Antimicrobial Compounds from Leaf Extracts ofJatropha curcas,Psidium guajava, andAndrographis paniculata

Rahman, Md. Shahedur; Ahmad, Siti Hajar; Mohamed, Mahmud Tengku Muda

doi:10.1155/2014/635240

Cited by 81 publications

(50 citation statements)

References 23 publications

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“…The same compound was reported in related species Jatropha curcas 37 and other plant species such as Iris germanica 38 , Rorippa indica 39 and Indigofera suffruticosa 40 . This compound was reported to possess antioxidant, nematicidal, pesticidal and anti-androgenic properties 39 .…”

Section: Gc-ms Analysissupporting

confidence: 76%

Untitled

2016

IJPSR

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Since, the free radicals induced oxidative stress is posing threat present researchers are focusing on natural sources that could serve as antioxidants to combat the oxidative damage mediated diseases such as diabetes, atherosclerosis and cancer. In this context, present study was carried out to investigate the botanical characters, chemical composition and in vitro antioxidant potential of Jatropha gossypifolia L. so as to provide scientific evidences for the medicinal properties claimed on this plant. Microscopic studies were conducted on both entire leaf and leaf powder, the elemental composition of leaf powder was investigated. Extracts of J. gossypifolia leaf was prepared with hexane, chloroform, ethyl acetate, ethanol and water and screened for the detection of various phytochemicals and the major phytochemical compounds present were identified through HPTLC and GC-MS analysis. In vitro antioxidant activity of solvent extracts was evaluated through reducing power and DPPH radical scavenging assays. Phytochemical screening revealed the presence of phenols, flavones, glycosides, steroids, alkaloids and quinines in the ethanolic extract. Quantification of phytochemicals showed 3.35 mg/kg of alkaloids, 3.60 mg/kg flavonoids, 0.22 mg/kg tannins and 0.12 mg/kg glycosides. Elemental composition revealed the existence of high level of calcium (3.89%) and iron (85 ppm), which have clinical importance. Presence of alkaloids, quercetin, and fraxetin were confirmed with HPTLC analysis. Among the different solvent extracts, ethyl acetate exhibited higher antioxidant activity. Presence of phytochemicals such as p-Cymene, Fumaric acid, 12-Octadecanoic acid, 1-Heptadecanol, and Yashabushiketol were confirmed in this plant through GC-MS analysis. Botanical and chemical standards were determined for J. gossypifolia leaf through the present investigation and the results of in vitro antioxidant assays gives the scientific evidence for the health benefits and medicinal effects claimed on J. gossypifolia.

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Section: Gc-ms Analysissupporting

confidence: 76%

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2016

IJPSR

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“…Octadecanoic acid from Azadirachta indica (neem) extracts [30] and marine red seaweeds, namely, Jania rubens, Corallina mediterranea and P. capillacea exhibited antibacterial activity against Staphylococcus aureus, Escherichia coli and Salmonella spp [26]. Previous report showed that 9,12-octadecadienoic acid (Z,Z)-, methyl ester from chloroform extract of Albizia adianthifolia (Schumach) [31,32] and methanol extract of Jatropha curcas [33], which is a closely related compound to 12,15-octadecadienioc acid, methyl ester present in AqEUF of C. papaya, impeded cell proliferation and microbial growth.…”

Section: Discussionmentioning

confidence: 99%

GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

Ezekwe¹,

Chikezie²

2017

J Nutr Food Sci

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The present study was aimed to identify the likely phytocomponents present in Aqueous Extract of Unripe Fruit (AqEUF) of Carica papaya. The phytocomponents present in AqEUF of C. papaya was identified using GC-MS detection system. The results showed the presence of fifteen phytocomponents in AqEUF of C. papaya. The major phytocomponents present in AqEUF of C. papaya in terms of their relative abundance were octadecanoic acid, hexadecenoic acid, Z-11 and hexadecanoic acid, methyl ester, which corresponded to 23.84%, 19.17% and 18.25% respectively. The relative abundance of minor phytocomponents present in AqEUF of C. papaya was within a narrow range of 0.78-5.38%. The present investigation revealed that AqEUF of C. papaya was composed of variety of metabolites and therapeutic active substances as well as novel substances. These substances could be isolated and further empirically evaluated to confirm their biologic and medicinal activities as well as investigate their mechanism of action.

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“…The leaves of P. guajava contain substantial quantity of lectin, which is why the leaf extract is used as herbal remedies for intestinal infections caused by pathogens like Escherichia coli [9,10]. Previous reports also showed that mature leaf extracts of P. guajava exhibited antimicrobial properties due to their substantial content of flavonoids, namely quercetin-3-O-α-L-arabinofuranoside, quercetin-3-O-β-D-arabinofuranoside, quercetin-3-O-β-D-glucoside, quercetin-3-O-β-D-galactoside, and quercetin-3-O-β-D-arabinofuranoside [11] along with the presence of squalene and azulene, which are antifungals [12]. The diverse medicinal usefulness of decoctions of guava leaves has been extensively reported elsewhere [11,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 94%

Phytocomponents from Anacardium occidentale, Psidium guajava, and Terminalia catappa altered membrane osmotic stability of sickle erythrocytes

Chikezie

Ekeanyanwu

Chile-Agada

2020

Beni-Suef Univ J Basic Appl Sci

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Background: The present study identified, quantified, and characterized the combinations of phytocomponents from fractionated leaf extracts of Anacardium occidentale, Psidium guajava, and Terminalia catappa that stabilized sickle erythrocyte membrane against osmotic stress, or otherwise, using standard chromatographicspectrophotometric techniques, namely GC-MS, FT-IR, and UV-visible systems. Results: The percentage hemolysis of the control sample, in 0.9 g/100 mL NaCl, was 35.08 ± 11.64%, whereas those of the samples containing 40 mg/100 mL, 60 mg/100 mL, and 80 mg/100 mL of ethylacetate extracts of T. catappa ranged between 31.82 ± 8.32 and 39.18 ± 6.94%. Ethylacetate extract of T. catappa contained comparative high quantities of hexadecanoic acid methyl ester, 9,11-octadecadienoic acid, methyl ester, (E, E)-, trans-13-octadecenoic acid methyl ester, and methyl stearate. FT-IR and UV-visible spectra showed that ethylacetate extract of T. catappa contained aromatic compounds as well as nitro-compounds, phenolics, and esters. Conclusion: To mention but a few, the combinations of major phytocomponents that stabilized sickle erythrocyte membrane against osmotic stress were hexadecanoic acid, methyl ester, 11-octadecenoic acid, methyl ester, dibutyl phthalate, pentacosane, trans-13-octadecenoic acid, methyl ester, whereas the minor phytocomponents include methyl tetradecanoate, methoxyacetic acid, 3-pentadecyl ester, methyl stearate, hexadecanoic acid, isoxazole, 4,5-dimethyl-.

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Antimicrobial Compounds from Leaf Extracts ofJatropha curcas,Psidium guajava, andAndrographis paniculata

Cited by 81 publications

References 23 publications

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GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

Phytocomponents from Anacardium occidentale, Psidium guajava, and Terminalia catappa altered membrane osmotic stability of sickle erythrocytes

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