Antimicrobial and antioxidant properties of various Greek garlic genotypes

Petropoulos, Spyridon Α.; Fernandes, Ângela; Barros, Lillian; Ćirić, Ana; Soković, Marina; Ferreira, Isabel C.F.R.

doi:10.1016/j.foodchem.2017.10.078

Cited by 77 publications

(48 citation statements)

References 36 publications

(44 reference statements)

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“…The DPPH scavenging activity was 18.25 ± 0.63% when the concentration of the extract was 12.8 mg/ml. The study of Petropoulos et al (), IC 50 values of DPPH radical scavenging activities of various Greek garlic genotypes were 2.00–20.09 mg/ml. Pavlovic et al () studied different extracts (different rates of ethanol, water, and methanol) of wild garlic ( Allium ursinum ) and radical scavenging activities were 0.63–1.40 mg/ml IC 50 values.…”

Section: Resultsmentioning

confidence: 93%

“…The DPPH scavenging activity was 18.25 ± 0.63% when the concentration of the extract was 12.8 mg/ml. The study ofPetropoulos et al (2018), IC 50 values of DPPH radical scavenging activities of various Greek garlic genotypes were 2.00-20.09 mg/ml Pavlovic et al (2017). studied different extracts (different rates of ethanol, water, and methanol) of wild garlic (Allium ursinum) and radical scavenging activities were , The ethanol extract of A. macrochaetum aerial part; AMAW, The water extract of A. macrochaetum aerial part; AMBE, The ethanol extract of A. macrochaetum bulbs; AMBW, The water extract of A. macrochaetum bulbs; D, peak observed, concentration is lower than the LOQ but higher than the LOD; N.D, not detected.a RT: Retention time.…”

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confidence: 99%

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Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

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The study was aimed to investigate the phenolic compounds of Allium macrochaetum by LC‐MS/MS, as well as the antioxidant, antialzheimer, and antimicrobial activities of the extracts, and determination of the essential oil and fatty acid compositions by GC‐MS. The results indicate that malic acid and t‐caffeic acid are the major compounds in the bulbs. The main components of fatty acids were found to be linolenic (40.72%), oleic (19.79%), and palmitic (18.45%) acids. The allyl disulfide (66.97%) was found as major compound in the essential oil. The ethanol extract of the bulbs exhibited stronger ABTS cation (IC50: 55.90 ± 1.08 µg/ml) and DPPH free (IC50: 204.43 ± 2.17 µg/ml) radical scavenging activities than the other extracts. The extract also showed moderate cupric reducing activity with 1.52 absorbance at 100 µg/ml concentration. Only the ethanol extract of the bulbs showed weak inhibition (23.34 ± 0.11%) against butrylcholinesterase enzyme at 200 µg/ml. Practical applications Allium macrochaetum is a wild and edible garlic species which grown in Turkey, Iran, Iraqi, and Syria. A. macrochaetum has been used by local people in Turkish folk medicine as an antibiotic, and for the treatment of alopecia. The health benefits and nutritional values of A. macrochaetum were clarified in the first time. Phenolic compounds of A. macrochaetum were detected by LC‐MS/MS. The essential oil and fatty acid compositions of A. macrochaetum were identified by GC‐MS. Antioxidant, antialzheimer, and antimicrobial activities potential of A. macrochaetum were determined.

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Section: Resultsmentioning

confidence: 93%

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Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

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“…The existent genetic variation in garlic genotypes cultivated in Greece and its relation with the biochemical and antimicrobial properties of garlic have also been reported [12]. Fanaei et al [13] observed significant differences in garlic pungency among various genotypes, while Jabbes et al [14] reported significant differences in organosulfur compounds content among 31 Tunisian garlic landraces.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Value, Chemical Characterization and Bulb Morphology of Greek Garlic Landraces

et al. 2018

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Garlic (Allium sativum L.) is an important vegetable crop throughout the world. In Greece there are many areas which have specialized in garlic cultivation through the last decades, considered the main production areas. However, despite the significance of garlic as a food product and the high annual income of this crop, there is a decreasing trend in total cultivated area in Greece, and the local landraces are gradually neglected in favor of new imported genotypes. In the present study, garlic genotypes (local landraces/varieties, imported genotypes, commercial cultivars) from the main production regions of Greece were assessed for their chemical composition and quality (total soluble solids, dry matter content, nutritional value, mineral composition, organic acids, fatty acids content and free sugars content), and bulb morphology. The results of the present study showed significant diversity in quality features and bulb morphology, not only between the genotypes from different growing regions, but also between those of the same region. This result is interesting since it could be implemented for further improvement and valorization of this important vegetable crop through extensive breeding programs within the framework of sustainability and genetic, material conservation.

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“…Several organosulfur compounds of garlic have been shown to exert multiple pharmacological activities (32)(33)(34)(35)(36)(37)(38), and studies have demonstrated that aqueous garlic extract has antioxidant properties (39,40). It is well-known and well-published that garlic extract possessed the strong antioxidant activities in vitro and in vivo (41)(42)(43). However, there have been no further studies of the active components of garlic extract in terms of the antioxidant effect.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity and leukemia initiation prevention in�vitro and in�vivo by N‑acetyl‑L‑cysteine

et al. 2018

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-acetyl-L-cysteine (NAC) is the most abundant water-soluble component of garlic. No study to date has studied the leukemia prevention ability of NAC in mouse systemic leukemia model. The current study aimed to investigate the leukemia initiation prevention potential of NAC in a mouse model. The cytotoxic concentration of NAC was determined first in HL-60 cells, and its activity was studied in a mouse acute myelocytic leukemia model with WEHI-3 leukemia cells. The results showed that a non-toxic concentration of NAC efficiently scavenged free-radicals, lowered lipid peroxidation and reduced DNA damage induced by hydrogen peroxide in a cultured HL-60 leukemia cell line. NAC also elevated the cellular antioxidant enzyme activity significantly. Furthermore, NAC prevented mouse death induced by injection of murine WEHI-3 leukemia cells and reduced organ damage, as well as activated antioxidant mechanisms. The results of this study provided strong evidence that NAC may have potential benefits in terms of elevating antioxidant activity and preventing leukemia initiation.

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Antimicrobial and antioxidant properties of various Greek garlic genotypes

Cited by 77 publications

References 36 publications

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Nutritional Value, Chemical Characterization and Bulb Morphology of Greek Garlic Landraces

Antioxidant activity and leukemia initiation prevention in�vitro and in�vivo by N‑acetyl‑L‑cysteine

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