Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial

Ivanaga, Camila Ayumi; Miessi, Daniela Maria Janjácomo; Nuernberg, Marta Aparecida Alberton; Cláudio, Marina Módolo; Garcia, Valdir Gouveia; Theodoro, Letícia Helena

doi:10.1016/j.pdpdt.2019.07.005

Cited by 28 publications

(27 citation statements)

References 53 publications

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“…To date, there are no published human clinical trials using 5-aminolevulinic acid, rose Bengal and erythrosine as photosensitizers in the dental fields. Notwithstanding, for curcumin, there are recent human clinical trials that reported using LEDs as the light source, and with promising results obtained [ 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

et al. 2020

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Background: Antimicrobial photodynamic therapy (aPDT) has been proposed as an effective alternative method for the adjunctive treatment of all classes of oral infections. The multifactorial nature of its mechanism of action correlates with various influencing factors, involving parameters concerning both the photosensitizer and the light delivery system. This study aims to critically evaluate the recorded parameters of aPDT applications that use lasers as the light source in randomized clinical trials in dentistry. Methods: PubMed and Cochrane search engines were used to identify human clinical trials of aPDT therapy in dentistry. After applying specific keywords, additional filters, inclusion and exclusion criteria, the initial number of 7744 articles was reduced to 38. Results: Almost one-half of the articles presented incomplete parameters, whilst the others had different protocols, even with the same photosensitizer and for the same field of application. Conclusions: No safe recommendation for aPDT protocols can be extrapolated for clinical use. Further research investigations should be performed with clear protocols, so that standardization for their potential dental applications can be achieved.

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Section: Discussionmentioning

confidence: 99%

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

et al. 2020

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“…Oral decontamination of orthodontic patients was achieved by APDT using blue light and curcumin and promoted with sodium dodecyl sulfate surfactant [ 64 ]. In addition, Ivanaga et al [ 65 ] performed curcumin-based APDT as an adjunct therapy in combination with scaling and root planing to treat residual pockets in patients with diabetes. Additionally, Staphylococcus spp.…”

Section: Preclinical and Clinical Apdt Studiesmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Polat

Kang

2021

Biomedicines

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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“…Ivanaga et al (27) discussed that in patients with type 2 diabetes mellitus, the treatment of residual pockets (with PD ≥5 mm and BOP) with antimicrobial photodynamic therapy with 100 mg/L curcumin solution and LED irradiation as adjunctive therapy to scaling and root planing, may yield short-term (three months) clinical benefits regarding clinical attachment gain.…”

Section: Methodsmentioning

confidence: 99%

The efficacy of herbal medicine on gingival and periodontal diseases: a review

Baghizadeh¹,

Aghayan

Rahati³

et al. 2021

J Res Dent Maxillofac Sci

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Background and Aim:The most common etiology of gingivitis is accumulation of bacterial plaque. Complete removal of microbial plaque by mechanical procedures is not possible in some cases; for example, aged and disabled patients might not be capable of removing the bacterial plaques properly. Also, chemical mouthwashes have some adverse effects. Therefore, finding a new treatment approach would be helpful. The global focus on the use of herbal medicine for treatment of different health conditions is on the rise. The present study aimed at searching and collecting scientific evidence regarding medicinal herbs to treat gingivitis and periodontitis. Materials and Methods: In this review, an electronic search of the literature was conducted through PubMed, Scopus, Google Scholar, and Wiley online library databases. Studies were considered for inclusion if they evaluated medicinal herbs affecting gingival and periodontal inflammation or periodontal pathogens. Totally, 197 full-text articles were evaluated and finally, based on the inclusion criteria, 22 articles were selected. Results: There are various medical herbs with antibacterial and anti-inflammatory properties, which can significantly decrease gingival and periodontal inflammation, bleeding on probing (BOP), plaque index (PI), probing depth (PD) and the count of major periodontal pathogens, and promote clinical attachment gain. Conclusion:The introduced herbal products could be an efficient and safe alternative to chemical products.

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Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial

Cited by 28 publications

References 53 publications

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

The efficacy of herbal medicine on gingival and periodontal diseases: a review

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