Antimicrobial, antioxidant and anticancer activities of Laurencia catarinensis , Laurencia majuscula and Padina pavonica extracts

Al‐Enazi, Nouf M.; Awaad, Amani S.; Zain, Mohamed E.; Alqasoumi, Saleh I.

doi:10.1016/j.jsps.2017.11.001

Cited by 51 publications

(30 citation statements)

References 26 publications

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“…Moreover, C. paliurus extracts showed stronger antiproliferation effects on HCT-116 (IC 50 = 0.84 mg/mL), MCF-7 (IC 50 = 1.5 mg/mL), HeLa (IC 50 = 1.4 mg/mL) and HepG2 (IC 50 = 4.1 mg/mL) cancer cells than chlorogenic acid complex isolated from green coffee beans [42]. The antiproliferation effects of the ethanol extracts from most C. paliurus populations on A-549, HCT-116, HepG2, MCF-7 cancer cells was weaker than that from the three algal species, but five C. paliurus populations showed better antiproliferation effects on HeLa cancer cell than Laurencia majuscule species [43]. In terms of antiproliferation effects on HeLa cells, C. paliurus can be compared with of Thai medicine plants [44].…”

Section: Effects Of Solvent and Geographical Origin On Anticancer Actmentioning

confidence: 89%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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Section: Effects Of Solvent and Geographical Origin On Anticancer Actmentioning

confidence: 89%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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“…In another study, ethanol extract significantly exhibiting antibacterial activity against fish pathogenic bacteria was found [ 14 ]. Ethanolic extract of brown alga, Padina pavonica having antimicrobial, antioxidant, and anticancer activities was proved [ 15 ]. Padina pavonica extract contain phenolic, flavonoid and tannin which exhibits antioxidant activity [ 16 ] whereas there is no report on Spyridia hypnoides and Centroceras clavulatum.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

et al. 2020

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In recent times, there has been a growing interest in the exploration of antioxidants and global trend toward the usage of seaweeds in the food industries. The low molecular weight up to 14 kDa sulfated polysaccharides of seaweeds (Portieria hornemannii, Spyridia hypnoides, Asparagopsis taxiformis, Centroceras clavulatum and Padina pavonica) were evaluated for in vitro antioxidant activities and cytotoxic assay using HeLa cell line and also characterized by FTIR. The high yield (7.74% alga dry wt.) of sulfated polysaccharide was observed in P. hornemannii followed by S. hypnoides (0.69%), C. clavulaum (0.55%) and A. taxiformis (0.17%). In the brown seaweed P. pavonica, the sulfated polysaccharide yield was 2.07%. High amount of sulfate was recorded in the polysaccharide of A. taxiformis followed by C. clavulaum, P. pavonica, S. hypnoides and P. hornemannii as indicative for bioactivity. The FTIR spectroscopic analysis supports the sulfated polysaccharides of S. hypnoides, C. clavulatum and A. taxiformis are similar to agar polymer whereas the spectral characteristics of P. hornemannii have similarities to carrageenan. The higher DPPH activity and reducing power were recorded in the polysaccharide of brown seaweed P. pavonica than the red seaweeds as follows: DPPH activities: S. hypnoides > A. taxiformis > C. clavulatum > P. hornimanii; Reducing power: A. taxiformis > P. hornimanii > S. hypnoides > C. clavulatum. The polysaccharide fractions contain up to 14 kDa from red seaweeds P. hornemannii and S. hypnoides followed by brown seaweed P. pavonica exhibit cytotoxic activity in HeLa cancer cell line (and are similar to structural properties of carrageenan extracted from P. hornemannii). The low molecular weight agar like polymer of S. hypnoides and alginate like brown seaweed P. pavonica showing better in vitro antioxidant activities that are capable of exhibiting cytotoxicity against HeLa cell line can be taken up further in-depth investigation for nutraceutical study.

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“…The antibacterial activity of Padina spp against pathogenic bacteria in human has also been proved by several previous researchers. Al-Enazi et al 25 revealed that the antibacterial activity of P. pavonica against Actinobacter baumannii, Escherichia coli, Klepsiealla pneumonia, Proteus mirabilis, Pseudomonas aururinosa, Basilus suptilis, Staphylococus aureus, S. epidermis, and Streptococus phygenes. Haryani et al 26 also showed the antibacterial activity of P. australis against Vibrio colera and Salmonella thypii.…”

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confidence: 99%

Nutrient Content, Active Compound and Antibacterial Activity of Padina australis against Aeromonas hydropilla

Salosso¹,

Aisiah²,

Toruan³

et al. 2020

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Macroalgae belong to thallophytes group or plant-like organisms which generally live in coastal areas. 1-3 Macroalgae known as seaweed have significant economic value since they can be utilized as vegetables, traditional medicines, organic fertilizers, and livestock fed. 1,3 Even the phytocoloid compounds extracted from macroalgae as agar, carrageenan, and alginate 3 , it can be used as raw materials of various industries, such as medicine, cosmetics, food, etc. Based on the pigment content, macroalgae are classified as green, red, and brown macroalgae. 4,5 Several studies has been revealed that green, brown and red algae contain different metabolites and have much biological activity such as antiviral, antibacterial and antifungal. 6 Padina australis is one of the brown macroalgae that possess numerous compounds that can be used for various properties, either nutrient content or active compounds. P. australis contains 1.05 ± 0.09% protein, 0.58 ± 0.01% fat, 8.78 ± 0.80% carbohydrate, 87.25 ± 0.86% water, 2.34 ± 0.16% ash 7 and minerals as calcium, magnesium, potassium, sodium, copper, zinc, iron 8 that enable to be developed as a food source and livestock fed. P. australis also contains various active compounds, such as steroid, terpenoid, flavonoid, tannin, and saponin 2,9,10 that can be used as medicinal drugs. P. australis found abundantly in Indonesia sea and distributed almost all stony coasts including East Nusa Tenggara waters. According to Salosso and Jasmanindar 11 , brown macroalgae recorded in 5 sampling sites of Kupang Bay and distributed in all locations and sampling sites are P. australis with up to 80% occurrence frequency. Nevertheless, this species has not been maximally utilized yet by the community. 10 To optimize the utilization of P. autralis collected from Kupang Bay, a study on nutrient content, active compounds, and antibacterial activity of P. australis were carried out in this paper. MATERIALS AND METHODS P. australis collection P. australis were collected at the lowest tide in Kelapa Lima coastal waters, Kupang Bay, by searching along the coast and taking all encountered P. australis. They were put into a plastic bag, cleansed, recorded the fresh weight, air-dried, and then ready for further analyses. Chemical composition analysis Chemical composition analyses of P. australis include water, ash, protein, and fat content. 12 Carbohydrate content was determined by difference as follows: 100%-(% water + % fat + % protein + % ash). Amino acid content was determined using a High-Performance Liquid Chromatography (HPLC). Mineral analyses on calcium (Ca), potassium (K), and iron (Fe) were assayed using Atomic Absorption Spectrophotometer (AAS). Phytochemical analysis of P. australis Phytochemical investigations of P. australis include alkaloid, saponin, flavonoid, tannin, terpenoid, and steroid. Alkaloid was examined using Culvenor-Fiztgerald method, saponin was analyzed using a foam test, tannin was analysed using FeCl, and terpenoid and steroid was analyzed using the Lieberman-Burchard meth...

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Antimicrobial, antioxidant and anticancer activities of Laurencia catarinensis , Laurencia majuscula and Padina pavonica extracts

Cited by 51 publications

References 26 publications

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

Nutrient Content, Active Compound and Antibacterial Activity of Padina australis against Aeromonas hydropilla

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