Antimycotic potential of a diterpenoid taxoquinone against &lt;i&gt;Candida&lt;/i&gt; species isolated from &lt;i&gt;Metasequoia glyptostroboides&lt;/i&gt;

Bajpai, Vivek K.; Kang, Sun Chul

doi:10.3329/bjp.v9i2.17555

Cited by 7 publications

(6 citation statements)

References 17 publications

(14 reference statements)

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“…These include three antifungal diterpenoids reported by Asahi and Sakan (1984) (Table 1, compounds 305–307) and the diterpenoid taxoquinone (Bajpai and Kang 2014). The latter compound exhibited significant antifungal activity against pathogenic isolates of several Candida species.…”

Section: Antifungal and Antidermatophytic Effectsmentioning

confidence: 99%

Growing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng—a molecular reservoir from the ancient world with potential in modern medicine

et al. 2015

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After the sensational rediscovery of living exemplars of the Cretaceous relict Metasequoia glyptostroboides—a tree previously known exclusively from fossils from various locations in the northern hemisphere, there has been an increasing interest in discovery of novel natural products from this unique plant source. This article includes the first complete compilation of natural products reported from M. glyptostroboides during the entire period in which the tree has been investigated (1954–2014) with main focus on the compounds specific to this plant source. Studies on the biological activity of pure compounds and extracts derived from M. glyptostroboides are reviewed for the first time. The unique potential of M. glyptostroboides as a source of bioactive constituents is founded on the fact that the tree seems to have survived unchanged since the Cretaceous era. Since then, its molecular defense system has resisted the attacks of millions of generations of pathogens. In line with this, some recent landmarks in Metasequoia paleobotany are covered. Initial spectral analysis of recently discovered intact 53 million year old wood and amber of Metasequoia strongly indicate that the tree has remained unchanged for millions of years at the molecular level.

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Section: Antifungal and Antidermatophytic Effectsmentioning

confidence: 99%

Growing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng—a molecular reservoir from the ancient world with potential in modern medicine

et al. 2015

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“…Extracts from M. glyptostroboides have been shown to exhibit antioxidant activity [94,95], antibacterial effects [96][97][98], antifungal activity [99], potential antidermatophytic activity [94,99] and additionally a mixture of flavonoids referred to as total flavonoids from M. glyptostroboides has been reported to exhibit protective effects on cerebral-ischemia-reperfusion injury in rats [100]. Pure natural products identified from M. glyptostroboides have been reported to exhibit antioxidant activity [101,102], inhibition of arachidonic acid metabolism [102], antibiotic activity towards bacteria [103][104][105][106], antifungal activity [107], antiviral activity [108] and anticancer activity [109]. Additionally Jung et al have patented an anticancer drug based on 2, 3-dihydrohinokiflavone [110].…”

Section: A Novel Dihydrostilebenoid Glucoside and Seven Other Naturalmentioning

confidence: 99%

Novel aminoalkaloids from European mistletoe (Viscum album L.)

Amer

Juvik

Dupont

et al. 2012

Phytochemistry Letters

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Mass spectrometry (MS) 3.5 Biological activity 3.5.1 15-Lipoxygenase inhibition 3.5.2 DPPH scavenging activity 3.5.3 Artemia toxicity test 4. Results and discussion 4.1. Novel aminoalkaloids and GHB-derived natural products from European white-berry mistletoe (Viscum album L.) 4.2. A novel dihydrostilebenoid glucoside and seven other natural products isolated from dawn redwood (Metasequoia glyptostroboides Hu & Cheng) 4.3. A novel acylated C-glycosylflavone and six other natural products from Zamioculcas zamiifolia 4.4. Twenty non-polar natural products from three Bromeliaceae spp. 4.5. Novel aromatic compounds from Narthecium ossifragum L. References I wish to thank my main supervisor Professor Torgils Fossen for excellent supervision. Fossen has willingly shared of his knowledge and encouraged me in the daily struggle of making procedures work and figuring out the meaning of the results. Assistant supervisor Professor Svein Haavik has provided valuable discussions and input at critical stages during the development of the thesis. Professor Emeritus George W. Francis has most kindly used some of his time to discuss with me and share of his knowledge accumulated through more than four decades of natural products research. Francis has also contributed to improvement of language of both papers and thesis. Special word of thanks to Professor Jackson Roberto Guedes da Silva Almeida (UNIVASF, Brazil), Professor Frederic Dupont (Universite Lille 2) and Professor Dag Olav Øvstedal (University of Bergen) for providing significant quantities of the plant material used in this thesis. All co-authors on papers included in the thesis are appreciated for their collaboration and valuable contributions. Dr. Bjarte Holmelid and Mr. Terje Lygre have my gratitude for the recording of high-resolution mass spectra. Now retired principal engineer Atle Aaberg have my gratitude for his technical assistance. I wish to thank all the people at the Department of Chemistry including past and current members of the research group in Pharmacognosy. You have all contributed to a friendly, inspiring and good working environment. Colleagues and my two closest superiors, apothecary Kine Risberg and manager Rikke Landsvik Berge at Apotek1 Oasen have my deepest gratitude. Their friendly attitude and flexibility has made it possible to continue writing papers and completing the thesis during the two years from August 2015 to September 2017 next to a full time job as pharmacist. Open Access publication of paper VI "Non-polar natural products from Bromelia laciniosa, Neoglaziovia variegata and Encholirium spectabile (Bromeliaceae)" were kindly funded by Centre for Pharmacy, University of Bergen.

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“…Previously we have reported various biologically active secondary metabolites from Metasequoia glyptostroboides along with their potent biological and therapeutic potential [5][6][7]. The aim of this research is to confirm the biological and therapeutic potential of taxodone as a potent inhibitor of tyrosinase and a-glucosidase in vitro.…”

mentioning

confidence: 91%

Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia glyptostroboides

Bajpai

Kang

2015

Natl. Acad. Sci. Lett.

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In this study, a diterpenoid compound taxodone, isolated from Metasequoia glyptostroboides was evaluated for tyrosinase and a-glucosidase inhibitory effects in terms of its potent anti-melanogenesis and antidiabetic potential, respectively. As a result, taxodone at the concentration range of 200-1,000 and 100-3,000 lg/ml showed potent efficacy on inhibiting tyrosinase and aglucosidase enzymes in vitro by 11.08-49.32 and 10.11-50.62 %, respectively. These findings confirm the therapeutic potential of diterpenoid compound taxodone from M. glyptostroboides as a novel candidate for using in food and medicine industry with a potential of skin whiting agent and to treat diabetes mellitus type II related disorders.

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Antimycotic potential of a diterpenoid taxoquinone against <i>Candida</i> species isolated from <i>Metasequoia glyptostroboides</i>

Cited by 7 publications

References 17 publications

Growing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng—a molecular reservoir from the ancient world with potential in modern medicine

Growing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng—a molecular reservoir from the ancient world with potential in modern medicine

Novel aminoalkaloids from European mistletoe (Viscum album L.)

Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia glyptostroboides

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