Antimicrobial susceptibility patterns of community-acquired uropathogens in Tehran, Iran

Abstract

Background: Antibiotic resistance of urinary tract pathogens has increased worldwide. Knowledge of the antibiotic resistance patterns of uropathogens in specific geographical locations is an important factor for choosing an appropriate empirical antimicrobial treatment. The aim of this study was to provide information regarding local resistance patterns of urinary pathogens to the commonly used antibiotics in Tehran, Iran. Methodology: Urine samples collected and submitted to two pathobiology laboratories in Tehran were identified by conventional methods over a period of three years (December 2006 to May 2009). Antimicrobial resistance testing was performed by the standard disk diffusion technique in accordance with the recommendations of the Clinical and Laboratory Standards Institute. Results: Of the total 13,333 mid-stream urine samples collected from suspected cases of urinary tract infection, 840 (6.3%) were positive for pathogenic bacteria. Escherichia coli (E. coli) was the most common isolate (68.8%) followed by Proteus spp. (12.4%), and Klebsiella spp. (9.6%). E. coli isolates were mostly susceptible to nitrofurantoin (71.3%), followed by ciprofloxacin (68.1%); however, only 38.2% of E. coli isolates were susceptible to trimethoprim-sulfamethoxazole. Conclusion: Nitrofurantoin may be considered as a first-line empiric antibacterial agent for urinary tract infections in outpatients in Tehran, Iran.

Incidence and Antibiotic Susceptibility Pattern of Most Common Bacterial Pathogen Causing Urinary Tract Infection (UTI) in Tehran, IRAN, 2012-2013

“…Discoveries indicated that lineages of E-coli are sensitive to this antibiotic respectively 66% and 2.62%. These results were the same as other Iranians researches (11). This findings showed that using Fluoroquinolones in treatments should seriously be controled and an efficient strategy to counter and stop the increased resistance of this antibiotic should be considered.…”

“…Urinary tract infection is one of the most common medical problems in females and also in this study a large portion of patients consisted of females (36.84%). This number is very close to pathfinder's and his/her colleagues (11) and Rostam zade khamene (12) results. As we expected based on previous studies (13,14) Escherichia coli has the highest frequency among pathogens (57.64%).…”

Multi Drug Resistant Pathogens Causing Urinary Tract Infections in Children at Kathmandu Model Hospital

“…Our study also showed the similar fi ndings with 28.5-30.35% resistance to quinolones, 39.2-50.0% resistance to cephalosporins and 48.21% resistance to cotrimoxazole for gram negative isolates 17 . The results showed a considerable increase in resistivity of gram negative isolates to amoxycillin (80.36%) which was supported by several studies 11,12,18 . Nitrofurantoin demonstrated better activity against gram negative (98.21% susceptible) as well as gram positive isolates (100.0% susceptible), in agreement with data published by others 17,18,19 .…”

“…The results showed a considerable increase in resistivity of gram negative isolates to amoxycillin (80.36%) which was supported by several studies 11,12,18 . Nitrofurantoin demonstrated better activity against gram negative (98.21% susceptible) as well as gram positive isolates (100.0% susceptible), in agreement with data published by others 17,18,19 . The high level susceptibility of uropathogens to nitrofurantoin may be the narrow spectrum of activity, narrow tissue distribution (low or undetectable serum concentration) and limited contact with bacteria outside the urinary tract 20 .…”

Bacterial Etiologies and Antibiotic Susceptibility Pattern of Urinary Tract Infections at the Pediatric Ward of Dastgheib Hospital, Shiraz, Iran: A Three-Year Study (2009 - 2011)

“…Urinary tract infection (UTI) is one of the common infections in pediatric wards, worldwide (1,2). Urinary tract infection can be nosocomial or community acquired (3). It is defined as the growth of > 10 5 CFU/mL of a single pathogen from properly collected urine specimen of children with febrile disease or UTI symptoms (4).…”