Antimicrobial effect of 4-hydroxybenzoic acid ester with glycerol

Kosová, M.; Hrádková, Iveta; Matlova, Veronika; Kadlec, D.; Šmidrkal, Ján; Filip, V.

doi:10.1111/jcpt.12285

Cited by 24 publications

(21 citation statements)

References 19 publications

(35 reference statements)

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“…; Kosová et al . ). Increased expression of both hypoxanthine and tricarballylate in LP+RBE suggested that RBE modulations to L. paracasei nucleotide and TCA cycle metabolism are important to its S .…”

Section: Discussionmentioning

confidence: 97%

Lactobacillus paracaseimetabolism of rice bran reveals metabolome associated withSalmonellaTyphimurium growth reduction

2017

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AimsThis study aimed to determine the effect of a cell‐free supernatant of Lactobacillus paracasei ATCC 27092 with and without rice bran extract (RBE) on Salmonella Typhimurium 14028s growth, and to identify a metabolite profile with antimicrobial functions.Methods and ResultsSupernatant was collected from overnight cultures of L. paracasei incubated in the presence (LP+RBE) or absence (LP) of RBE and applied to S. Typhimurium. LP+RBE reduced 13·1% more S. Typhimurium growth than LP after 16 h (P < 0·05). Metabolite profiles of LP and LP+RBE were examined using nontargeted global metabolomics consisting of ultra‐high‐performance liquid chromatography coupled with tandem mass spectrometry. A comparison of LP and LP+RBE revealed 84 statistically significant metabolites (P < 0·05), where 20 were classified with antimicrobial functions.Conclusions LP+RBE reduced S. Typhimurium growth to a greater extent than LP, and the metabolite profile distinctions suggested that RBE favourably modulates the metabolism of L. paracasei. These findings warrant continued investigation of probiotic and RBE antimicrobial activities across microenvironments and matrices where S. Typhimurium exposure is problematic.Significance and Impact of the StudyThis study showed a novel metabolite profile of probiotic L. paracasei and prebiotic rice bran that increased antimicrobial activity against S. Typhimurium.

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Section: Discussionmentioning

confidence: 97%

Lactobacillus paracaseimetabolism of rice bran reveals metabolome associated withSalmonellaTyphimurium growth reduction

2017

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“…Other metabolites from this study that varied by cultivar, and that should be considered for importance to human health, were 4-hydroxybenzoate and salicylate. The 4-hydroxybenzoate had a higher relative abundance in Rang Jay (grown in Cambodia), and this compound has established antimicrobial properties [62,74], as well as antioxidant [75] actions. Salicylate, a phytochemical with a broad function in plant growth and development [76], is also an active component of aspirin, and it has well-documented anti-diabetic, anti-inflammatory, and cardio-protective properties [77,78].…”

Section: Discussionmentioning

confidence: 99%

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene–Bran Metabolite Relationships

et al. 2018

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Rice (Oryza sativa L.) processing yields ~60 million metric tons of bran annually. Rice genes producing bran metabolites of nutritional and human health importance were assessed across 17 diverse cultivars from seven countries using non-targeted metabolomics, and resulted in 378–430 metabolites. Gambiaka cultivar had the highest number and Njavara had the lowest number of metabolites. The 71 rice bran compounds of significant variation by cultivar included 21 amino acids, seven carbohydrates, two metabolites from cofactors and vitamins, 33 lipids, six nucleotides, and two secondary metabolites. Tryptophan, α-ketoglutarate, γ-tocopherol/β-tocopherol, and γ-tocotrienol are examples of bran metabolites with extensive cultivar variation and genetic information. Thirty-four rice bran components that varied between cultivars linked to 535 putative biosynthetic genes using to the OryzaCyc 4.0, Plant Metabolic Network database. Rice genes responsible for bran composition with animal and human health importance is available for rice breeding programs to utilize in crop improvement.

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“…Other metabolites from this study that varied by cultivar and should be considered for importance to human health were 4-hydroxybenzoate and salicylate. The 4-hydroxybenzoate had a higher relative abundance in Rang Jay (grown in Cambodia), and this compound has established antimicrobial properties [62,74] as well as antioxidant [75] actions. Salicylate, a phytochemical with a broad function in plant growth and development [76], is also an active component of aspirin and has well-documented anti-diabetic, anti-inflammatory, and cardio-protective properties [77,78].…”

Section: Discussionmentioning

confidence: 99%

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene-Bran Metabolite Relationships

Zarei¹,

Luna²,

Leach³

et al. 2018

Preprint

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Rice (Oryza sativa L.) processing yields ~60 million metric tons of bran annually. Rice genes producing bran metabolites of nutritional and human health importance were assessed across 17 diverse cultivars from seven countries using non-targeted metabolomics and resulted in 378-430 metabolites. Gambiaka cultivar had the highest number and Njavara had the lowest number of metabolites. The 71 rice bran compounds of significant variation by cultivar included 21 amino acids, seven carbohydrates, two metabolites from cofactors and vitamins, 33 lipids, six nucleotides, and two secondary metabolites. Tryptophan, -ketoglutarate, γ-tocopherol/β-tocopherol and γ-tocotrienol are example bran metabolites with extensive cultivar variation and genetic information. 34 rice bran components that varied between cultivars linked to 535 putative biosynthetic genes using to the OryzaCyc 4.0, Plant Metabolic Network database. Rice genes responsible for bran composition with animal and human health importance is available for rice breeding programs to utilize in crop improvement.

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Antimicrobial effect of 4-hydroxybenzoic acid ester with glycerol

Cited by 24 publications

References 19 publications

Lactobacillus paracaseimetabolism of rice bran reveals metabolome associated withSalmonellaTyphimurium growth reduction

Lactobacillus paracaseimetabolism of rice bran reveals metabolome associated withSalmonellaTyphimurium growth reduction

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene–Bran Metabolite Relationships

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene-Bran Metabolite Relationships

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