Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis

Souza, Eduardo Quintão Manhanini; Rocha, Tiago Esgalha da; Toro, Luan Felipe; Guiati, Isabella Zacarin; Ervolino, Edílson; Garcia, Valdir Gouveia; Wainwright, Mark; Theodoro, Letícia Helena

doi:10.1016/j.pdpdt.2020.101808

Cited by 29 publications

(23 citation statements)

References 36 publications

(120 reference statements)

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“…Whether aPTD is more effective than antibiotics as an adjunct to scaling and root planning is still debatable [56]. In a meta-analysis study, Souza et al compared aPDT with systemic antibiotic use as adjuncts to SRP, and found similar improvement in the clinical status for both proposed treatments [57]. A 2019 systematic review analyzed whether SRP plus antimicrobial photodynamic therapy exerted an improved clinical outcome in comparison to SRP plus systemic antibiotics in periodontal disease.…”

Section: Antibiotics Vs Antimicrobial Photodynamic Therapy (Apdt)mentioning

confidence: 99%

Clindamycin as an Alternative Option in Optimizing Periodontal Therapy

et al. 2021

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Periodontal disease is an oral infectious and inflammatory disease caused by microorganisms that determine the host-mediated destruction of soft and hard periodontal tissues, which ultimately leads to tooth loss. Periodontitis affects a large part of the population, with various degrees of severity. Treatment consists of etiologic therapy: the removal of biofilm through mechanical debridement plus microbial elimination by supplementary measures. Antibiotic administration, either systemically or through local delivery, has been shown to improve clinical outcomes after mechanical periodontal treatment. Clindamycin is a lincosamide with a broad spectrum, being active against aerobic, anaerobic, and β-lactamase-producing bacteria. This antibiotic offers several advantages and some disadvantages and has been used in periodontal treatment both systemically and locally with various degrees of success. Among the properties that recommend it for periodontal treatment is the bacteriostatic effect, the inhibition of bacterial proteins synthesis, the enhancement of neutrophil chemotaxis, phagocytosis and the oxidative burst–oxidative stress storm. Furthermore, it is easily absorbed at the level of oral tissues in a considerable amount. This substantial tissue penetration, especially inside the bone, is synergistic with a stimulating effect on the host immune system. The aim of this review is to explore the applicability of this antibiotic agent and to evaluate its antimicrobial potential and limitations at the level of the oral biofilm associated with periodontal disease.

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Section: Antibiotics Vs Antimicrobial Photodynamic Therapy (Apdt)mentioning

confidence: 99%

Clindamycin as an Alternative Option in Optimizing Periodontal Therapy

et al. 2021

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“…PDT can be applied for disinfection and sterilization [4][5][6][7]. Microbial, including bacterium and viruses can be removed by photosensitized reaction.…”

Section: Electron Transfer Mechanism and Antimicrobial Photodynamic Tmentioning

confidence: 99%

“…This treatment is a medicinal application of photochemistry. Antimicrobial treatment, called as antimicrobial photodynamic therapy (aPDT) or photodynamic antimicrobial chemotherapy (PACT), is also important application [4][5][6][7]. In the case of cancer treatment, less-toxic PDT reagents, photosensitizers, cause oxidative damage to biomolecules, including protein, nucleic acids, and/or other compounds, under visible-light irradiation.…”

Section: Introductionmentioning

confidence: 99%

Electron Transfer-Supported Photodynamic Therapy

Hirakawa¹

2021

Photodynamic Therapy - From Basic Science to Clinical Research

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Photodynamic therapy (PDT) is a less-invasive treatment of cancer and precancerous lesions. Porphyrin derivatives have been used and studied as the photosensitizers for PDT. In general, the biomacromolecules oxidation by singlet oxygen, which is produced through energy transfer from the photoexcited photosensitizers to oxygen molecules, is an important mechanism of PDT. However, the traditional PDT effect may be restricted, because tumors are in a hypoxic condition and in certain cases, PDT enhances hypoxia via vascular damage. To solve this problem, the electron transfer-mediated oxidation of biomolecules has been proposed as the PDT mechanism. Specifically, porphyrin phosphorus(V) complexes demonstrate relatively strong photooxidative activity in protein damage through electron transfer. Furthermore, other photosensitizers, e.g., cationic free-base porphyrins, can oxidize biomolecules through electron transfer. The electron transfer-supported PDT may play the important roles in hypoxia cancer therapy. Furthermore, the electron transfer-supported mechanism may contribute to antimicrobial PDT. In this chapter, recent topics about the biomolecules photooxidation by electron transfer-supported mechanism are reviewed.

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“…PDT that targets bacteria in particular is called antimicrobial photodynamic therapy (a-PDT). These therapies are beginning to be used to eliminate bacterial infections in periodontal disease [3][4][5][6], infected root canal treatment [7][8][9][10], and caries treatment [11][12][13][14]. There are three elements required for a-PDT: a photosensitizer, an excitation light, and oxygen.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, there was no statistical difference in the clinical parameters between the group treated with SRP under systemic antibiotics and the group treated with a-PDT and SRP [3] or patients with periodontitis. There was no statistical difference in probing depth (PD) and clinical attachment level (CAL) when conventional periodontal therapy (SRP) and a-PDT were compared in patients with peri-implantitis [5]. In addition to these studies, the effects of a-PDT on antibacterial and inflammatory cytokines have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro

et al. 2021

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Antimicrobial photodynamic therapy (a-PDT) is attracting attention as a new form of dental treatment. While it is primarily applied to produce an antibacterial effect, it decreases lipopolysaccharide (LPS) and protease activity. Here, we evaluated differences in the antibacterial activity of a-PDT on three types of bacteria and the effects on the organic substances (i.e., albumin and LPS). Furthermore, we investigated the effects of a-PDT on root surfaces. A FotoSan630® and toluidine blue were used to perform a-PDT in this study. We measured its antimicrobial activity against Porphyromonas gingivalis, Streptococcus mutans, and Enterococcus faecalis. Antimicrobial testing revealed strong antimicrobial action and P. gingivalis, E. faecalis, and S. mutans were almost undetectable after 50, 120, and 100 s, respectively. In organic resolution tests, albumin was significantly decreased from 1 min after a-PDT application onward, while LPS significantly decreased at 5 min after the application. The root surfaces after a-PDT were confirmed to be cleaner than the controls without suffering any damage. Depending on the bacterial species, a-PDT exhibited antimicrobial activity against various types of bacteria and sensitivity differed. Moreover, we reported that a-PDT resolves protein and LPS, enabling the formation of a healthy root surface without any damage.

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Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis

Cited by 29 publications

References 36 publications

Clindamycin as an Alternative Option in Optimizing Periodontal Therapy

Clindamycin as an Alternative Option in Optimizing Periodontal Therapy

Electron Transfer-Supported Photodynamic Therapy

Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro

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