Antinociceptive and anti-arthritic effects of kramecyne

Alonso-Castro, Ángel Josabad; Zavala-Sánchez, Miguel Ángel; Pérez‐Ramos, Julia; Sánchez-Mendoza, Ernesto; Pérez-Gutiérrez, Salúd

doi:10.1016/j.lfs.2014.11.015

Cited by 8 publications

(10 citation statements)

References 30 publications

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“…In previous studies, the in vivo antiinflammatory effects of KACY were evaluated in localized models of inflammation [P erez-Guti errez et al, 2012;Alonso-Castro et al, 2015]. In this study, the effects of KACY on LPS-induced systemic chronic inflammation and its gastroprotective activities were investigated with KACY dosed at 50 mg/kg po,.…”

Section: Discussionmentioning

confidence: 99%

“…[P erez-Guti errez et al, 2012;Alonso-Castro et al, 2015], and in vitro at 31.25-250 mg/ml [S anchez-Miranda et al, 2013]. It also has antinociceptive activities [Alonso-Castro et al, 2015]. In the present study, we evaluated the anti-inflammatory effects of KACY in a mouse model of systemic chronic inflammation induced with intraperitoneal injection of LPS twice per week for 60 days.…”

Section: Introductionmentioning

confidence: 97%

“…This compound had an LD 50 > mg/kg p.o., exerted in vivo anti‐inflammatory effects at 50 and 100 mg/kg .pp. [Pérez‐Gutiérrez et al, ; Alonso‐Castro et al, ], and in vitro at 31.25–250 µg/ml [Sánchez‐Miranda et al, ]. It also has antinociceptive activities [Alonso‐Castro et al, ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Kramecyne on LPS Induced Chronic Inflammation and Gastric Ulcers

Alonso-Castro

Pérez‐Ramos

Sánchez-Mendoza

et al. 2015

Drug Development Research

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Preclinical Research Krameria cytisoides is used for the treatment of inflammation, stomach pain, and gastric ulcers. The active ingredient from this plant is a peroxide, kramecyne (KACY) which has anti-inflammatory effects. The aim of the present study was to evaluate the anti-inflammatory activities of KACY in lipopolysaccharide (LPS)-induced systemic chronic inflammation in mice for 60 days, using dexamethasone (DEX) as the positive control, vehicle (the LPS group) as the negative control and the control group (mice without inflammation). KACY did not affect survival, body weight or relative organ weight in mice but it: decreased nitric oxide (NO) production by 68%; prostaglandin E2 (PGE2 ) by 67%; increased release of anti-inflammatory cytokine IL-10 (2.0-fold), and reduced production of the proinflammatory cytokines, IL-6 (2.0-fold), IL-1β (2.4-fold), and TNF-α (2.0-fold). Furthermore, the gastroprotective effects of KACY in mice were evaluated in an ethanol-induced gastric ulcer model. The results showed that KACY at 50 and 100 mg/kg exerted gastroprotective effects with similar activity to 50 mg/kg ranitidine. In gastric tissues, KACY decreased the level of malondialdehyde (MDA) but increased the catalase (CAT) activity. KACY have potential for the treatment of chronic inflammatory diseases due its similar activity to that of DEX. It also has gastroprotective effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Effects of Kramecyne on LPS Induced Chronic Inflammation and Gastric Ulcers

Alonso-Castro

Pérez‐Ramos

Sánchez-Mendoza

et al. 2015

Drug Development Research

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“…Hot plate test was performed according to the method of Turner [ 17 ]. The method was used to evaluate the central mechanism of analgesic activity [ 18 ]. At first, mice were screened for this test by inserting them on a hot plate individually that was kept at (55 ± 1)°C.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks

Moushome

Akter

Aziz

2016

BioMed Research International

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Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract of Microcos paniculata barks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities. Methods. Phytochemical constituents and antinociceptive and antidiarrheal activities were determined and evaluated by different tests such as Molisch's, Fehling's, Mayer's, Wagner's, Dragendorff's, frothing, FeCl3, alkali, Pew's, and Salkowski's test, general test of glycosides, Baljet and NH4OH test, formalin-induced paw licking, acetic acid-induced writhing, tail immersion, and hot plate tests, and castor oil and MgSO4 induced diarrheal tests. Results. These extracts revealed the presence of saponins, flavonoids, and triterpenoids and significantly (⁎ P < 0.05, versus control) reduced paw licking and abdominal writhing of mice. At 30 min after their administration, PBMPB revealed significant increase in latency (⁎ P < 0.05, versus control) in tail immersion test. In hot plate test, HMPB and PBMPB 200 mg/kg showed significant increase in response latency (⁎ P < 0.05, versus control) at 30 min after their administration. Moreover, both extracts significantly (⁎ P < 0.05, versus control) inhibited percentage of diarrhea in antidiarrheal models. Conclusion. Study results indicate that M. paniculata may provide a source of plant compounds with antinociceptive and antidiarrheal activities.

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“…Since topical drug formulations of NSAIDs are amongst the most frequently administered over-the-counter (OTC) drugs, the introduction of a new preparation of this group requires any comparison of its anti-inflammatory and analgesic efficacy to the corresponding standard [67]. 2.5% formalin injection to the mice paw shows a biphasic response and exhibits behavioral pain by flinching and licking of the affected paw [68].…”

Section: Effects Of Aceos On Formalin-induced Pain Andmentioning

confidence: 99%

Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action

Chandrakanthan

Handunnetti

Premakumara

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Alpinia calcarata Rosc. (ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and α-terpineol using mouse ear edema model. ACEOs were analyzed by GC-MS. The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators—nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages. Topical anti-inflammatory and antinociceptive activity was studied by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation and formalin-induced pain model in mice, respectively. Rhizome oil has 1,8-cineole (31.08%), α-terpineol (10.31%), and fenchyl acetate (10.73%) as major compounds whereas the ACEO from leaves has 1,8-cineole (38.45%), a-terpineol (11.62%), and camphor (10%). ACEOs reduced the production of inflammatory mediators in vitro in a concentration-dependent manner. Further, ACEO and its major compounds reduced ear thickness, weight, myeloperoxidase, and cytokines significantly (p<0.01) in mouse ear. Dose-dependent reduction in flinching and licking in both the phases of pain sensation concludes the topical analgesic effect. Our findings suggest the potency of topical use of ACEOs for inflammatory disease conditions.

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Antinociceptive and anti-arthritic effects of kramecyne

Cited by 8 publications

References 30 publications

Effects of Kramecyne on LPS Induced Chronic Inflammation and Gastric Ulcers

Effects of Kramecyne on LPS Induced Chronic Inflammation and Gastric Ulcers

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks

Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action

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