Antimicrobial Hydrogels: Key Considerations and Engineering Strategies for Biomedical Applications

Joshi‐Navare, Kasturi; Eggermont, Loek J.; Rogers, Zachary J.; Mohammed, Halimatu S.; Colombani, Thibault; Bencherif, Sidi A.

doi:10.1007/978-3-030-34475-7_22

Cited by 13 publications

(15 citation statements)

References 178 publications

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“…Of them, hydrogels are cross-linked hydrophilic polymeric networks capable of absorbing large amounts of water or biological fluids. Hydrogel scaffolds are non-toxic and have been widely used for soft tissue reconstruction [12][13][14][15][16][17][18][19][20][21][22][23][24]. However, hydrogels are typically mesoporous, leading to an unfavorable microenvironment that entraps and constrains encapsulated cells, and ultimately preventing their cellular organization in 3D.…”

Section: Introductionmentioning

confidence: 99%

Cryogel-Integrated Biochip for Liver Tissue Engineering

Boulais

Jellali

Pereira

et al. 2021

ACS Appl. Bio Mater.

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Microfluidic systems and polymer hydrogels have been widely developed for tissue engineering. Yet only a few tools combining both approaches, especially for in vitro liver models, are being explored. In this study, an alginate-based cryogel-integrated biochip was engineered for dynamic hepatoma cell line culture in three dimensions (3D). The alginate cryogel was covalently cross-linked in the biochip at subzero temperatures (T < 0 °C) to create a scaffold with high mechanical stability and an interconnected macroporous network. By varying the alginate concentration and the cross-linker ratio, the Young's modulus of the cryogel can be fine-tuned between 1.5 and 29 kPa, corresponding to the range of stiffness of the different physiological states of the liver. We demonstrated that HepG2/C3A cells can be cultured and maintained viable under dynamic conditions in this device up to 6 days.Albumin synthesis and glucose consumption increased over the cell culture days. Moreover, a 3D cell structure was observed across the entire height of the biochip, which was preserved following alginate lyase treatment to remove the cryogel-based scaffold. In summary, these results represent a proof of concept of an interesting new cell culture technology that should be further investigated to engineer healthy and cirrhotic liver models.

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Section: Introductionmentioning

confidence: 99%

Cryogel-Integrated Biochip for Liver Tissue Engineering

Boulais

Jellali

Pereira

et al. 2021

ACS Appl. Bio Mater.

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“…Chemical gels use covalent bonding that provides mechanical integrity and degradation resistance in comparison with other weak materials. In biochemical hydrogels, the gelation process is performed with the involvement of biological agents, as enzymes or amino acids [ 14 ];…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

“…Natural hydrogels are not only biodegradable and biocompatible. For instance, chitosan has become the preferred hydrogel for developing antimicrobial hydrogels of natural origins, as its properties include fast cross-linking [ 14 ]. Hydrogels can be engineered to fit a number of large range application due to their pliability, the possibility to be modulated according to needs [ 14 ].…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

“…Cross-linked polymers (hydrogels) play a fundamental role in the treatment of infectious diseases due to their compatibility with tissues and the loading capacity of different antimicrobials. Hydrogels can serve as antimicrobials, as well as chitosane and other naturally derived polysaccharide [ 14 ]. They can also serve as drug delivery systems for antibiotics, metal nanoparticles [ 15 ], antimicrobial peptides [ 16 ] biological extracts [ 17 ], implant coating to prevent infection [ 18 , 19 ] and carriers for delivery of the CRISPR-Cas9 system for curing the plasmid encoding antimicrobial resistance [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Carpa

Remizovschi

Culda

et al. 2022

Gels

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Antibiotic resistance has increased significantly in the recent years, and has become a global problem for human health and the environment. As a result, several technologies for the controlling of health-care associated infections have been developed over the years. Thus, the most recent findings in hydrogel fabrication, particularly antimicrobial hydrogels, could offer valuable solutions for these biomedical challenges. In this review, we discuss the most promising strategies in the development of antimicrobial hydrogels and the application of hydrogels in the treatment of microbial infections. The latest advances in the development of inherently and composite antimicrobial hydrogels will be discussed, as well as hydrogels as carriers of antimicrobials, with a focus on antibiotics, metal nanoparticles, antimicrobial peptides, and biological extracts. The emergence of CRISR-Cas9 technology for removing the antimicrobial resistance has led the necessity of new and performant carriers for delivery of the CRISPR-Cas9 system. Different delivery systems, such as composite hydrogels and many types of nanoparticles, attracted a great deal of attention and will be also discussed in this review.

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“…Although a moist environment is required at the wound site, it may also increase the risk of microbial infections, which will further extend the wound and/or affect the wound healing process [115]. Microbial colonization is not desired, as it may conduct serious infections, which can result in disease, disability, or even death [116].…”

Section: Active Hydrogels For Treatment Of Burn Wound Dressingsmentioning

confidence: 99%

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

2020

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Globally, the fourth most prevalent devastating form of trauma are burn injuries. Ideal burn wound dressings are fundamental to facilitate the wound healing process and decrease pain in lower time intervals. Conventional dry dressing treatments, such as those using absorbent gauze and/or absorbent cotton, possess limited therapeutic effects and require repeated dressing changes, which further aggravate patients’ suffering. Contrariwise, hydrogels represent a promising alternative to improve healing by assuring a moisture balance at the burn site. Most studies consider hydrogels as ideal candidate materials for the synthesis of wound dressings because they exhibit a three-dimensional (3D) structure, which mimics the natural extracellular matrix (ECM) of skin in regard to the high-water amount, which assures a moist environment to the wound. There is a wide variety of polymers that have been used, either alone or blended, for the fabrication of hydrogels designed for biomedical applications focusing on treating burn injuries. The aim of this paper is to provide an up-to-date overview of hydrogels applied in burn wound dressings.

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Antimicrobial Hydrogels: Key Considerations and Engineering Strategies for Biomedical Applications

Cited by 13 publications

References 178 publications

Cryogel-Integrated Biochip for Liver Tissue Engineering

Cryogel-Integrated Biochip for Liver Tissue Engineering

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

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