Antimutagens from Momordica charantia

Guevara, Amelia; Lim-Sylianco, Clara Y.; Dayrit, Fabian M; Finch, Paul

doi:10.1016/0027-5107(90)90050-e

Cited by 39 publications

(11 citation statements)

References 7 publications

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“…At maturity, the fruit splits into three irregular valves that curl backwards and release numerous reddish-brown seeds. Biological actions of various extracts of the plants or its constituents include antidiabetic (Ahmed et al, 1998;Mastuda et al, 1999;Raza et al, 2000), anti ulcerogenic (Gürbüz et al, 2000), antimutagenic (Guevara et al, 1990), antioxidant (Scartezzini & Speroni, 2000), anti-tumour (Lee-Huang et al, 1995a), immunomodulatory (Spreafico et al, 1983). Two proteins known as α -and β -monorcharin which are present in the seeds, fruits and leaves have shown to inhibit the human immune deficiency virus (HIV) in vitro (Zhang, 1992;LeeHuang et al, 1995b).…”

Section: Introductionmentioning

confidence: 99%

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Patil

2011

Int. J. Morphol.

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Section: Introductionmentioning

confidence: 99%

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Patil

2011

Int. J. Morphol.

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“…Several medicinal properties of the bitter gourd have been studied by various researchers that include anti-diabetic [22][23][24], anti-ulcerogenic [25], anti-mutagenic [26], antioxidative [27], anti-tumour [28], immune-modulatory acivities [29] etc. In vitro studies reveals that the bitter gourd proteins (α -and β-monorcharin) have inhibitory effect against human immune deficiency virus (HIV).…”

Section: Pharmacological and Medicinal Usesmentioning

confidence: 99%

Nutritional, Pharmacological and Medicinal Properties of Momordica Charantia

Kumar¹,

Nallamuthu²

2015

IJNFS

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Abstract:Momordica charantia L. (Bitter gourd) is a flowering vine in the family of Cucurbitaceae. It contains an array of novel and biologically active phytochemicals including triterpenes, proteins and steroids. Medicinally, the plant has a long history of use by the indigenous people as a folk medicine. Bitter gourd is often used in Chinese cooking for its bitter flavor, typically in stir-fries, soups, and also as tea. Pakistan, Philippines, Panama and Nepal also use this bitter vegetable for culinary purposes in addition to India. Several medicinal properties of the bitter gourd have been studied by various researchers, such as anti-diabetic, anti-ulcerogenic, anti-mutagenic, antioxidant, anti-tumour, anti-lipolytic, analgesic, abortifacient, anti-viral, hypoglycemic and immunomodulatory. In vitro studies reveals that the bitter gourd proteins (α-and β-monorcharin) have inhibitory effect against HIV virus, and leaf extracts have broad-spectrum anti-microbial activity as well. Many in vivo studies have demonstrated the relatively low toxicity of all parts of the bitter gourd plant when ingested orally. This review also addresses taxonomy, phytochemical, culinary practices and pharmacological properties in detail. Over the years scientists have verified many of the traditional uses of this bitter plant that continues to be an important natural remedy in herbal medicine systems. Bitter gourd products such as concentrated fruit and seed extracts can be found in capsules and tablets, as well as in whole herb/vine powder forms and these supplements are becoming more widely available in many countries nowadays as prophylactic or therapeutic agents.

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“…İleti şim (Correspondence) +90 224 2940839 ngul@uludag.edu.tr , antiviral 9 , cytotoxic 10 , hypoglycemic 11 and antimutagenic 12 , and also antidiabetic, antileukemic, antibacterial, anthelmintic, antimycobacterial, antioxidant, antiulcer, antiinflammatory, hypotensive, immunostimulant, and insecticidal properties [13][14][15][16][17] . Recently, M. charantia is cultivated in the fields at Marmara region (western Anatolia) 17 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Bitter Melon (Momordica charantia) and Gotu Kola (Centella asiatica) Extracts on Healing of Open Wounds in Rabbits

Satar¹,

Topal²,

Yanik³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThis study investigated the eff ects of topically applied oily homogenized and powder forms of bitter melon (Momordica charantia) (MC) and ointment formulation of gotu kola (Centella asiatica) (CA) extract and compared the results with untreated control and pure olive oil groups on wound healing in rabbits. A total of 30 New Zealand rabbits were divided into five equal groups (oily homogenized form of MC, powder form of MC, ointment of CA, control, pure olive oil). Full-thickness 5x5 cm skin wounds were created on the right mid-dorsum area and experimental groups were treated daily with the above mentioned extracts. Wounds were observed daily. Planimetry was performed for the unhealed wound area and the percentage of total wound healing on days 0, 7, 14, 21 and 28. Median time for the first observable granulation tissue was shorter in all experimental groups than in the control group (P<0.05). Filling of the open wound to skin level with granulation tissue was faster in the oily homogenized form of MC and ointment of titrated extract of CA groups (P<0.05). The average time for healing was shorter in the oily homogenized form of MC and ointment of titrated extract of CA groups than in other groups (P<0.05). The results demonstrate that topical application of the oily form of MC and ointment form of CA results in significant improvements on wound healing in rabbits. Keywords: Wound healing, Rabbit, Momordica charantia, Centella asiaticaTavşanlarda Kudret Narı (Momordica charantia) ve Gotu Kola (Centella asiatica) Ekstraktlarının Açık Yara İyileşmesi Üzerine Etkilerinin Karşılaştırılması ÖzetBu çalışmanın amacı; tavşanlarda açık yara iyileşmesinde topikal Momordica charantia'nın (MC) yağlı homojenize formu ve toz formları ile Centella asiatica (CA) ekstratının pomat formunun etkilerini araştırmak, saf zeytinyağı uygulanan ve sağaltım uygulanmayan kontrol grubu ile karşılaştırmaktı. Bu çalışmada kullanılan otuz adet Yeni Zelanda tavşanı 5 gruba ayrıldı: MC'nın yağlı homojenize formu, MC'nın toz formu, CA'nın titre edilmiş ekstratının pomat formu (Madécassol® pomat), kontrol ve saf zeytinyağı. Her bir tavşanda dorsal orta hattın sağ tarafında tam kalınlıkta deriyi kapsayan birer yara (5x5 cm) oluşturuldu ve yukarıda belirtilen ekstratlarla tedavi uygulandı. Yaralar günlük olarak izlendi ve 0, 7, 14, 21 ve 28. günlerde iyileşmemiş yara alanı ve total yara iyileşme yüzdesini ölçmek için planimetri uygulandı. İlk gözlenebilir granulasyon dokusu için ortalama zaman; tüm deney gruplarında kontrol grubundan daha kısa bulundu (P<0.05). Yara yatağının granulasyon dokusu ile deri düzeyine kadar dolması; MC yağlı homojenize formu ve CA titre edilmiş ekstratının pomat formu uygulanan gruplarda diğer gruplardan daha hızlı idi (P<0.05). Ortalama iyileşme zamanı, MC yağlı homojenize formu ve CA titre edilmiş ekstratının pomad formu uygulanan gruplarda, diğer gruplardan daha kısa idi (P<0.05). Bu çalışmada elde edilen sonuçlar; MC yağlı homojenize formu ve CA ekstratının pomad formunun topikal uygulamasının, tavşanlarda açık...

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Antimutagens from Momordica charantia

Cited by 39 publications

References 7 publications

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Nutritional, Pharmacological and Medicinal Properties of Momordica Charantia

Comparison of the Effects of Bitter Melon (Momordica charantia) and Gotu Kola (Centella asiatica) Extracts on Healing of Open Wounds in Rabbits

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