Antinociceptive and anti-inflammatory activities of Philodendron bipinnatifidum Schott ex Endl (Araceae)

Scapinello, Jaqueline; Müller, Liz Girardi; Schindler, Monica Santin Zanatta; Anzollin, Gabriela Sabrina; Siebel, Anna Maria; Boligon, Alexandra Augusti; Niero, Rivaldo; Saraiva, Thalia Emmanoella Sebulsqui; Maus, Nathália Pulz; Betti, Andresa Heemann; Oliveira, J. Vladimir; Magro, Jacir Dal; Oliveira, Débora de

doi:10.1016/j.jep.2019.02.037

Cited by 23 publications

(25 citation statements)

References 48 publications

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“…Taken together, these data may constitute a scientific basis for the use of these species in Cacoal Community, as pain represents one of the cardinal signs of inflammation and antiinflammatory drugs are provided with analgesic action (SCAPINELLO et al, 2019).…”

Section: Discussionmentioning

confidence: 95%

“…Another strategy employed by the Cacoal community natives to treat pain is the leaves of Monstera spruceana, prepared by infusion. Although no studies showing the pharmacological effect of this species have been found, it has been shown that Philodendron bipinnatifidum of the Araceae family, which belongs to M. spruceana, has analgesic and anti-inflammatory activities related to the presence of flavonoids and phytosterols (SCAPINELLO et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Meneguelli

Camargo²,

Buccini

et al. 2020

Inter

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Plants have been widely used to treat many diseases, especially by traditional communities as Indians, that can be considered as an important source of empirical knowledge about the medicinal potential of the Brazilian biodiversity. This study aimed to investigate the use of medicinal plants by a particular Amazon-Indian community named Ikólóéhj (Gavião). The data was obtained based on a semi-structured interview and long-term visits along the indigenous area to harvest the botanical material to subsequent identification and storage in herbarium. In the present work, we identify 23 plant species and three morphospecies, distributed into Ferns / Lycophytes and Angiosperms. In addition, we show that leaves (78%), bark (13%) and roots (9%) were used via maceration (49%), topical use (26%), infusion and bath (13%), and decoction (9%). These plants were used to treat pain, diarrhea, malnutrition, parasites infection, wounds, and snakebites. We also observe that the knowledge about medicinal plants is shared to the older members of the community and this information is transmitted orally to the next generations. Thus, the present study contributes to the regrowth and preservation of knowledge about the use of medicinal plants providing important subsidies for understanding of therapeutic properties of Amazonian plants.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Meneguelli

Camargo²,

Buccini

et al. 2020

Inter

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show abstract

“…Furthermore, in vivo carrageenan-induced paw oedema model is the most common animal protocol frequently used to determine the anti-inflammatory and anti-oedema properties of natural remedies. [26][27][28] This model is principally based on the release of inflammatory mediators. 29 The ethanolic leaf extract of H. schulli exhibited significant (P<0.05) anti-inflammatory activity against carrageenan-induced hind paw oedema in mice at two-, three-, and four-hours post-carrageenan injection.…”

Section: Discussionmentioning

confidence: 99%

<p>Anti-Nociceptive and Anti-Inflammatory Activity of <em>Hygrophila schulli</em> Leaves</p>

Tekulu¹,

Desta²,

Hiben³

et al. 2020

JIR

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The management of pain and inflammation with non-steroidal anti-inflammatory drugs and opioid analgesics are currently encountering severe adverse reactions. To overcome these problems, herbal remedies may offer new alternative medicines. Hygrophila schulli is a medicinal plant traditionally used for the treatment of pain and inflammationrelated disorders; yet, these claims are not scientifically validated. Hence, this study was aimed to validate the traditional use of Hygrophila schulli leaves as anti-inflammatory and analgesic remedy. Methods: In vitro anti-hyaluronidase assay and in vivo carrageenan-induced hind paw oedema model were used to evaluate the anti-inflammatory property of ethanolic leaf extract of Hygrophila schulli. Tail immersion and acetic acid-induced writhing tests were performed to determine the central and peripheral analgesic activity of the leaf extract, respectively. Results: The ethanolic leaf extract exhibited significant anti-hyaluronidase activity (P<0.001) and significant inhibition of carrageenan-induced paw oedema (P<0.05) compared to untreated controls. Similarly, the extract significantly prolonged the reaction time of mice (P<0.05) for the hot-water stimuli. Furthermore, an oral dose of the extract showed significant inhibition (P<0.01) of acetic acid-induced abdominal contractions of mice. Besides, the ethanolic leaf extract did not cause any obvious sign of acute toxicity at a single oral dose of 2 g/kg. Conclusion: The findings of this study may partially support the acclaimed traditional use of Hygrophila schulli leaves for the treatment of pain and inflammatory conditions.

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“…One possible reason for the popularity of exploratory behavior measures is that measures of locomotor activity are used in (almost) any behavioral phenotyping laboratory, and have been used classically (and remain in frequent use) in pain-free animals to study the influence of analgesic drugs on locomotor activity (e.g. Sánchez-Fernández et al, 2013;Mansouri et al, 2014;Birmann et al, 2018;Scapinello et al, 2019). Therefore, actimeters and open fields are available to many pain researchers who can readily use them to test whether their animal pain models reveal deficits in exploratory activity as a complementary outcome.…”

Section: Pain Interference In Exploratory Locomotion In a Novel Envirmentioning

confidence: 99%

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

González‐Cano

Montilla-García

Ruiz-Cantero

et al. 2020

Neuroscience & Biobehavioral Reviews

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Antinociceptive and anti-inflammatory activities of Philodendron bipinnatifidum Schott ex Endl (Araceae)

Cited by 23 publications

References 48 publications

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

<p>Anti-Nociceptive and Anti-Inflammatory Activity of <em>Hygrophila schulli</em> Leaves</p>

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

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