Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models

Xue, Na; Wu, Xinyu; Wu, Li; Li, Lü; Fang, Wanliang

doi:10.1016/j.lfs.2018.11.013

Cited by 42 publications

(28 citation statements)

References 28 publications

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“…Shikoniin ( Pharmacological activities of naringenin (2), as therapeutic agent to treat different diseases, such as cancer, diabetes, cardiovascular diseases and neurological disorders, oxidative stress and inflammation have been extensively reported [37,38]. Additionally, antibacterial activity against Salmonella thypi, Staphylococcus aureus, and Escherichia coli ATCC as well as their antinociceptive and anti-inflammatory effect in mice model, have been also reported [39][40][41][42]. Furthermore, the free Additionally, afzelechin (4), epiafzelechin (6), and some catechol derivatives have been extensively reported as antioxidant compounds.…”

Section: Naringenin (2)mentioning

confidence: 99%

UHPLC-HESI-OT-MS-MS Biomolecules Profiling, Antioxidant and Antibacterial Activity of the “Orange-Yellow Resin” from Zuccagnia punctata Cav.

et al. 2020

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This research was designed to investigate the metabolite profiling, phenolics, and flavonoids content as well as the potential antioxidant and antibacterial, properties of orange-yellow resin from Zuccagnia punctata Cav (ZpRe). Metabolite profiling was obtained by a ultrahigh resolution liquid chromatography orbitrap MS analysis (UHPLC-ESI-OT-MS-MS). The antioxidant properties were screened by four methods: 2,2-diphenyl-1-picrylhydrazyl assay (DPPH), trolox equivalent antioxidant activity assay (TEAC), ferric-reducing antioxidant power assay (FRAP), and lipid peroxidation in erythrocytes (LP)). The antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) rules. The resin displayed a strong DPPH scavenging activity (IC 50 = 25.72 µg/mL) and showed a percentage of inhibition of LP close to that of the reference compound catechin (70% at 100 µg ZpRe/mL), while a moderated effect was observed in the FRAP and TEAC assays. The resin showed a content of phenolic and flavonoid compounds of 391 mg GAE/g and 313 mg EQ/g respectively. Fifty phenolics compounds were identified by ultrahigh resolution liquid chromatography orbitrap MS analysis (UHPLC-PDA-OT-MS) analysis. Thirty-one compounds are reported for the first time, updating the knowledge on the chemical profile of this species. The importance of the biomolecules identified support traditional use of this endemic plant. Furthermore, additional pharmacological data is presented that increase the potential interest of this plant for industrial sustainable applications.

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Section: Naringenin (2)mentioning

confidence: 99%

UHPLC-HESI-OT-MS-MS Biomolecules Profiling, Antioxidant and Antibacterial Activity of the “Orange-Yellow Resin” from Zuccagnia punctata Cav.

et al. 2020

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“…HBl, honeyberry leaf extract; HBB, honeyberry bark extract; nrf2, nuclear factor erythroid 2-related factor 2; nac, n-acetyl-l-cysteine; TBP, TaTa-box-binding protein; dMSo, dimethylsulfoxide. excessive inflammatory responses should be controlled to prevent the development of chronic inflammation-associated diseases (1,2). The development of new anti-inflammatory agents is desirable due to the side effects and treatment failures associated with currently available anti-inflammatory drugs (35).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation, which is one of the physical barriers of innate immunity, is the protective response by which the body eliminates harmful stimuli, such as damaged cells, pathogens and irritants (1). However, the prolonged inflammatory response of immune cells to noxious stimuli leads to chronic inflammation, which causes various diseases, including rheumatoid arthritis, type 2 diabetes, cancer, cirrhosis, alzheimer's disease and neurological diseases (2). Macrophages, which play a pivotal role in the innate immune system, release various inflammatory cytokines and mediators to protect the body from external harmful factors (3).…”

Section: Introductionmentioning

confidence: 99%

“…currently used anti-inf lammatory drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), may cause serious side effects. Therefore, numerous researchers have focused on the development of anti-inflammatory drugs from plant sources that are considered to be safe, effective, biocompatible and cost-effective alternatives (2). Berries are fruits rich in nutritive compounds, such as minerals, vitamins and dietary fiber.…”

Section: Introductionmentioning

confidence: 99%

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Anti‑inflammatory effects of leaf and branch extracts of honeyberry (Lonicera caerulea) on lipopolysaccharide‑stimulated RAW264.7 cells through ATF3 and Nrf2/HO‑1 activation

Son

Geum

et al. 2020

Mol Med Rep

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Honeyberry (Lonicera caerulea) has long been used as a traditional medicine in china, Japan and northern russia. Functional studies of honeyberry have mainly focused on the fruits, which have been reported to exert various pharmacological activities, including anti-inflammatory activity, with limited or no studies on the other parts of the plant, such as the leaves and branches. In the present study, the anti-inflammatory effects of extracts of the leaves (HBl), branches (HBB) and fruit (HBF) of honeyberry plant were evaluated in lipopolysaccharide (lPS)-stimulated raW264.7 cells. HBL and HBB significantly inhibited the production of proinflammatory mediators in LPS-stimulated RAW264.7 cells, and the inhibitory effects of HBl and HBB were stronger than those of HBF. HBl and HBB blocked the nuclear accumulation of p65 independently of iκB-α. HBl did not inhibit the phosphorylation of erK1/2 or p38; however, HBB effectively inhibited the phosphorylation of p38 but not erK1/2. HBl and HBB increased the expression of heme oxygenase-1 (Ho-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (nrf2) through the activation of the reactive oxygen species (roS)/p38 pathway; the reduction in inducible nitric oxide synthase (inoS) and interleukin-1β (il-1β) expression by HBl and HBB was inhibited by Ho-1 knockdown. in addition, HBl and HBB increased the expression of activating transcription factor-3 (aTF3), and the reduction in inoS and il-1β expression by HBl and HBB was inhibited by aTF3 knockdown. collectively, HBl and HBB inhibited lPS-induced nuclear factor-κB activation by blocking the nuclear accumulation of p65, increasing Ho-1 expression through activation of the roS/p38/nrf2 pathway, and increasing aTF3 expression. Furthermore, HBB inhibited LPS-induced p38 phosphorylation. These findings suggest that HBl and HBB may have great potential as natural products for the development of anti-inflammatory drugs.

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“…Hence, the major flavonoid content could be responsible for the antipyretic effect as well as the analgesic and anti-inflammatory activities of nectarine kernels. Recently, naringenin was found to be a potent antinociceptive and anti-inflammatory drug [36], and apigenin showed promising analgesic and anti-inflammatory properties [37]. On the other hand, the cyanogenic glycoside amygdalin was reported to exert antinociceptive and anti-inflammatory actions alleviating inflammatory pain [38], thus leading to hypothesize a role in the biological activity of nectarine kernel extract.…”

Section: Groupsmentioning

confidence: 99%

Evaluation of Anti-inflammatory, Antinociceptive, and Antipyretic Activities of Prunus persica var. nucipersica (Nectarine) Kernel

et al. 2019

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Nectarine (Prunus persica var. nucipersica) is a worldwide appreciated edible subspecies, with a high nutritional value and benefits on human health due to its phenolic content. Despite the large consumption of the fruit, the potential use of its kernel is poorly studied. Herein, the potential pharmacological activities and the phenolic constituents of an alcoholic extract of kernel nectarine fruits were investigated. Administering nectarine kernel extract (50 and 100 mg/kg, respectively) in rats reduced paw edema after carrageenan injection by 11 and 47% in 1 h, 24 and 33% in 2 h, and 23 and 32% in 4 h, when compared to the controls. At the higher dose (100 mg/kg), nectarine kernel extract increased the reaction time in the hot-plate model and produced a significant decrease in the rectal temperature of the pyretic rats, while both doses produced 52 and 59% of writhing inhibition compared to the control group. Total polyphenolic (55.91 ± 5.78 mg/g) and flavonoid (29.89 ± 0.55 mg/g) content indicated that the extract is a promising source of these constituents. HPLC-ESI-MS/MS analysis demonstrated the presence of flavonoids, such as naringenin and apigenin glycosides. The cyanogenic glycosides amigdalin and prunasin were also detected. These results highlight the anti-inflammatory, analgesic, and antipyretic activities of nectarine kernel alcoholic extract, together with significant phenolic content, promoting its exploitation as a source of bioactive molecules.

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Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models

Cited by 42 publications

References 28 publications

UHPLC-HESI-OT-MS-MS Biomolecules Profiling, Antioxidant and Antibacterial Activity of the “Orange-Yellow Resin” from Zuccagnia punctata Cav.

UHPLC-HESI-OT-MS-MS Biomolecules Profiling, Antioxidant and Antibacterial Activity of the “Orange-Yellow Resin” from Zuccagnia punctata Cav.

Anti‑inflammatory effects of leaf and branch extracts of honeyberry (Lonicera caerulea) on lipopolysaccharide‑stimulated RAW264.7 cells through ATF3 and Nrf2/HO‑1 activation

Evaluation of Anti-inflammatory, Antinociceptive, and Antipyretic Activities of Prunus persica var. nucipersica (Nectarine) Kernel

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