Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

E, Akgün Salman; Titiz, Lale; Akpek, Elif; Arslan, Gülten

doi:10.5505/agri.2013.29484

Cited by 20 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reason for this difference is unknown. However, there is a possibility that venous occlusion increases the time that FA remains within the vein to inhibit the local inflammatory response [24]. Fujii et al performed a randomized, double-blind, vehicle-controlled, dose-finding trial, in which patients were randomized to receive FA I.V.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: A systematic review and meta-analysis

Bao

2014

Med Sci Monit

View full text Add to dashboard Cite

BackgroundPain on injection is an acknowledged adverse effect (AE) of propofol administration for the induction of general anesthesia. Flurbiprofen axetil has been reported to reduce the pain of injection. However, results of published papers on the efficacy of flurbiprofen axetil in managing pain on injection of propofol are inconsistent.Material/MethodsWe conducted a comprehensive meta-analysis of studies to appraise the efficacy and safety of flurbiprofen axetil for controlling pain induced by propofol injection. The pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) was calculated employing fixed- or random-effects models, depending upon the heterogeneity of the included trials.ResultsCompared with the placebo group, flurbiprofen axetil allows more patients to have no pain (RR 3.51, 95% CI 2.22–5.55, p=0.000), and decreases the cumulative number of patients with mild, moderate, and severe pain on injecting propofol (RR 0.70, 95% CI 0.58–0.86, p=0.000; RR 0.59, 95% CI 0.46–0.75, p=0.000; RR 0.25, 95% CI 0.16–0.38, p=0.000, respectively). In the stratified analysis by the doses, flurbiprofen axetil at a dose of over 50 mg was found to be effective in reducing propofol-induced pain on injection; however, there were no significant differences in relieving pain between treatment and placebo groups with flurbiprofen axetil at a dose of 25 mg. In terms of drug safety, there were no adverse effects (AEs) reported between flurbiprofen axetil-based regimens and placebo regimens.ConclusionsFlurbiprofen axetil, an injectable prodrug of flurbiprofen, can significantly prevent or relieve the pain induced by propofol injection. More studies are required to assess its adverse effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: A systematic review and meta-analysis

Bao

2014

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…The pain from the propofol injection was reduced by 30% due to the 20-mg HnBB pretreatment, similar to the 37% reduction with lidocaine pretreatment [24] and the 33% reduction with low-dose esmolol [25]. However, a combination of lidocaine and nitroglycerine pretreatment has been found to reduce propofol injection pain to 7%, which is better than using either lidocaine or HnBB alone.…”

Section: Discussionmentioning

confidence: 77%

Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study

Sargın¹,

Uluer²,

Aydoğan³

2018

Med Princ Pract

View full text Add to dashboard Cite

Objective: In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection. Subjects and Methods: In this prospective, randomized, placebo-controlled and double-blind trial, 60 patients scheduled to undergo routine outpatient surgery under general anesthesia were randomly allocated to 2 groups, the HnBB (n = 30) and sodium chloride (n = 30) groups. Twenty seconds after the injection of 20 mg HnBB or 0.9 % sodium chloride, a 50-mg dose of propofol was injected in 2–3 s. Ten seconds later, the pain intensity was assessed using a 4-point scale: no pain (0), mild (1), moderate (2), and severe (3) pain. The Student t test was used for the analysis of parametric data and the Pearson χ² test for categorical data. Results: The occurrence of pain in the HnBB group (43.3%) was significantly lower than the control group (73.3%) (p < 0.018). Of the 30 patients in each group, 10 in the control group and 3 in the HnBB group experienced severe pain (p = 0.001). Conclusions: Pretreatment with 20 mg HnBB significantly reduced propofol injection pain compared to placebo.

show abstract

“…Propofolün soğuk uygulanması (4°C), ısıtılarak (37°C) uygulanması, propofol infüzyonunun seyreltilmesi, taşıyıcı infüzyon sıvısının hızının değiştirilmesi (4) , lidokain, nonsteroidal antiinflamatuvar ilaçlar (5,6) , granisetron (1) , metoklopromid (7) , opioidler (8) , hidrokortizon (9) , deksmedetomidin (10) , magnezyum sülfat (11) , efedrin (12) ve kısa etkili beta-bloker (13) ile öntedavi, oral klonidin verilmesi bunlardan bazılarıdır. Bu uygulamaların bir kısmı etkisiz kalırken bir kısmı da ağrıyı tamamen engelleyememiş ancak, ağrı insidansını ve yoğunluğunu azaltmıştır.…”

Section: Discussionunclassified

Effect of the site of intravascular cannula on injection pain of propofol

Şahinkaya¹,

Akpınar²,

Tekgül³

et al. 2016

Terh

View full text Add to dashboard Cite

ÖZAmaç: Propofol hızlı bilinç kaybı ve çabuk derlenme özellikleri nedeniyle genel anestezi indüksiyonunda sıklıkla tercih edilen bir intravenöz sedatif ve hipnotik ajandır. Ancak intravenöz enjeksiyon sırasında yanıcı ağrıya neden olmaktadır. Propofol enjeksiyon ağrısı insidansının %28 ile %90 arasında değiştiği rapor edilmiştir. Bu çalışma ile genel anestezi indüksiyonunda kullanılan propofolün farklı damar yollarından verilmesinin hastada oluşturacağı ağrı ve hasta konforu üzerine etkisinin gözlemlenmesi amaçlanmıştır. Yöntem: Çalışmaya 107 hasta dâhil edildi. Grup 1 (56 hasta)'deki hastalara küçük çaplı venden (el sırtı) ve Grup 2 (51 hasta)'deki hastalara geniş çaplı venden (antekubital) propofol enjekte edildi. Enjeksiyon ağrısı 4 noktalı sözel ağrı derecelendirme skalası ve Wong-Baker yüz skalası ile ölçüldü. Bulgular: Grup 2'de ağrı skorlarında ve ağrı insidansında istatistiksel olarak anlamlı bir azalma görüldü (p<0.001). Sonuç: Sonuç olarak, propofolün büyük çaplı bir vene yerleştirilen intravasküler kanülden uygulanması enjeksiyon ağrısını azaltmada etkilidir. Böylelikle hastalara farmakolojik bir ajan verilmesine gerek kalmamaktadır. Anahtar kelimeler: Antekubital bölge, enjeksiyon ağrısı, propofol ABSTRACTObjective: Propofol is a sedative and hypnothic agent that is mostly used during induction of general anesthesia due to its rapid loss of consciousness and recovery. However it causes pain during intravenous injection. It's reported that incidence of injection site pain of propofol ranges from 28% to 90%. However during intravenous injection it causes burning pain. Methods: 107 patients were included in the study. Propofol was given through a small vein (dorsum of hand) in Group 1 (n=56) patients and through a large vein (antecubital) in Group 2 (n=51) patients. Injection pain was measured using 4 point verbal rating scale and Wong-Baker face scale. Results: It is found that there is a statistically significant decrease in pain scores and incidence in Group 2 (p<0.001). Conclusion: As a result, injection of propofol through an intravascular cannula placed in a large vein is effective for reducing injection site pain. So that, patients have no need for another medication.

show abstract

Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.

Cited by 20 publications

References 25 publications

Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: A systematic review and meta-analysis

Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: A systematic review and meta-analysis

Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study

Effect of the site of intravascular cannula on injection pain of propofol

Contact Info

Product

Resources

About