Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia glyptostroboides

Bajpai, Vivek K.; Kang, Sun Chul

doi:10.1007/s40009-015-0383-3

Cited by 7 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The p-values in these graphs were calculated using independent two-tailed T-test, where 0.05 is the threshold for significance. From S. africana lutea, six abietane diterpenes were isolated and identified as 19-acetoxy-12-methoxycarnosic acid (1), 3β-acetoxy-7α-methoxyrosmanol (2), 19-acetoxy-7α-methoxyrosmanol (3), 19-acetoxy-12-methoxy carnosol (4), clinopodiolides A (5), and B (6), in addition to three triterpenes, oleanolic and ursolic acids (7,8) and β-amyrin (9) [19][20][21][22][23][24].…”

Section: Resultsmentioning

confidence: 99%

Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species

et al. 2020

View full text Add to dashboard Cite

The prevalence of diabetes mellitus (DM), considered one of the most common metabolic disorders, has dramatically increased and resulted in higher rates of morbidity and mortality around the world in the past decade. It is well known that insulin resistance in target tissues and a deficiency in insulin secretion from pancreatic β-cells are the main characteristics of type 2 diabetes. The aim of this study was the bio-evaluation of compounds isolated from three selected plant species: namely, Salvia africana-lutea, Leonotis ocymifolia, and Plectranthus madagascariensis, for their glucose-uptake ability. Methanolic extracts were produced from the aerial parts of each plant. Compounds were identified using different spectroscopic techniques. The glucose-uptake ability of each compound was then evaluated in mammalian cells using 2-deoxyglucose-6-phosphate. The cytotoxicity of each compound was established via the MTT assay. Chromatographic purification of the three plant species yielded sixteen pure terpenoids. Compounds 1 (p = 0.0031), 8 (p = 0.0053), and 6 (p = 0.0086) showed a marked increase in glucose uptake, respectively. Additionally, 1, 4, and 6 exhibited cytotoxicity toward mammalian tissue with a decrease in cell viability of ~70%, ~68%, and ~67%, respectively. The results suggested that several compounds demonstrated a marked increase in glucose uptake, while two of the compounds exhibited signs of cytotoxicity. It may, therefore, be suggested that these compounds be considered as potential candidates for novel plant-derived alternative therapies in the treatment of type 2 diabetes.

show abstract

Section: Resultsmentioning

confidence: 99%

Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Totarol has proved to have antifungal activity against fungi from cereal crops, 41 and sugiol has also exhibited inhibitory effects on different Candida species. 42 Therefore, they could be responsible for the effectiveness of the enzymatic treatment. However, these extracts may contain other compounds that could be involved.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In the literature, both of them have been reported to have biological activity. Totarol has proved to have antifungal activity against fungi from cereal crops, and sugiol has also exhibited inhibitory effects on different Candida species . Therefore, they could be responsible for the effectiveness of the enzymatic treatment.…”

Section: Resultsmentioning

confidence: 99%

A Sustainable Treatment for Wood Preservation: Enzymatic Grafting of Wood Extractives

Fernández‐Costas

Palanti

Charpentier³

et al. 2017

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Natural extractives are proposed as potential sustainable bioactive compounds for wood preservative formulations, and an enzyme-mediated reaction is employed to fix them onto the wood surface. This environmentally friendly process takes place thanks to the activity of the laccase enzyme and leads to the formation of covalent bonds between these compounds and the wood itself. This then diminishes the problem of its future leaching, giving rise to long-lasting wood protection treatments. Overall, our data show suitable biocidal properties for the raw extracts of Pinus spp. and Criptomeria japonica. Phenolic compounds such as pinosylvin, pinosylvin monomethyl ether, pinocembrin, naringenin, and pinobanksin were found in the extracts of pine together with totarol and sugiol in the C. japonica extract and could explain the antifungal properties found. Fungal tests have revealed mass losses below 7% for wood treated with the toluene extracts of Pinus spp. and the ethanolic extract of C. japonica, pointing to this enzymatic green methodology as a promising alternative in the wood preservation field. Therefore, potential inclusion of these enzymatic strategies in the wood industry today is discussed and analyzed in a "green" scenario.

show abstract

“…It catalyzes the breaking down of the reaction of disaccharides and starch to glucose [37]. Glucosidase inhibitors decrease the rate of carbohydrate digestion and retard carbohydrate absorption from the alimentary tract [38]. In the search for effective hypoglycemic candidates from natural sources, a great deal of research is being carried out to identify phytoconstituents having a hypoglycemic effect with emphasis on the inhibition of alpha-glucosidase and alpha-amylase.…”

Section: Alpha-glucosidase and Alpha-amylase Activitymentioning

confidence: 99%

In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents

et al. 2022

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more effective antidiabetic drugs with fewer side effects. Natural products are a well-known source for the discovery of new scaffolds for drug discovery, including new antidiabetic drugs. The genus Helichrysum has been shown to produce antidiabetic natural products. In this investigation, the methanolic extract of H. cymosum and H. pandurifolium resulted in the isolation and identification of eleven known compounds viz 5,8-dihydroxy-7-methoxy-2-phenyl flavanone (1), pinostrobin (2), dihydrobaicalein (3), glabranin (4), allopatuletin (5), pinostrobin chalcone (6), helichrysetin (7), 5-hydroxy-3,7-dimethoxyflavone (8), 3,5-dihydroxy-6,7,8-trimethoxyflavone (9), 3-O-methylquercetin (10), and 3-methylethergalangin (11). The in vitro bio-evaluation of isolated compounds against alpha-glucosidase showed that 10, 5, and 11 demonstrated the highest alpha-glucosidase inhibitory activity with IC50 values of 9.24 ± 0.4, 12.94 ± 0.2, and 16.00 ± 2.4 μM respectively, followed by 7 and 3 with IC50 values of 18.16 ± 1.2 and 44.44 ± 0.2 μM respectively. However, none of these compounds showed a measurable inhibitory effect on alpha-amylase under the experimental conditions used except compound 10 which showed a poor alpha-amylase inhibitory activity with an IC50 value of 230.66 ± 15.8 μM. Additionally, strong total antioxidant capacities were demonstrated by 10, 5 and 7 in ferric-ion reducing antioxidant power assay (374.34 ± 69.7; 334.37 ± 1.7; 279.93 ± 0.8) µmol AAE/mmol. This is the first scientific report to be carried out on alpha-glucosidase inhibitory activities and antioxidant capacities of H. cymosum constituents and a first report on the isolation and identification of methoxyflavanoids from H. pandurifolium. Our findings suggest that these compounds are promising candidates to inhibit alpha-glucosidase as well as oxidative stress related to diabetes. Results from molecular docking provided insight into the observed in vitro alpha-glucosidase inhibitory activities for 5, 7, 10, and 11. It is envisaged that the isolated phytochemicals from these plants may contribute to the development of hypoglycemic lead compounds with anti-diabetic potential.

show abstract

Tyrosinase and α-Glucosidase Inhibitory Effects of an Abietane Type Diterpenoid Taxodone from Metasequoia glyptostroboides

Cited by 7 publications

References 16 publications

Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species

Glucose-Uptake Activity and Cytotoxicity of Diterpenes and Triterpenes Isolated from Lamiaceae Plant Species

A Sustainable Treatment for Wood Preservation: Enzymatic Grafting of Wood Extractives

In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents

Contact Info

Product

Resources

About