Antimicrobial, Anti-inflammatory, and Antioxidant Activities of the Wood of<i>Myristica fragrans</i>

Dechayont, Bhanuz; Phuaklee, Pathompong; Chunthorng-Orn, Jitpisute; Poomirat, Saovapak; Juckmeta, Thana; Phumlek, Kalyarut; Mokmued, Khwanchanok; Ouncharoen, Kulisara

doi:10.1080/10496475.2019.1676861

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…with the lowest concentration of plant extract) that showed no growth was taken as the MBC. Values were recorded as mg/ml and all experiments were performed in triplicate [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

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Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis

Dechayont

Phuaklee

Chunthorng-Orn

et al. 2021

BMC Complement Med Ther

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Background Mahanintangtong is listed in the Thailand’s National List of Essential Medicines (NLEM). It is used to treat non-specific fevers and illnesses such as pharyngitis and chickenpox. In this study, we investigated the biological activities of the different medicinal plants used in the Mahanintangtong formula. Methods The plant materials were extracted by maceration and decoction. Antimicrobial activity, assessed by disc diffusion method, the minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were compared with commercially available standard antibiotics. To elucidate the anti-inflammatory mechanisms, inhibition of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) production was tested by Griess and ELISA techniques. Antioxidant activity was measured by ABTS and DPPH scavenging assays. Results The extracts with the best antimicrobial activities were carbonized Tectona grandis showing against Streptococcus pyogenes, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The ethanol extract of Dracaena loureiroi wood exhibited the highest NO and IL-6 inhibitory activity with IC50 values of 9.42 ± 1.81 and 12.02 ± 0.30 μg/mL, respectively. The ethanol extract of Pogostemon cablin had the highest TNF-α inhibitory with IC50 values of 10.68 ± 0.02 μg/mL. In anti-free radical testing, the ethanol extract of D. loureiroi displayed high antioxidant activity by both ABTS and DPPH assays. Conclusion The ethanol extracts from carbonized T. grandis and Mahanintangtong showed good antimicrobial activity, especially against S. pyogenes, and good anti-inflammatory activity. These findings are relevant to the pathogenesis of pharyngitis and justify additional studies to see if Mahanintangtong could have clinical utility.

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“…with the lowest concentration of plant extract) that showed no growth was taken as the MBC. Values were recorded as mg/ml and all experiments were performed in triplicate [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…A stock solution of DPPH solution in absolute EtOH (6 × 10 − 5 M) was freshly prepared and protected from light [ 17 ]. The herb extracts were prepared in a serial dilution (5 concentrations).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis

Dechayont

Phuaklee

Chunthorng-Orn

et al. 2021

BMC Complement Med Ther

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“…was studied to compare the properties of its ethanolic and water extracts. The latter was found to have better antioxidant, antiinflammatory (inhibition of NO, TNF-α, and IL-6), and antimicrobial properties (especially against Streptococcus pyogenes, but also Staphylococcus aureus and Candida albicans) [Dechayont et al 2020].…”

Section: In Vitro Researchmentioning

confidence: 99%

Biologically active compounds of plant origin in medicine

Chwil¹,

Skoczylas²

2021

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“…The water and ethanolic extracts of Myristica fragrans (Myristicaceae) wood displayed interesting antimicrobial, anti-inflammatory, and antioxidant activities [ 47 ].…”

Section: Natural Extracts With Antimicrobial Activitymentioning

confidence: 99%

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

et al. 2021

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Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.

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Antimicrobial, Anti-inflammatory, and Antioxidant Activities of the Wood ofMyristica fragrans

Cited by 7 publications

References 39 publications

Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis

Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis

Biologically active compounds of plant origin in medicine

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

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