Antimicrobial investigation of ethnobotanically selected guinean plant species

Baldé, Mamadou Diouldé; Tuenter, Emmy; Traoré, Mohamed Sahar; Matheeussen, An; Cos, Paul; Maes, Louis; Camara, A.; Haba, N. L. Haba N. L.; Gomou, Kalaya; Diallo, Mamadou Saliou; Baldé, E.S.; Pieters, Luc; Baldé, A.M.; Foubert, Kenn

doi:10.1016/j.jep.2020.113232

Cited by 11 publications

(8 citation statements)

References 55 publications

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“…It sets out in four regions, which are quite distinct and heterogeneous from a geo-ecological point of view: Low Guinea, an area of littoral plains; Middle Guinea, with mountainous solid masses and lateritic high plateaus, Upper Guinea, a vast plateau and Forest Guinea, a true chain of mountains. The global population was estimated at 12,771,246 habitants in 2019, with an average density of 51.91 per km 2 (Baldé et al, 2020). The main ethnic groups are Soussous (Low Guinea), Peuhls (Middle Guinea), Malinkees (Upper Guinea), Kissis, Tomas and Guerzees (Forest Guinea).…”

Section: Study Locationmentioning

confidence: 99%

Ethnobotanical survey of medicinal plants used to manage hypertension in the Republic of Guinea

Traore¹,

Camara²,

Baldé³

et al. 2022

J Pharm Pharmacogn Res

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Context: Like many other African countries, medicinal plants are widely used in Guinea to manage hypertension, which is a highly prevalent health problem. Aims: To identify the plants used in the traditional management of hypertension in Guinea. Methods: From May to November 2018, three hundred and forty-nine Traditional Health Practitioners (THPs) respondents, including 244 traditional healers and 105 herbalists, were contacted. Through semi-structured interviews, ethnobotanical information on medicinal plants were collected. Voucher specimens were authenticated by the department of Botany of the IRDPMAG and deposited in the Herbarium of this Institute. Results: Among the traditional anti-hypertensive recipes, a total of 97 plant species from 85 genera belonging to 43 families have been identified. Combretum micranthum, Hymenocardia acida, Anacardium occidentale, Spondias mombin and Alchornea cordifolia were the most frequently cited. The traditional recipes included one plant species (23 recipes), a combination of two species (18 recipes) or more (47 recipes). Conclusions: A large number of medicinal plants are used for the management of arterial hypertension in Guinea. Further biological and phytochemical investigations are needed to validate the traditional uses of these plants.

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Section: Study Locationmentioning

confidence: 99%

Ethnobotanical survey of medicinal plants used to manage hypertension in the Republic of Guinea

Traore¹,

Camara²,

Baldé³

et al. 2022

J Pharm Pharmacogn Res

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“…From a bioassay-guided fractionation, the highest antiplasmodial activity was obtained for pantolactone with an IC 50 of 0.6 ± 0.03 µM. Good to moderate antiplasmodial activity was obtained with albidic acid B (IC 50 of 6,1 µM), albidic acid C (IC 50 of 6,1 µM), albidienic acid (IC 50 of 6,9 µM), ivorenoside C (IC 50 of 11,3 µM), albidic acid A (IC 50 of 10,1 µM), and 2α,3β,19α,23-tetrahydroxy-11-oxoolean-12-en-28-oic acid 28-Oβ-D-glucopyranosyl ester (13,9 µM) [29].…”

Section: Nomentioning

confidence: 99%

Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe

et al. 2021

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As part of a validation program of antimalarial traditional recipes, an ethnotherapeutic approach was applied in Dionfo, a meso-endemic Guinean rural area where conventional health facilities are insufficient. A prevalence investigation indicated a malarial burden of 4.26%. Ethnomedical and ethnobotanical surveys led to a collection of 63 plant species used against malaria from which Terminalia albida (Combretaceae) was one of the most cited. Ethnotherapeutic evaluation of a remedy based on T. albida was applied to 9 voluntary patients suffering from uncomplicated malaria. Treatment of 7 to 14 days led to an improvement of clinical symptoms and a complete parasite clearance achievement of 8/9 patients without side effects. In addition to antiplasmodial activity in vitro and in vivo previously described, this study indicates an efficacy to support the antimalarial traditional use of T. albida, which could constitute a first-aid treatment when access to other medicines is delayed in the Dionfo community. Ethnotherapeutical investigation could be a valuable approach to guide subsequent investigations on traditional remedies.

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“…The antibacterial drugs meant to resist infectious agents lose their effectiveness due to the accumulating mutations in bacterial species [ 1 ]. Thus antibiotic resistance capability in bacteria eventually becomes very serious in treating pathogenic strains [ 2 , 3 ]. Other morbidities, for instance, cancer, have also been a major cause of death and pose a constant threat worldwide, which is characterized by dysregulation of signalling pathways at multiple steps during cell division.…”

Section: Introductionmentioning

confidence: 99%

“…Taxonomically synonymized as Acer cultratrum wall., Acer laetum C.A. Meyer and Acer pictium , is locally known as kilpattar or Chinaranga in Pallas valley, Kohistan, KP, Pakistan [ 2 , 3 ]. Traditionally, A. cappadocicum improves blood circulation and relieves pain due to injury or rheumatisms [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled

Kausar

Farooqi

et al. 2021

Life

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The appearance of novel microbial resistance, diverse cancer ailment and several other morbidities such as appetite loss, hair loss, anemia, cell damage, etc., are among most critical situation that keeps the phytochemical quest on. Thus, this study characterized the antimicrobial, antioxidant, and anticancer potentials of a rarely accessed Acer cappadocicum gled (AC) population thriving in a remote Palas Valley in northern Pakistan. Leaf extracts of the plant were prepared in organic solvents with different polarities through maceration. Extracts were subjected to antimicrobial, antioxidant, and anticancer activities using agar well, DPPH and cell viability assays. A. cappadocicum methanolic extract (ACM) significantly inhibited bacterial growth, followed by n-butanolic extract (ACB) with the second-highest bacterial inhibition. Similar activity was observed against mycelial growth inhibition in plant-fungal pathogen by ACM and ACB. However, human pathogenic fungi did not affect much by extracts. In antioxidant assessment, the chloroform extract (ACC) showed strong scavenging activity and in cytotoxic evaluation, extracts restricted growth proliferation in cancer cells. The inhibitory evidence of extracts, potent scavenging ability, and low cell viability of human-derived cell lines supports the antimicrobial, antioxidant and anticancerous potential of A. cappadocicum. It advances our quest for natural product research.

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Antimicrobial investigation of ethnobotanically selected guinean plant species

Cited by 11 publications

References 55 publications

Ethnobotanical survey of medicinal plants used to manage hypertension in the Republic of Guinea

Ethnobotanical survey of medicinal plants used to manage hypertension in the Republic of Guinea

Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe

Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled

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