Antimicrobial effects of fentanyl and bupivacaine: an in vitro study

Kesi̇ci̇, Sevgi; Demırci, Mehmet; Kesici, Uğur

doi:10.1016/j.bjane.2020.04.026

Cited by 2 publications

(2 citation statements)

References 22 publications

(36 reference statements)

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“…Fentanyl is an effective bactericidal anesthetic drug against Gram-positive bacteria. This data is also supported by previous anesthetic solution and preservative studies (Dantas et al, 2000;Kesici et al, 2020). Only Ketalar showed antifungal activity against C. albicans and no other anesthetic drugs showed antifungal activity against C. albicans.…”

Section: Discussionsupporting

confidence: 85%

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Determination of Antimicrobial and Antioxidative Properties of Several Anesthetic Drugs

et al. 2023

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For various reasons, the balance between oxidative stress and the antioxidative defence system is disturbed during general anesthesia. On the other hand, thanks to their antioxidant effect, certain anesthetics have been suggested to protect from oxidative stress caused due to pathological states. In this study, potential antimicrobial and antioxidative activities of commonly used anesthetic drugs were evaluated to reveal possible effects after surgery. The antimicrobial activities of commercially purchased anesthetic drugs diluted with sterile physiological saline were investigated according to the Kirby-Bauer disc diffusion method. Furthermore, minimum inhibitory concentration and minimum bactericidal concentrations were determined. Antioxidative potentials of the drugs were screened according to 2,2 diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH●) radical scavenging assays. One of the tested drugs, Ketalar, containing ketamine hydrochloride was found to have an inhibition effect on all tested pathogenic microorganisms. At the same time, Mivacron and Pental Sodium formed the most significant inhibition zones on Micrococcus luteus. As expected, Propofol had no antimicrobial activity on most tested organisms. However, its antioxidant activity was the highest among the other drugs. Calculated SC50 values for DPPH-free and hydroxyl radical scavenging activities of Ultiva, Blok-L, and Zolamid were very close to Propofol. It can be concluded that using these drugs for anesthesia may suppress the risk of contamination and oxidative stress that may occur during use in many cases.

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Section: Discussionsupporting

confidence: 85%

“…Fentanyl is used as a part of anesthesia to avoid pain after surgery or for other medical procedures (Kesici et al, 2020). Fentanyl, which has come to the fore with the death of the famous singer Prince in recent years, is a member of the powerful painkiller drug group called opioids.…”

Section: Thismentioning

confidence: 99%