Association Between Genetic Polymorphisms of the ^|^beta;1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Abstract

Abstract. Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two SNPs, A145G and G1165C, in the human ADRB1 gene in 216 Japanese patients who underwent painful orofacial cosmetic surgery, including bone dissection. The patients who carried the A-allele of the A145G SNP were more sensitive to cold pressorinduced pain than those who did not carry this allele, especially in male patients. The analgesic effect was significantly less in females who carried the G-allele of the G1165C SNP than the females who did not carry the G-allele. The haplotype analysis revealed a significant decrease in 24-h postoperative fentanyl use in female 145A/1165C haplotype carriers. These results suggest that SNPs in the ADRB1 gene are associated with individual differences in pain and analgesic sensitivity, and analyzing these SNPs may promote personalized pain treatment in the future.

Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients

“…PCR amplification of G1165C was performed using primers mentioned in Table 1. Genotyping of G1165C was done as described previously by Moriyama et al (32). An Eppendorf gradient Master cycler (Hamburg, Germany) PCR machine was used as the thermal cycler.…”

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

“…rs1801252 and rs1801253 are embedded single nucleotide polymorphisms (SNPs) in ADRB1 gene with clinical significance in hypertension, stroke, heart disease, pain and analgesic sensitivity. In Chinese population, different response according to variety of rs1801252 and rs1801253 SNPs to pain is reported, also Japanese population response to Fentanyl is affected by these SNPs [69][70][71].…”

Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population

“…In the present study, except for OPRM1, ABCB1, UGT2B7, and P2RX7, we selected other 14 genes known to be involved in systems related to pain perception and modulation based on evidence in the literature. The selected genes have been related to the ion channels (SCN9A, SCN10A, SCN11A, KCNJ6, TRPV1, and CACN A1E) [15][16][17][18][19][20], dopaminergic system (COMT, DRD2) [21,22], purinergic receptor (P2RY12) [23], adrenergic receptor (ADRB1) [24], estrogen receptor (ESR1) [25], serine/ threonine kinase (TAOK3) [26], growth factors (TGFB1) [27], and transcription factor (CREB1) [28]. The aim of the present study was to evaluate the association of common SNPs among aforementioned genes with the inadequate analgesia after single-port VATS.…”