Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

“…7 The antinociceptive activity of this species in an arthritic pain model involving 5-HT 1A receptors was demonstrated in other study. 15 Another study reports that the anxiolytic-like effects of a standardized fraction from inflorescences of T. americana is mediated by serotonergic receptors; the standardization was supported in the flavonoids contained: tiliroside, rutin, quercetin, a quercetin glucoside and kaempferol.…”

Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

“…The peak at 16.2min is probably procyanidin dimer B2 (dimer of flavonol catechin) (compound 1, Table Tilia sp. (Tiliaceae) have been used around the world due to its anxiolytic and sedative activity, and quercetin and kaempferol flavonoids have been shown to be responsible for its sedative effect (Aguirre-Hernandez et al, 2010;Viola et al, 1994;Martinez et al, 2009). Tilia extracts acted as an agonist of the peripheral benzodiazepine receptor, suggesting the presence of flavonoids capable of binding to the peripheral type of benzodiazepine receptor binding sites (Aguirre-Hernandez et al, 2010;Viola et al, 1994).…”

“…mexicana aqueous extract produced an antinociceptive effect in models like formalin and arthritic pain, reinforcing its use for treating this type of affection in folk medicine, in which an anxiolytic compound is probably involved. The chromatographic analyses of aqueous extracts indicate the presence of glycosides from quercetin such as kaempferitrin, isoquercitrin, astragalin and tiliroside as flavonoids responsible for the antinociceptive activity (Loscalzo et al, 2009;Martinez et al, 2009). Kaempferitrin, isoquercitrin, astragalin and tiliroside have been reported as the major compounds in polar extracts of various Tilia species such as: Tilia cordata, Tilia rubra, Tilia argentea, and Tilia platyphyllos (Loscalzo et al, 2009;Martinez et al, 2009).…”

“…The chromatographic analyses of aqueous extracts indicate the presence of glycosides from quercetin such as kaempferitrin, isoquercitrin, astragalin and tiliroside as flavonoids responsible for the antinociceptive activity (Loscalzo et al, 2009;Martinez et al, 2009). Kaempferitrin, isoquercitrin, astragalin and tiliroside have been reported as the major compounds in polar extracts of various Tilia species such as: Tilia cordata, Tilia rubra, Tilia argentea, and Tilia platyphyllos (Loscalzo et al, 2009;Martinez et al, 2009). Phytochemical analyses evidenced that flavonoids comprise the principal group of compounds present in the anxiolytic extract of T. Americana (Herrera-Ruiz et al, 2008) and the anxiolytic activity of T. americana var.…”

Antinociceptive activity of Hypericum grandifolium Choisy in mice

“…Since previous studies have shown that the flavonoids quercetin, quercitrin and hyperoside possess antinociceptive effects when tested individually [33][34][35], it is possible that the flavonoids present in the methanol extracts and butanol fraction of this species may be responsible, at least in part, for the antinociceptive effects reported here. On the other hand, since the benzophenone derivatives were detected as major compounds in the chloroform fraction and their subfractions, it can be hypothesized that these compounds may be also associated with the effects found in the present study.…”