The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

González‐Cano, Rafael; Montilla-García, Ángeles; Ruiz-Cantero, M. Carmen; Bravo-Caparrós, Inmaculada; Tejada, Miguel; Nieto, Francisco R.; Cobos, Enrique J.

doi:10.1016/j.neubiorev.2020.03.004

Cited by 39 publications

(30 citation statements)

References 312 publications

(455 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the conventional rodent models of nociception, the formalin-induced paw-licking test and the acetic-acid-induced writhing test are the most widely used for assessing chemical-induced acute pain ( Le Bars et al, 2001 ; González-Cano et al, 2020 ). Therefore, we also assessed pain responses caused by citric acid in these models and examined whether these responses are also ASIC1 dependent.…”

Section: Resultsmentioning

confidence: 99%

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1

Yang

Lai

2021

J. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1

Yang

Lai

2021

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The hot plate is one of the oldest and frequently used animal models to quantify “pain-like” behaviors in rodents [ 53 ]. Based on the species and strain of rodents used in clinical studies, nearly 12 different behaviors, including grooming, freezing, sniffing, licking, stamping of the legs, leaning, and jumping, have been measured in the hot plate assay [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

View full text Add to dashboard Cite

Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

show abstract

“…The injection of formalin into the hind paw is widely used to evaluate the effects of analgesic compounds in laboratory animals. Intraplantar formalin excites sensory neurons by activating excitatory TRPA1 channels and this activity underlies the physiological and behavioral responses associated with this model of pain hypersensitivity, such as licking and biting responses [21,58]. The intraplantar injection of 0.5% formalin produced a biphasic behavioral reaction, with an initial phase lasting 5 min and a quiescent period, followed by a second less intense phase lasting from 10 to 25 min.…”

Section: Inflammatory and Neuropathic Pain Alters Trpa1 Channel Assocmentioning

confidence: 99%

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

Cortés-Montero

Rodríguez-Muñoz

Ruiz-Cantero

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Transient receptor potential ankyrin member 1 (TRPA1) belongs to the family of thermo TRP cation channels that detect harmful temperatures, acids and numerous chemical pollutants. TRPA1 is expressed in nervous tissue, where it participates in the genesis of nociceptive signals in response to noxious stimuli and mediates mechanical hyperalgesia and allodynia associated with different neuropathies. The glutamate N-methyl-d-aspartate receptor (NMDAR), which plays a relevant role in allodynia to mechanical stimuli, is connected via histidine triad nucleotide-binding protein 1 (HINT1) and type 1 sigma receptor (σ1R) to mu-opioid receptors (MORs), which mediate the most potent pain relief. Notably, neuropathic pain causes a reduction in MOR antinociceptive efficacy, which can be reversed by blocking spinal NMDARs and TRPA1 channels. Thus, we studied whether TRPA1 channels form complexes with MORs and NMDARs that may be implicated in the aforementioned nociceptive signals. Our data suggest that TRPA1 channels functionally associate with MORs, delta opioid receptors and NMDARs in the dorsal root ganglia, the spinal cord and brain areas. These associations were altered in response to pharmacological interventions and the induction of inflammatory and also neuropathic pain. The MOR-TRPA1 and NMDAR-TRPA1 associations do not require HINT1 or σ1R but appear to be mediated by calcium-activated calmodulin. Thus, TRPA1 channels may associate with NMDARs to promote ascending acute and chronic pain signals and to control MOR antinociception.

show abstract

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

Cited by 39 publications

References 312 publications

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

Contact Info

Product

Resources

About