Antimicrobial susceptibility of Pasteurella multocida isolated from swine and poultry

Abstract

Pasteurella multocida causes infectious diseases in a wide range of animal species. Antimicrobial therapy is still an effective tool for treatment. Generally, P. multocida isolates are susceptible to most of the widely used commercial antimicrobial agents but their excessive and unjustified use accelerates the emergence of resistant strains. We defined the antimicrobial sensitivity pattern of 56 P. multocida strains isolated from poultry (20) and swine [16 P. multocida toxin (PMT) positive and 20 PMT negative] to 16 widely applied antibiotics (apramycin, cefquinome, chloramphenicol, colistin, doxycycline, enrofloxacin, erythromycin, florfenicol, flumequine, neomycin, oxolinic acid, penicillin, trimethoprim potentiated sulphamethoxazole, sulphonamide compounds, tetracycline, tulathromycin) by the disk diffusion method. The majority of the strains was susceptible to most of the antimicrobial agents tested. However, the resistance to sulphonamides, tetracyclines, first-generation quinolones and aminoglycosides was remarkable, and thus the use of these compounds for the treatment of infection caused by P. multocida is not recommended. On the other hand, the antimicrobial activity of the classical penicillin, the newer macrolide (tulathromycin), the third-generation fluoroquinolone (enrofloxacin) and the fourth-generation cephalosporin (cefquinome) proved to be satisfactory against this bacterium.

Outer membrane vesicles of Pasteurella multocida contain virulence factors

“…This result is in good agreement with a previous study performed by Sellyei et al. () to test the susceptibility of P. multocida isolated from chickens and pigs to antimicrobial agents. In that study, the authors found that the majority of P. multocida strains tested were susceptible to penicillin.…”

Multidrug Resistant Bacteria in the Respiratory Tract of Apparently Healthy Quails

“…Our findings contradict the finding of Morishita et al (1996) who reported that P. multocida isolates were susceptible to erythromycin, sulphamethoxazole and tetracycline. Sellyei et al (2009) reported that P. multocida isolates of poultry were resistant to sulphonamide and tetracycline. Bacillus sp.…”

Molecular Basis of Macrolide, Triamilide, and Lincosamide Resistance in Pasteurella multocida from Bovine Respiratory Disease

“…Antimicrobial agents are commonly applied to control respiratory tract infections in cattle (9,14). Based on the available susceptibility data, most bovine P. multocida strains are still susceptible to newer antimicrobial agents, including the 15-membered ring macrolide tulathromycin (4,7,16). Since tulathromycin has a unique chemical structure characterized by the presence of three amine groups, it has been referred to in the literature as the first representative of the triamilide subclass among the macrolides (3).…”