Fabrication and Characterization of Poly(lactic acid)/Poly(<I>ε</I>-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering

Abstract

Blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL), loaded with different amounts of Amoxicillin antibiotic (AMOX) were electrospun to investigate their release properties and obtain a controlled and tuneable release. The processing parameters for electrospinning were set up and reliable membranes were obtained. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. A very different release kinetics of the two pristine polymers, very rapid for PCL and very slow for PLA, reflected in intermediate release time. However comparing the release amount with that predicted by the mixture rule a preferential incorporation of AMOX into PLA can be inferred.

Poly(lactic acid) blends in biomedical applications

“…Valarezo et al [88] blended PLA and PCL to attain an optimal release of amoxicillin by attaining an intermediate degradation behavior, compared to the fast degradation of PCL and slow degradation of PLA. As discussed in section 3.2.2, different degradation behavior and the amount of constituent polymers in a blend along with blend morphology determine its degradation profile and hence the release of an incorporated drug.…”

“…Recently, PLA/ poly(N-isopropyl acrylamide)-co-acrylamide blend hydrogels with silver nanoparticles were developed by Prabhakar et al [129], PLA blends have also been explored for film [131][132][133][134] and nanofiber [88,[135][136][137] Recently, gene therapy has emerged as a field with high research activity. PLA has been explored in gene transfection applications after subjection to synthetic modification.…”

Effect of miscibility on mechanical and thermal properties of poly(lactic acid)/ polycaprolactone blends

“…Most of these polymers offer attractive degradation rates in controlled environments, thus avoiding permanent environmental impact. On the other hand, their thermoplastic nature enables easy processing by conventional processes such as melt spinning, injection moulding, extrusion, etc., or other advanced manufacturing processes such as electrospinning, three‐dimensional printing, etc.…”

Investigation of poly(l-lactic acid)/graphene oxide composites crystallization and nanopore foaming behaviors via supercritical carbon dioxide low temperature foaming

“…The excellent biocompatibility and absorbability of PLA have made it suitable for medical applications such as drug delivery systems, sutures and blood vessels. 2 Even through PLA possesses excellent properties, it is still necessary to improve the crystallinity and crystallization rate of PLA to expand its use in broader applications. For example, Drieskens 3 reported that the oxygen and water vapor permeability coefficients of highly crystallized PLA were more than 3-4 times lower than that of the amorphous PLA references.…”