Blood pressure lowering effect of &lt;i&gt;Pennisetum glaucum&lt;/i&gt; in rats

Mushtaq, Muhammad Naveed; Akhtar, Muhammad Shoaib; Alamgeer, -

doi:10.3329/bjp.v10i3.23093

Cited by 7 publications

(9 citation statements)

References 6 publications

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“…Antihypertensive studies in animals administered with FEs have not yet been conducted. Thus, the experimental dosage was selected by citing a similar previous study in which 250 and 500 mg/kg of pearl millet extracts were administered to rats to evaluate the blood-pressure-lowering effect [ 16 ]. All experimental animals received their respective treatments via oral administration of samples dissolved with 0.5% carboxymethyl cellulose (Sigma-Aldrich, St. Louis, MO, USA) for 8 weeks.…”

Section: Methodsmentioning

confidence: 99%

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

et al. 2021

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Finger millet (Eleusine coracana) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study groups were assigned as follows: (1) Wistar Kyoto rats (normal); (2) SHRs treated with saline (negative control); (3) SHRs treated with captopril 50 mg/kg bw (positive control); (4) SHRs treated with FE 250 mg/kg bw (FE250); and (5) SHRs treated with FE 500 mg/kg bw (FE500). FE supplementation improved the lipid profiles, including the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, without deterioration in liver function. The thiobarbituric acid reactive substance concentration and superoxide dismutase activity significantly improved after the application of FE250 and FE500. Interestingly, FE250 and FE500 application dramatically reduced the systolic blood pressure. FE supplementation exhibited powerful control over the renin-angiotensin system by reducing the angiotensin-converting enzyme levels and renin mRNA expression in the kidney. Additionally, FE500 application ameliorated vascular remodeling, reversed the thickening media, and decreased the media thickness/lumen diameter ratio of the aorta. These results imply that FEs are a potent antihypertensive nutraceutical for regulating the renin–angiotensin system and simultaneously inhibiting oxidative stress.

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Section: Methodsmentioning

confidence: 99%

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

et al. 2021

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“…e aqueous methanol extract of Citrus aurantifolia (AMECA) was airdried to get a honey-brown semisolid mass soluble in distilled water. e extract was preserved in an airtight container at 4 °C [5,23].…”

Section: Plant Materials and Preparation Of The Extractmentioning

confidence: 99%

“…Synthetic medicines are one of the good sources of drugs in modern medicine, are expensive, and have several side e ects [4]. erefore, di erent options of the treatment are need of the time [5]. Natural products have played a vital role in drug development for cancer, infectious diseases, multiple sclerosis, and cardiovascular diseases [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive and Vasorelaxant Effects of Citrus aurantifolia Linn. Fruit: Proposed Mechanisms

Bukhari

Alamgeer

Saeed

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Citrus aurantifolia Linn. fruit, a natural dietary item, has long been used traditionally to treat hypertension in Pakistan. The current research work aims to explore the effect on blood pressure and its mechanisms. Methods. The aqueous methanol extract of plant fruit was used to evaluate hypotensive/antihypertensive, vasorelaxation, and safety profiles. Moreover, the in vitro inhibitory effect of AMECA on phosphodiesterase was also evaluated. Results. In hypotensive studies, extracts of Citrus aurantifolia fruit exhibited a concentration-dependent reduction in SBP, DBP, MAP, and heart rate. A similar effect has been observed on anesthetized rats, but the effects exerted by the extract were not altered significantly in the presence of L-NAME, atropine, captopril, and propranolol. Moreover, in coronary arteries, the extract significantly potentiated relaxations induced by cGMP- and cAMP-dependent relaxing agonists. When exposed to PDEs, the extract concentration dependently subdued cGMP-hydrolyzing activity of different PDEs with IC50 values of 40–130 μg/mL. Conclusion. It is conceivable that extracts obtained from Citrus aurantifolia fruit produced hypotensive and antihypertensive effects in rats. The extract elicited endothelium-independent vasorelaxation, possibly by acting directly on smooth muscles of the coronary artery and by increasing cGMP and cAMP via nonselective inhibition of vascular PDEs.

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“…Cydonia oblonga dried seeds were obtained from well known herbal market of Lahore, Pakistan and identified from Dr. Amin, a taxonomist of University of Sargodha, voucher sample (CO-205A) was preserved in herbarium of University of Sargodha. An aqueous methanolic (30:70) extract of Cydonia oblonga seeds was prepared by following previously described method of Mushtaq et al (2015).…”

Section: Plant Materialsmentioning

confidence: 99%

“…Hypotensive activity of AMECO in normotensive rats was evaluated by following our previously described method (Mushtaq et al, 2015;Alamgeer et al, 2013). Briefly, rat were assigned randomly into three groups (n = 6).…”

Section: Evaluation Of Hypotensive Activity In Normotensive Ratsmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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Antihypertensive studies on aqueous-methanolic extract prepared from seeds of Cydonia oblonga M. were carried out. The test extract in 200, 400 and 600 mg/kg doses was investigated in normotensive, high cholesterol and glucose fed hypertensive rats through non-invasive blood pressure measuring technique. Acute and sub-chronic toxicity studies were conducted in mice and rats, respectively. The test extract significantly decreased dose dependently the systolic, diastolic and mean arterial pressures. The test extract in 600mg/kg dose produced maximum effect and prevented rise in blood pressure of high cholesterol diet and glucose fed rats as compare to control in 21 days studies. The extract was found safe up to 4g/kg dose in mice. In sub-chronic toxicity study, no significant alteration in blood chemistry of extract treated rats was observed except reduction in the low density cholesterol levels. It is concluded that Cydonia oblonga seeds extract possess antihypertensive effect which supports its use in folklore.

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Blood pressure lowering effect of <i>Pennisetum glaucum</i> in rats

Cited by 7 publications

References 6 publications

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Antihypertensive and Vasorelaxant Effects of Citrus aurantifolia Linn. Fruit: Proposed Mechanisms

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