In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Bapela, M.J.; Meyer, Jacqueline; Kaiser, Marcel

doi:10.1016/j.jep.2014.09.017

Cited by 38 publications

(31 citation statements)

References 21 publications

(20 reference statements)

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“…tomentosa exhibited a promising in vitro antiplasmodial property [21,27]. Additionally, the methanolic extract of roots of C. tomentosa exerted a statistically significant (P<0.05) antimalarial activity against P. berghei in mice [28].…”

Section: Discussionmentioning

confidence: 98%

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Tekulu¹,

D’Alessandro²,

Parapini³

et al. 2019

Preprint

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BackgroundVarious medicinal plants are used as alternative remedies for the management of malaria, an important infectious disease responsible for around 228 million cases and 405,000 deaths worldwide in 2018. The worsening of the disease is highly associated to an emergence of drug-resistant parasites. Hence, the search of new alternative antimalarial agents from traditionally used medicinal plants is the most viable approach. The current study was aimed to evaluate the in vitro antiplasmodial property of Aloe elegans, Aloe monticola, Capparis tomentosa, Hygrophila schulli and Tephrosia gracilipes extracts.Methods Leaf latexes were collected from Aloe elegans and Aloe monticola, whereas cold maceration with 70% ethanol was used to prepare extracts from roots of Capparis tomentosa and Tephrosia gracilipes , and leaves of Hygrophila schulli . The antiplasmodial activity of the extracts against asexual and gametocyte stages was tested using parasite lactate dehydrogenase assay and luciferase assay, respectively. Cell cytotoxicity was assessed on human microvascular endothelial cells by the MTT assayResults Of the five selected medicinal plants, leaf latex of Aloe monticola showed the best activity against both asexual stages and stage V gametocytes of Plasmodium falciparum . The leaf latex of Aloe elegans and ethanolic extract of Hygrophila schulli leaves also showed antiplasmodial property against asexual stages. On the contrary, the roots of Capparis tomentosa and Tephrosa gracilipes were inactive.Conclusion Findings of this study may partly support the acclaimed traditional use of the leaves latexes of both Aloe elegans and Aloe monticola and the ethanolic extract of Hygrophila schulli leaves for the management of mild to moderate malaria.

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Section: Discussionmentioning

confidence: 98%

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Tekulu¹,

D’Alessandro²,

Parapini³

et al. 2019

Preprint

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“…Traditional uses of B. mollis as herbal medicine encouraged researchers to evaluate antibacterial [33], antifungal [34,35], antileishmanial [14,36], antioxidative [13,37], antiplasmodial [38] and cytotoxicity [14,36,38]. Some of the documented biological activities may justify some of the medicinal uses of the species or may provide insight into the therapeutic potential of B. mollis.…”

Section: Pharmacological Properties Of Bridelia Mollismentioning

confidence: 99%

“…Bapela et al [38] assessed antiplasmodial properties of dichloromethane and methane root extracts of B. mollis using the [3H] hypoxanthine incorporation assay using chloroquine sensitive (NF54) strain of Plasmodium falciparum as the test organism. Both dichloromethane and methane extracts exhibited activity with IC 50 values of 3.06 μg/mL and 28.5 μg/mL, respectively with selectivity index of 17, which was considered not to be toxic [38]. These findings corroborate the traditional use of B. mollis as traditional medicine against fever and malaria in South Africa [29].…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

“…Bridelia mollis methanol bark extract was not cytotoxic to BALB/c mouse macrophages with half maximal cytotoxic concentration (CC 50 ) value of > 200 μg/mL [36]. Bapela et al [38] assessed cytotoxicity activities of dichloromethane and methane root extracts of B. mollis against mammalian L-6 rat skeletal myoblast cells with podophyllotoxin as a control. Both dichloromethane and methane extracts demonstrated activities with IC 50 values of 51.4 μg/mL and 49.6 μg/mL, respectively with selectivity indices value of 16.8 and 24.6, respectively, which were regarded to be nontoxic to rat skeletal myoblast L6 cells [38].…”

Section: Cytotoxicity Activitymentioning

confidence: 99%

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Utilization of <i>Bridelia mollis</i> as herbal medicine, nutraceutical and functional food in southern Africa: A review

Maroyi¹

2019

Trop. J. Pharm Res

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Purpose: To evaluate the functional food, nutraceutical and ethnomedicinal properties of Bridelia mollis throughout its geographical range. Methods: Retrieval of information on the medicinal, nutraceutical and functional food properties of B. mollis was undertaken using electronic databases, including PubMed, EThOS, ScienceDirect, SCOPUS, ProQuest, SciFinder, Medline, Open-thesis, OATD and Google Scholar. Pre-electronic literature was sourced from the University library. Results: Literature search revealed that fresh or dried fruits of B. mollis can be commercially processed into new food products and beverages in southern Africa. Bridelia mollis is traditionally used as herbal medicine for cough, itching, fever, gastro-intestinal problems, malaria, piles, parasitic worms and wounds. Pharmacological studies on B. mollis indicate that the species has antibacterial, antifungal, antileishmanial, antioxidative and antiplasmodial properties. Conclusion: Detailed studies on the phytochemistry, pharmacological and toxicological properties of B. mollis are needed in order to establish the real nutraceutical potential benefits of the species that might improve human health.

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“…Biological activities of C. spicata extracts and compounds isolated from the species include acetylcholinesterase [100], antibacterial [57,58,77,101,102], antiviral [101,103], anti-inflammatory [57,58], antileishmanial [104], antiplasmodial [57,58,63,64,102,[105][106][107], antiprotozoan [102], antioxidant [100], larvicidal [108,109], molluscicidal [60,110,111], spermicidal [112], and cytotoxicity [63,64,[102][103][104] activities.…”

Section: Biological Activities Of Cussonia Spicatamentioning

confidence: 99%

Cussonia Spicata Thunb. In Tropical Africa: Phytochemistry, Pharmacology, and Medicinal Potential

Maroyi

2019

Asian J Pharm Clin Res

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Cussonia spicata is an evergreen tree widely used as herbal medicine throughout its distributional range in tropical Africa. The current study is aimed at providing a critical review of the phytochemistry, pharmacology, and evaluation of the medicinal potential of C. spicata. Documented information on the phytochemistry, pharmacology, and medicinal applications of C. spicata was collected from several online sources which included BMC, Scopus, SciFinder, Google Scholar, Science Direct, Elsevier, PubMed, and Web of Science. Additional information on the phytochemistry, pharmacology, and medicinal applications of C. spicata was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the University library. This study showed that the bark, flowers, flower stalks, fruits, leaves, roots, root bark, and stems of C. spicata are used as antifebrile and emetic and herbal medicine for fever, nausea, vomiting, gonorrhea, venereal diseases, malaria, and mental illness. Phytochemical compounds identified from the leaves, root bark, stems, and stem bark of C. spicata include alkaloids, anthocyanins, anthracene glycosides, botulin, condensed tannins, free gallic acid, gallotannins, iridoids, pentacyclic triterpenoids, saponins, steroids, tannins, flavonoids, phenolics, triterpenoids, and volatile oils. Pharmacological research revealed that C. spicata crude extracts and compounds have acetylcholinesterase, antibacterial, antiviral, anti-inflammatory, antileishmanial, antiplasmodial, antiprotozoan, antioxidant, larvicidal, molluscicidal, spermicidal, and cytotoxicity activities. Future research should focus on evaluating the phytochemical, pharmacological, and toxicological properties of C. spicata crude extracts as well as compounds isolated from the species.

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In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

Cited by 38 publications

References 21 publications

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Utilization of <i>Bridelia mollis</i> as herbal medicine, nutraceutical and functional food in southern Africa: A review

Cussonia Spicata Thunb. In Tropical Africa: Phytochemistry, Pharmacology, and Medicinal Potential

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