolol, le pronéthalol et le propranolol ont démontré des propriétés anesthésiques locales chez des modèles animaux.…”

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Are β-blockers anesthestics?

Yang

Fayad

2003

Can J Anesth/J Can Anesth

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“…[20] Hovewer, direct role of esmolol in the modulation of pain pathways during anesthesia has been questioned. Davidson et al [11] showed that esmolol has direct analgesic properties in rats following the injection of formalin. In this study, it was shown that esmolol is involved in the modulation of pain.…”

Section: Discussionmentioning

confidence: 99%

“…It is thought to be involved in pain modulation. [11,12] In this study, our aim was to investigate the effect of esmolol pretreatment on propofol injection pain and to compare its effect with lidocaine.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

E¹,

Titiz²,

Akpek³

et al. 2013

Agri

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SummaryObjectives: Propofol causes considerable pain upon injection, although different methods and propofol formulations have been used to decrease this pain. We aimed to investigate the effect of i.v. esmolol pretreatment on propofol injection pain.Methods: Ninety ASA I-II patients undergoing elective surgery under general anesthesia were randomly assigned into three groups of thirty each. A 20 G cannula was inserted into the dorsum of the nondependent hand. After venous occlusion for one minute, groups E, L and S were pretreated with 5 mg/ml (total 2 ml) esmolol, 40 mg lidocaine and 2 ml saline i.v. respectively. After release of venous occlusion, one fourth of the total propofol dose was administered at a rate of 0.5 ml/sec. During the injection of both pretreatment solution and propofol, patient pain was assessed by using 4 point scale. Heart rate and noninvasive arterial blood pressure values were recorded before induction, just after entubation and five minutes after entubation. Results:Demographic values were similar among groups. Incidence of pain on injection of propofol in the control, esmolol and lidocaine groups was 90%, 33.3%, 50% respectively (p<0.05). Heart rate, systolic arterial pressure, and diastolic arterial pressure values were not different between the groups.Conclusion: Pretreatment with low dose esmolol i.v. seems to be effective in attenuating pain during propofol injection.

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Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Cited by 67 publications

References 20 publications

Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Are β-blockers anesthestics?

Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

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