Antimicrobial, antimalarial and cytotoxic spermine alkaloids from Albizia schimperiana

Samoylenko, Volodymyr; Jacob, M; Khan, Samar; Tekwani, BL; Midiwo, JO; Walker, LA; Muhammad, Ismail

doi:10.1055/s-0028-1084451

Cited by 5 publications

(4 citation statements)

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“…Further studies are needed to determine the compounds responsible for the observed antiplasmodial activity. Chloroquine-sensitive strain of Although Albizia species are well documented for their strong in vitro as well as in vivo antimalarial activities (Samoylenko et al, 2009), reports on A. versicolor are lacking. Clarkson et al (2004) detected a weak antiplasmodial activity (IC50 = 38 μg/ml) in the dichloromethane root extract C. tomentosa, which is relatively low compared to the results (IC50 = 2.19 μg/ml) found in this study.…”

Section: Resultsmentioning

confidence: 99%

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela

Meyer

Kaiser

2014

Journal of Ethnopharmacology

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Abstract:Ethnopharmacological relevance: The investigated plant species are traditionally used by Venda people of South Africa, in the treatment of malaria and associated symptoms.Aim of the study: To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. Materials and methods:In vitro antiplasmodial activity and cytotoxic properties were evaluated on twenty indigenous plant species. Ground plant material was extracted in dichloromethane: 50% methanol (1:1). Antiplasmodial activity was evaluated against the chloroquine-sensitive strain of Plasmodium falciparum (NF54). The cytotoxicity of the plant extracts were assessed against mammalian L-6 rat skeletal myoblast cells. The selectivity index (SI) values were then calculated.Results: Of the 43 plant extracts evaluated, 10 exhibited pronounced antiplasmodial activity (IC 50 ≤ 5μg/ml) with good therapeutic indices (SI ≥ 10). Lipophilic plant extracts were relatively more potent than polar extracts. Tabernaemontana elegans Stapf. (Apocynaceae) and Vangueria infausta Burch. subsp. infausta (Rubiaceae) extracts displayed significant antiplasmodial activity (IC 50 < 2 μg/ml). Conclusion:Findings of this study partly support the ethnomedical use of the investigated plant species by Venda people as antimalarial remedies. The study also highlights some of the knowledge gaps that require further phytochemical studies on the specified plant species.

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Section: Resultsmentioning

confidence: 99%

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela

Meyer

Kaiser

2014

Journal of Ethnopharmacology

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“…These include the fungi Candida albicans ATCC 90028, Cryptococcus neoformans ATCC 90113, and Aspergillus fumigatus ATCC 90906 and the bacteria methicillin-resistant Staphylococcus aureus ATCC 43300 (MRS), Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 25955, and vancomycin-resistant enterococcus. Susceptibility testing was performed using a modified version of the CLSI (formerly NCCLS) methods as previously described [9, 10]. …”

Section: Methodsmentioning

confidence: 99%

Chemical and Biological Studies of <b><i>Cannabis sativa</i></b> Roots

Elhendawy

Wanas

Radwan

et al. 2018

Med Cannabis Cannabinoids

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The chemical study of Cannabis sativa roots led to the isolation and identification of 10 compounds. Their chemical structures were unambiguously established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry as friedelan-3-one (1), epifriedelanol (2), β-sitosterol (3), ergost-5-en-3-ol (4), methyl hexadecanoate (5), pentadecanoic acid (6), 10E-hexadecenoic acid (7), 4-hydroxy-3-methoxybenzaldehyde (8), β-sitosterol-β-D-glucoside (9) and p-coumaroyltyramine (10). Compounds 5–9 were reported for the first time from C. sativa roots. All the isolated compounds were tested for their antimicrobial activity. Compound 4 showed modest activity against Cryptococcus neoformans with an IC₅₀ value of 13.7 μg/mL, while compound 10 displayed potent activity against Escherichia coli with an IC₅₀ value of 0.8 μg/mL. A high-performance liquid chromatography method was developed and validated for the detection and quantification of p-coumaroyltyramine (10) in the extracts of different varieties of C. sativa roots.

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“…Susceptibility testing was performed using a modified version of the CLSI (formerly NCCLS) methods as previously described [13,14]. M. intracellulare was tested using a modified method according to the method described in the literature [15].…”

Section: In Vitro Antimicrobial Assaymentioning

confidence: 99%

Evaluation of Secondary Metabolites from the Red Sea Tunicate Polyclinum Constellatum

Radwan¹

2017

PPIJ

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Antimicrobial, antimalarial and cytotoxic spermine alkaloids from Albizia schimperiana

Cited by 5 publications

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In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Chemical and Biological Studies of <b><i>Cannabis sativa</i></b> Roots

Evaluation of Secondary Metabolites from the Red Sea Tunicate Polyclinum Constellatum

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