Antimicrobial, antioxidant and calcium channel blocking activities of &lt;i&gt;Amberboa divaricata&lt;/i&gt;

Iqbal, Shahid; Mushtaq, Aamir; Jabeen, Qaiser

doi:10.3329/bjp.v9i1.16989

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…Acute toxicity studies by oral administration Acute toxicity study of the crude extract of ripe and dry fruit of A. marmelos was performed according to the method described previously 15 with some modifications. Swiss albino mice of either sex were randomly divided into six groups (Group 1 to Group 6) comprised of five animals each.…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Taqvi

Versiani

Imran

et al. 2018

Bangladesh J Med Sci

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Objective: To investigate and determine the antidiarrhoeal and spasmolytic potential of fruit of Aegle marmelos is due to CCBs compounds and not tannic acid. Materials and methods: The extract of ripe and dry fruit of A. marmelos (Am.Cr) was prepared in methanol: water (70:30). The antidiarrhoeal activities of the extract, loperamide and tannic acid were studied in vivo; in castor oil induced diarrhoeal model in mice whereas spasmolytic effect was studied in vitro; in isolated mice ileum. Calcium channel blocking (CCB) activity was investigated after preincubation of mice ileum by Am. Cr or loperamide and subsequent adding of K + 80 mM. Results: Am. Cr inhibited castor oil-induced diarrhoea: onset of diarrhoea, total no. of faeces, and total no. of wet faeces dose-dependently, the dose of 800 mg/mL was found statistically significant, total weight of feces and total weight of wet faeces were also inhibited. Concentration-dependent inhibition of spontaneous contraction and contractile effect of K + 80 mM after pre-incubation by Am. Cr were confirmed in isolated mice ileum. The results of Am. Cr are comparable with Loperamide. Tannic acid produced neither antidiarrhoeal effect nor exhibited CCB activity, however relaxant effect was observed in isolated mice ileum. Conclusion: The antidiarrhoeal and spasmolytic effects of Am.Cr may be mediated through compounds which posses CCB effect. Tannic acid exhibited relaxant effect only which is not sufficient evidence scientifically to classify as antidiarrhoeal.

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Section: In Vivo Experimentsmentioning

confidence: 99%

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Taqvi

Versiani

Imran

et al. 2018

Bangladesh J Med Sci

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“…Acute toxicity test on the extract was carried out by following method described previously with little modifications. Rats were observed for mortality and general behaviours like excitation, aggressiveness, sedation, skin colour, itching and piloerection for 24 hours in tested animals provided with normal diet and tap water (Iqbal et al, 2014).…”

Section: Acute Toxicity Testingmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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Antihypertensive studies on aqueous-methanolic extract prepared from seeds of Cydonia oblonga M. were carried out. The test extract in 200, 400 and 600 mg/kg doses was investigated in normotensive, high cholesterol and glucose fed hypertensive rats through non-invasive blood pressure measuring technique. Acute and sub-chronic toxicity studies were conducted in mice and rats, respectively. The test extract significantly decreased dose dependently the systolic, diastolic and mean arterial pressures. The test extract in 600mg/kg dose produced maximum effect and prevented rise in blood pressure of high cholesterol diet and glucose fed rats as compare to control in 21 days studies. The extract was found safe up to 4g/kg dose in mice. In sub-chronic toxicity study, no significant alteration in blood chemistry of extract treated rats was observed except reduction in the low density cholesterol levels. It is concluded that Cydonia oblonga seeds extract possess antihypertensive effect which supports its use in folklore.

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“…Acute toxicity test: Acute toxicity was performed as previously described with some modifications (Iqbal et al, 2014). Mice of either sex were randomly divided into five groups of 2 animals each.…”

Section: Determination Of Antihypertensive Activity In Glucose-inducementioning

confidence: 99%

Blood pressure lowering effect of Pennisetum glaucum in rats

Mushtaq

Akhtar

Alamgeer

2015

Bangladesh J Pharmacol

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The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and glucose-induced hypertensive rats using non-invasive technique. The extract significantly (p˂0.5 - p˂0.001) decreased blood pressure and heart rate with maximum effect at 1,000 mg/kg dose. The extract was found to prevent rise in blood pressure of egg and glucose fed rats as compared to control group in 21 days study. The extract was safe in mice up to dose of 4 g/kg and sub-chronic toxicity study showed that there was no significant alterations in blood chemistry of extract treated rats. It is conceivable, therefore, that aqueous-methanolic extract of P. glaucum seeds has exerted considerable antihypertensive activity which may be due to the presence of phytochemical constituents.

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Antimicrobial, antioxidant and calcium channel blocking activities of <i>Amberboa divaricata</i>

Cited by 11 publications

References 22 publications

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

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Blood pressure lowering effect of <i>Pennisetum glaucum</i> in rats

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