In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

Islam, Atif; Yasin, Tariq; Rafiq, M. A.; Shah, Tahir; Sabir, Aneela; Khan, Shahzad Maqsood; Jamil, Tahir

doi:10.1007/s12221-015-5353-3

Cited by 12 publications

(4 citation statements)

References 28 publications

(46 reference statements)

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“…The formation of uniform fibers increases when the crystallinity of the sample is higher, as is illustrated in Figure 2 . The process of chemical cross-linking through PVA intermolecular interactions with water soluble chitosan are considerable with each of the blended solutions under investigation, in agreement with previous work [ 57 ].…”

Section: Resultssupporting

confidence: 90%

Investigating the Synthesis and Characterization of a Novel “Green” H2O2-Assisted, Water-Soluble Chitosan/Polyvinyl Alcohol Nanofiber for Environmental End Uses

Pervez

Stylios

2018

Nanomaterials

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The present work highlights the formation of a novel green nanofiber based on H2O2-assisted water-soluble chitosan/polyvinyl alcohol (WSCHT/PVA) by using water as an ecofriendly solvent and genipin used as a nontoxic cross-linker. The 20/80 blend ratio was found to have the most optimum uniform fiber morphology. WSCHT retained the same structure as WISCHT. The prepared nanofibers were characterized by Scanning electron microscopy (SEM), Fourier transform spectroscopy (FTIR), Thermo gravimetric analysis (TGA), Differential scanning calorimeter (DSC), X-ray diffraction (XRD), Water Contact Angle (WCA) and Ultraviolet-visible spectroscopy (UV-vis). During electrospinning, the crystalline microstructure of the WSCHT/PVA underwent better solidification and after cross-linking there was an increase in the melting temperature of the fiber. Swelling ratio studies revealed noticeable increase in hydrophilicity with increase of WSCHT, which was further demonstrated by the decrease of contact angle from 64.74° to 14.68°. WSCHT/PVA nanofiber mats exhibit excellent UV blocking protection with less than 5% transmittance value and also showed improved in vitro drug release properties with stable release for longer duration (cross-linked fibers) and burst release for shorter duration (uncross linked) fibers. Finally our experimental data demonstrates excellent adsorption ability of Colour Index (C.I.) reactive black 5 (RB5) due to protonated amino groups.

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Section: Resultssupporting

confidence: 90%

Investigating the Synthesis and Characterization of a Novel “Green” H2O2-Assisted, Water-Soluble Chitosan/Polyvinyl Alcohol Nanofiber for Environmental End Uses

Pervez

Stylios

2018

Nanomaterials

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“…The maximum value of the Young's moduli (360 MPa) obtained from our data is ~ 1.5 times that for the non-radiated fibre. Our values for the Young's moduli are consistent with previously published values for electrospun fibres [41,42,[45][46][47]. For example, incremental stress-strain analysis of single electrospun fibres of poly (ɛ-caprolactone) yields a value of ~ 300 MPa [40].…”

Section: Resultssupporting

confidence: 90%

Modifying the thermomechanical properties of electrospun fibres of poly-vinyl cinnamate by photo-cross-linking

et al. 2018

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We explore the effects of cross-linking on some thermal and mechanical properties of polymer nanofibers of poly-vinyl cinnamate which were electro-spun from 1,2 dichloroethane. Scanning electron microscopy performed on the fibres revealed smooth fibres which were devoid of beading or ribbon-type features. When cross-linked, the Young's moduli and glass transition temperatures of the fibres increase, owing to the formation of new covalent bonds which leads to higher overall binding energies. The glass transition temperatures increased by 20 K after 1 h of photo-polymerization while the Young's modulus increased by 50% for the same exposure time. The glass transition temperatures as well as the heats of enthalpy indicate that a significant portion of cross-linking occurs within the first 10 min of exposure.

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“…Wound healing [153] Chitosan (CS)/ Polycaprolactone (PCL) NFs Dermal Wound dressing [154] Collagen loaded PHB/Gelatin NFs Wound dressing [155] TGF-β1 inhibitor loaded Polycaprolactone (PCL)/ Gelatin composite NFs For Clinical Hypertrophic scars prevention [156] Chitosan (CS)/Polyvinyl alcohol (PVA) NFs Bone regeneration [157] Oxidized Starch-CS-calcium phosphate-Polycaprolactone (PCL) composite NFs Bone Tissue engineering [158] Boron Nitride/Gelatine NFs Bone Tissue engineering [159] Polycaprolactone (PCL)/ Stem cells based bone tissue [160] Gelatine composite NFs engineering 48 Gelatin/Genipin composite NFs Tympanic membrane repair [161]…”

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Application of Biopolymeric Electrospun Nanofibers in Biological Science

Shekh

2021

Materials Research Foundations

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Biopolymers are those class of macromolecules which are found in nature or extracted from the living organisms. Various structures and properties of the biopolymers-based materials are well researched till to date. These mainly includes hydrogels, bio glasses, bio inks, biocomposites, fibers and others. These biopolymers-based structures have some limitations. However, Biopolymers have some common advantages (i.e., non-toxicity, easy availability, monodispersity, degradability, and better solubility etc.) and disadvantages (i.e., poor thermal and chemical stabilities, brittleness etc.). To overcome these disadvantages, it is necessary to tailor these polymers by few emerging techniques like “Electrospinning”. Electrospinning is one of the easiest techniques to prepare nanofibers from polymeric solutions by applying high voltage. Obtained nano/micro structural polymeric fibers have good properties like high surface area, porosity and low weights etc. The materials having high surface area and porosity can easily interact with cells and tissues, are better mobile vehicles for drugs, as well as possess good filtration and adsorption abilities. Thus, these one-dimensional structures of the biopolymers are very useful in various fields of biomedical especially water sanitation/desalination, tissue engineering, drug delivery and scaffolds. Various biopolymers like chitosan, chitin, sodium alginate, guar gum, polylactic acid and others are successfully fabricated as fibers and used in various fields of biomedical.

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In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

Cited by 12 publications

References 28 publications

Investigating the Synthesis and Characterization of a Novel “Green” H2O2-Assisted, Water-Soluble Chitosan/Polyvinyl Alcohol Nanofiber for Environmental End Uses

Investigating the Synthesis and Characterization of a Novel “Green” H2O2-Assisted, Water-Soluble Chitosan/Polyvinyl Alcohol Nanofiber for Environmental End Uses

Modifying the thermomechanical properties of electrospun fibres of poly-vinyl cinnamate by photo-cross-linking

Application of Biopolymeric Electrospun Nanofibers in Biological Science

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