Antimicrobial Effect of Garlic (Allium sativum) and Traditional Medicine

Goncagül, Gülşen; Ayaz, Erol

doi:10.3923/javaa.2010.1.4

Cited by 45 publications

(29 citation statements)

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“…However, these results could be explained on the basis that garlic contains a wide range of the thiosulfinates that have antibacterial activity (Iimuro et al 2002). This antibacterial activity is related to inhibition of enzymes including thiol, which occurs in microorganisms Goncaqul and Ayza (2010). Moreover, Allicin in the garlic acts by totally inhibiting RNA synthesis and partially inhibiting DNA and protein synthesis of the parasites (Feldberg et al 1988).…”

Section: Discussionmentioning

confidence: 99%

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

et al. 2015

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Controversy surrounding the pathogenic role of Blastocystis spp. in humans and lack of well-established diagnostic criteria led to debates concerning the treatment for that organism. Furthermore, some strains develop resistance against the recommended drugs. Thus, using natural medicine has many positive aspects to address these points. In an earlier study, we addressed in vitro effect of garlic and ginger on Blastocystis spp. isolates as an alternative treatment. Accordingly, this study was conducted to evaluate in vivo activities of these two herbs on mice infected with Blastocystis spp. Antiprotozoan activities were determined by monitoring Blastocystis shedding in stools and histopathological changes of the intestine of infected mice. Additionally, assessment of the antioxidant effect (via measuring the level of malondialdehyde (MDA) production) of these herbs on the treated groups of mice was done. Also, their effects on nitric oxide (NO) production were assessed. In this work, treatment of infected mice with garlic, ginger, and nitazoxanide (NTZ) reduced the shedding of cysts significantly compared to the infected untreated group, P value ≤0.001, 0.0001, and 0.0003, respectively. As well, histopathological examination revealed that Blastocystis was frequently observed within the lumen, at the tip of the epithelium, and/ or infiltrated in an enterocyte in the infected group without treatment compared to that of the infected treated ones. Furthermore, mice infected with Blastocystis exhibited increased levels of NO (440.09 ± 3.7 vs. 276.66 ± 0.8, P ≤ 0.001) and MDA production (106.19 ± 0.43 vs. 63.06 ± 0.45, P ≤ 0.0004) compared to that of the uninfected controls. Treatment of infected mice with garlic, ginger, and NTZ reduced NO levels to 54.41 ± 1.2, 47.70 ± 1.2, and 37.43 ± 0.98 and MDA levels to 22.38 ± 0.17, 63.34 ± 3.89, and 66.76 ± 9.1, respectively. We conclude that using ginger and garlic for treatment of blastocystosis is beneficial.

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Section: Discussionmentioning

confidence: 99%

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

et al. 2015

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“…Garlic leaves can be consumed fresh or lyophilized and used in the food industry as an additive to meat and milk products. Garlic is one of the most versatile plant materials, with strong bactericidal and fungicidal, anti-atherosclerotic and general strengthening effects [1]. Its most important active component is an essential oil, whose main ingredients are allyl sulfides, phenolic acids, and L-ascorbic acid [2,3].…”

Section: Introductionmentioning

confidence: 99%

Influence of Catch Crops on Yield and Chemical Composition of Winter Garlic Grown for Bunch Harvesting

et al. 2020

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The cultivation of catch crops left on the surface of the field in the form of mulch promotes sustainable farming practices, while protecting the biodiversity of agricultural landscape. The paper presents results of research from 2013–2016, aimed at determining the usefulness of catch crops of millet, buckwheat, white mustard, bird’s-foot and Egyptian clover for soil mulching in winter garlic cultivation. The effect of soil litter on the amount of garlic crop in cultivation for bunch harvest and nutritional value determined by chemical composition of edible parts was determined. In the edible part of garlic, the content of dry matter, total and reducing sugars, L-ascorbic acid, total ash, crude fiber, phenolic acids and essential oil was evaluated. The control consisted of plots without mulch plants. In the cultivation of garlic under organic mulch, there was no decrease in commercial yield and no negative competitive effect on yielding. Garlic plants cultivated with mulch plants were characterized by increased height and developed more leaves. The catch crops used in the form of mulch did not affect the dry matter and total ash content in garlic bulbs. In the cultivation with plant litter, the concentration of phenolic acids and essential oil in the leaves was higher and the content of crude fiber was lower, compared to the cultivation without litter. Biomass from catch crops from clover and mustard increased the content of L-ascorbic acid, at the same time reducing the content of total and reducing sugars in the edible part of garlic, except for mulch plants of the bean family. The chemical composition of garlic was affected by different thermal and precipitation conditions in the years of research. In 2016, the year with the highest total rainfall, plants accumulated more dry matter, L-ascorbic acid as well as total and reducing sugars than in 2014 and 2015, years with less rainfall. Our research indicates that there are prospects for practical application of catch crops in the form of mulch for garlic cultivation to enhance the level of nutrients, without compromising the yield.

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“…The difference in activity against these two types of bacteria is attributed to the difference of structure of cell membrane. Gram positive bacteria have thicker peptidoglycan cell membranes compared to the Gram negative bacteria, hence, it is harder for CuNPs to penetrate it resulting lower ZOI [18]. These recorded (ZOI) values of corresponding bacteria seemed to be lower than that of standard antibiotic Ofloxacin, (positive control) may be due to weak solution of Copper nanoparticle.…”

Section: Antibacterial Activity Of Copper Nanoparticlesmentioning

confidence: 99%

“…The medicinal values of garlic has been attributed due to presence of many significant phytochemicals such as allicin, allinin, ajoene, diallylsulfide, enzymes, B-vitamins, proteins, minerals, saponins, and flavonoids etc. [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Bio-Synthesis of copper nanoparticles (CuNPs) using Garlic extract to investigate antibacterial activity

Amatya

Joshi

2020

BIBECHANA

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Bio-synthesis of metal nanoparticles (CuNPs) is regarded as one of the recently developed, economic and environmentally benign method. In the present investigation, Copper nanoparticles were synthesized reacting garlic (Allium sativum) extract with Copper Sulphate (CuSO4∙5H2O) solution over magnetic stirrer at 80 °C for 1 hour. So-prepared CuNPs were studied by observing the color change at various time intervals. Further, the nanoparticles were characterized using UV-Visible spectroscopy, Energy Dispersive X-ray spectroscopy (EDX) and Fourier Transform Infrared spectroscopy (FTIR). The results of UV-Vis spectroscopy clearly showed presence of absorption peak at 595 nm which confirmed the formation of copper nanoparticles. Likewise, the EDX spectrum depicts the presence of optical band at 8 eV which is the characteristic peak of Copper consisting of 38.747 % by weight and FTIR spectra revealed presence of various phytochemicals possessing characteristic functional groups such as carbonyl and phenolic at the surface of CuNPs. Thus, natural products available in the garlic extract help in reduction and stabilization of Copper nanoparticles. The antibacterial activity of Copper nanoparticles was investigated against Gram +ve (Staphylococcus aureus) and Gram –ve bacteria (Escherichia coli) using Agarwell diffusion method. The results of antibacterial test showed that CuNPs were found to be much sensitive towards Gram –ve bacteria compared to gram +ve bacteria. BIBECHANA 17 (2020) 12-18

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Antimicrobial Effect of Garlic (Allium sativum) and Traditional Medicine

Cited by 45 publications

References 1 publication

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

Influence of Catch Crops on Yield and Chemical Composition of Winter Garlic Grown for Bunch Harvesting

Bio-Synthesis of copper nanoparticles (CuNPs) using Garlic extract to investigate antibacterial activity

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