Antimicrobial Effect of Imipenem-Functionalized Fe2O3 Nanoparticles on Pseudomonas aeruginosa Producing Metallo b-lactamases

Khataminejad, Mohammad Reza; Mirnejad, Reza; Sharif, Malike; Hashemi, Mojtaba; Sajadi, Nikita; Piranfar, Vahhab

doi:10.15171/ijb.1138

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…Moreover, these particles may occupy the active site of MBLs, blocking their action. By impairing the antibiotic resistance mechanisms of bacteria, resistant strains became more susceptible to carbapenems [ 162 ].…”

Section: Nanosystems As Antimicrobial Treatments Of Infectionsmentioning

confidence: 99%

Nanobiosystems for Antimicrobial Drug-Resistant Infections

et al. 2021

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The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems. Additionally, the use of bacteriophages alone or in combination with drugs has been recently revisited; some studies utilizing nanosystems for bacteriophage delivery have been already reported. In this review article, we focus on nine pathogens that are the leading antimicrobial drug-resistant organisms, causing difficult-to-treat infections. For each organism, the bacteriophages and nanosystems developed or used in the last 20 years as potential treatments of pathogen-related infections are discussed. Summarizing conclusions and future perspectives related with the potential of such nano-antimicrobials for the treatment of persistent infections are finally highlighted.

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Section: Nanosystems As Antimicrobial Treatments Of Infectionsmentioning

confidence: 99%

Nanobiosystems for Antimicrobial Drug-Resistant Infections

et al. 2021

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“…Fe2O3 NPS: Iron Oxide Nanoparticles Option It is good for inhibiting the growth of P. aeruginosa [72]. The effect of Fe2O3 nanoparticles with the action of imipenem antibiotic on Metallo-β-Lactamase (MBL) P. aeruginosa with a predefined concentration of nanoparticles increases the effects of imipenem against resistant bacteria [73].…”

Section: Cao Npsmentioning

confidence: 99%

Untitled

Ghandali

Mirnurollahi²,

Safarkar

2021

Asian J. Nanosci. Mater.

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The purpose of this research study was to assess the use of nanoparticles in combat pathogenic microorganisms and also to investigate the synergistic effect of nanoparticles with antibiotics in eliminating these factors. In this work, the influence of different nanoparticles on microorganisms was evaluated in 89 studies. It was found that nanoparticles can be used against microorganisms, either independently or by their synergistic effect with antibiotics. The study found that metal nanoparticles have a more antimicrobial effect, among metal nanoparticles, silver nanoparticles exert the most specific among all microorganisms. Meanwhile, metal nanoparticles can be a good alternative to the use of antibiotics and inhibitors of pathogens.

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“…In order to determine the presence of the beta lactamase gene, the primers (′5-CGGCCGTCAG GAGACGGTCT TT-3′ and ′5-AACCAGTTTTGCCTTTACCTAT-3′) were prepared using the software Primer-BLAST [3]. PCR was performed in a 50 µl mixture reaction containing PCR buffer (5 µl of 10×), MgCl 2 (1.5 mM), dNTPs (0.2 mM), Taq DNA polymerase (1.0 U), 2 µl of each primer (10 pm µl −1 ) and 1 µl of DNA template.…”

Section: Pcr Amplificationmentioning

confidence: 99%

“…Today, microbial resistance to antibiotics in health care centers is a serious problem, affecting initial and simple methods of treatment. Therefore, the use of new treatments and compounds for the treatment of hospital infections is inevitable [3].…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial activity of imipenem immobilized on surface of spherical and rod gold nanoparticles

Amini¹,

Kamali²,

Amini³

et al. 2018

J. Phys. D: Appl. Phys.

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Pseudomonas aeruginosa is an opportunistic pathogen that has a high resistance to antibiotics and can cause disease in patients with immune deficiency. Therefore, in the present study, the antimicrobial effects of imipenem-functionalized spherical and rod gold nanoparticles (SGNPs and RGNPs) have been investigated on P. aeruginosa. Firstly, SGNPs and RGNPs were synthesized by citrate reduction and seed-growth methods, respectively. The SGNPs and RGNPs were conjugated with imipenem (Imp-SGNPs and Imp-RGNPs). The size, potential and morphology of the SGNPs and RGNPs were determined by different techniques including; TEM, DLS and UV-vis spectra. Different concentrations of Imp-SGNPs and Imp-RGNPs were used to determine the bacterial growth rate and minimum inhibitory concentration (MIC) by UV-vis spectrophotometry according to CLSI standard protocol. The results indicated that the drug loading on the surface of SGNPs and RGNPs was 60.5% and 54%, respectively. The Imp-SGNPs and Imp-RGNPs exhibited greater antibacterial activity compared to that of imipenem alone. The highest antibacterial activity of GNPs was observed in the Imp-RGNPs against P. aeruginosa. The MIC for 90% inhibition (MIC90) for imipenem, Imp-SGNPs and Imp-RGNPs was determined to be 43 µg ml −1 , 21 µg ml −1 and 5.7 µg ml −1 , respectively. These results indicated that the new nano-carrier systems with GNPs have great potential for enhanced antibacterial activities.

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Antimicrobial Effect of Imipenem-Functionalized Fe2O3 Nanoparticles on Pseudomonas aeruginosa Producing Metallo b-lactamases

Cited by 10 publications

References 11 publications

Nanobiosystems for Antimicrobial Drug-Resistant Infections

Nanobiosystems for Antimicrobial Drug-Resistant Infections

Untitled

Enhanced antibacterial activity of imipenem immobilized on surface of spherical and rod gold nanoparticles

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