Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)

Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea (Aubl.) Jacks in vivo

“…These results support the hypothesis that MEOC may act by inhibiting prostaglandin synthesis because of the nociceptive mechanism of abdominal writhing induced by acetic acid metabolites via cyclooxygenase and prostaglandin biosynthesis [22,32]. However, an important disadvantage of the acetic acid-induced abdominal writhing test model is that other classes of drugs, including adrenergic receptor antagonists, antihistamines, central nervous system stimulants, monoamine oxidase inhibitors, serotonin antagonists, muscle relaxants, and neuroleptics, can also inhibit abdominal writhing, favoring possible false-positive result [22,28,32]. Due to the lack of specificity, positive results in the abdominal writhing test should be recognized in the context of results obtained in other experimental models.…”

“…Intraplantar injection of formalin has been reported to produce a distinct biphasic nociceptive response [12,21], termed first and second phases [20]. The first phase, commonly denominated early or neurogenic phase (from 0 to 5 min after injection formalin) results from a direct stimulation of nociceptors (predominantly C-fibres) [22,23,27,28,31,32,34]. Substance P, glutamate and bradykinin are thought to participate in this phase, which is believed to be non-inflammatory pain [28].…”

Antinociceptive activities of crude methanolic extract and phases, n-butanolic, chloroformic and ethyl acetate from Caulerpa racemosa (Caulerpaceae)

“…The extract and phases of C. racemosa tested in this study showed significant effect on this viscero-somatic model (tonic pain) reflected in a significant reduction of the acetic acidinduced abdominal writhing. The acetic acid-induced abdominal writhing involves the production and release of arachidonic acid metabolites via cycloxygenase (COX) and prostaglandin biosynthesis (Dongmo et al, 2005). However, this test is a nonspecific model (e.g.…”

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

“…Traditionally used large numberbioactive flavonoids, alkaloids, phenolics, saponins, polysaccharides, tannins and terpenoids (Seigler, 2003). The published reports of various biological activities of Acacia species include hypoglycemic, anti-inflammatory, antitumor (Lam and Ng, 2010), antifungal (Lopes et al, 2009), antiplatelet aggregation, spasmogenic and vasoconstrictor, antihypertensive, anti-hepatitis C virus (Lee et al, 2011) antioxidant potential , wound healing (Tung et al, 2008), antinociceptive activity (Dongmo et al, 2005), chemopreventive and antimutagenic , anthelmintic activity (Bachaya et al, 2009). Several bioactive agents have been identified from the various species of acacia which includes androstene steroid, gallic acid, ellagic acid, isoquercitin, kaempferol, naringenin, rutin, lupane, niloticane, umbelliferone and catechin (Mutai et al, 2004;Eldeen et al, 2005;Chaubal et al, 2006;Singh et al, 2010).…”

“…So far several biologically active compounds include umbelliferone, gallic acid, niloticane, catechin, kaempferol, rutin, apigenin and two steroids include androstene and β-sitoterol were isolated from different parts of A.nilotica (Brahma et al, 2009). Numerous studies in A.nilotica showed interesting biological activities (Dongmo et al, 2005;Meena et al, 2006;Tung et al, 2008;Bachaya et al, 2009;Lopes et al, 2009;Lam and Ng, (2010); Singh et al, 2010;Lee et al, 2011) however, no antitumor activity against DAL induced solid and ascitic tumor has been reported. Therefore based on the ethno medical claims, the present study was planned to explore the possible in vivo antitumor activity of aerial parts of A.nilotica against DAL induced solid and ascitic tumor in BALB/c mice.…”