Antimicrobial electrospun silk fibroin mats with silver nanoparticles for wound dressing application

Uttayarat, Pimpon; Jetawattana, Suwimol; Suwanmala, Phiriyatorn; Eamsiri, Jarurattana; Tangthong, Theeranan; Pongpat, Suchada

doi:10.1007/s12221-012-0999-6

Cited by 67 publications

(49 citation statements)

References 42 publications

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“…A comparison of the antimicrobial activity of Ag NPs with that of Ag + revealed that Ag NPs are more effective than Ag + because the biocidal activity of Ag NPs is achieved at a lower concentration than what has been observed for Ag + (nmol vs. mmol concentration levels). 32,37 Despite the findings that the use of Ag + and Ag NPs at low concentrations is relatively non-toxic to human cells and causes no serious risk for human health, 9,10,13,[38][39][40][41] dilemmas regarding the safety of Ag for humans and the environment are still present. It was demonstrated that humans can be exposed to Ag particles through different routes, including ingestion, inhalation and absorption through the skin.…”

Section: Antimicrobial Activity Of Silvermentioning

confidence: 99%

Preparation and performance of silver as an antimicrobial agent for textiles: A review

Simončić

Klemenčič

2015

Textile Research Journal

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This article reviews select contemporary silver (Ag) compounds used for the chemical modification of textile fibers, including colloidal Ag, Ag salts, and Ag powder. The routes of their application, the chemical methods of preparation, and the strengths and drawbacks of the individual application processes are reviewed. The most important additives employed in the preparation of colloidal Ag nanoparticle (Ag NP) solutions and their influences on the properties of the colloidal Ag are discussed. Furthermore, the mechanism of the antimicrobial activity of Ag when incorporated into textile fibers is presented in particular. Different factors related to the application processes and the properties of the fibers themselves are addressed in the context of the efficiency of Ag as an antimicrobial agent in textiles.

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Section: Antimicrobial Activity Of Silvermentioning

confidence: 99%

Preparation and performance of silver as an antimicrobial agent for textiles: A review

Simončić

Klemenčič

2015

Textile Research Journal

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“…An ideal candidate for dressing of infectious wounds should deliver sufficiently high concentration of antibiotics to the wound site; mimic the structure and biological function of native extracellular matrix proteins, which provide support and regulate cellular activities; maintain the normal state of differentiation within the cellular compartment; be biocompatible and/or biodegradable; and have no adverse effects on the surrounding tissue. [17][18][19][20][21][22][23][24][25][26][27][28][29] Many of these characteristics can be fulfilled by biocompatible polymer electrospun membranes, loaded with drugs for specific applications.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Poly(lactic acid)/Poly(<I>ε</I>-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering

Valarezo¹,

Tammaro²,

Malagón³

et al. 2015

j nanosci nanotechnol

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Blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL), loaded with different amounts of Amoxicillin antibiotic (AMOX) were electrospun to investigate their release properties and obtain a controlled and tuneable release. The processing parameters for electrospinning were set up and reliable membranes were obtained. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. A very different release kinetics of the two pristine polymers, very rapid for PCL and very slow for PLA, reflected in intermediate release time. However comparing the release amount with that predicted by the mixture rule a preferential incorporation of AMOX into PLA can be inferred.

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“…Polymer blends and composites is an effective method to achieve new obligations for different properties of the materials [1,2]. Currently, electrospinning of blend polymers are inspected as promising materials for biomedical and industrial applications [3][4][5]. Electrospun nanofibers are auspicious materials for many biomedical practices such as drug delivery, wound dressing, and scaffold for tissue engineering [6,7].…”

Section: Introductionmentioning

confidence: 99%

In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

et al. 2015

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Biocompatible crosslinked nanofiber mats of chitosan (CS)/poly(vinyl alcohol) (PVA) were fabricated using electrospinning technique. CS and PVA blends (7, 9 and 11 weight %) of prepared keeping ratios of CS: PVA to 1:4 and was crosslinked with tetraethoxysilane (TEOS). Fourier transform infrared (FTIR) analysis confirmed the existence of inter-and intramolecular hydrogen bonding between polymer chains and the development of siloxane linkage within the nanofibers. Xray diffractometry (XRD) analysis showed an increase in the crystallinity of electrospun nanofibers after crosslinking as compared to the uncrosslinked nanofibers and with an increase in CS/PVA content. Scanning electron microscopy (SEM) micrographs exhibited the formation bead-free fibers at higher polymer concentration. The average size of the nanofibers was found in the range of 40 to 100 nm. The concentration and crosslinker content affected the mechanical and thermal properties of the nanofibers. The crosslinker has increased the tensile strength (TS) values upto 120 % and Young's modulus by 71 % as compared to the uncrosslinked nanofibers while elongation at break was decreased in all nanofibers. The cell viability of the nanofibers was investigated by employing human cancerous bone cells (MG63). The obtained results showed that cancerous bone cells were not proliferated in the presence of nanofibers and the growth of the cells was inhibited confirming the worth of CS/PVA nanofibers against cancerous bone cells. This inherent behaviour can be exploited as base material for anticancer biomedical applications.

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Antimicrobial electrospun silk fibroin mats with silver nanoparticles for wound dressing application

Cited by 67 publications

References 42 publications

Preparation and performance of silver as an antimicrobial agent for textiles: A review

Preparation and performance of silver as an antimicrobial agent for textiles: A review

Fabrication and Characterization of Poly(lactic acid)/Poly(<I>ε</I>-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering

In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

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