Antimicrobial Agents Produced by Marine Aspergillus terreus var. africanus Against Some Virulent Fish Pathogens

Barakat, Khouloud M.; Gohar, Yousry M.

doi:10.1007/s12088-012-0255-1

Cited by 17 publications

(16 citation statements)

References 32 publications

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“…africanus. [12] These reports illustrate the promising prospect of finding active compounds from marine microorganisms that act against aquatic pathogenic bacteria.…”

Section: Resultsmentioning

confidence: 96%

“…[13,14] However, the reports about the antimicrobial activity of active metabolites isolated from marinederived fungi are mainly focused on human pathogens. [15] There are only a few reports about aquatic pathogens, [12] although marine-derived fungi have been recognized as rich source of novel and biologically potent aquatic antimicrobial compounds.…”

Section: Introductionmentioning

confidence: 99%

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Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Guo

Zhu

2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to perform bioassay-guided fractionation and identification of active substances against the aquatic pathogen Vibrio anguillarum from the fungus Aspergillus tubingensis SZX-6 associated with the crab Portunus trituberculatus. Based on the antibacterial activity against V. anguillarum, three compounds were isolated and purified from the culture broth of strain SZX-6 by sequential column chromatography over silica gel, Sephadex LH-20 and RP-18. The isolated compounds were identified on the basis of extensive spectroscopic data analysis. They were methyl 6-acetyl-5,7,8-trihydroxy-4-methoxy-2-naphthoate (1), daidzein (2) and genistein (3). Compound 1 showed moderate antibacterial activity against V. anguillarum (minimum inhibitory concentration 0.063 mg/mL). The obtained results could serve as a basis for further research towards design of active antibacterial agents against aquatic pathogens.

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“…africanus. [12] These reports illustrate the promising prospect of finding active compounds from marine microorganisms that act against aquatic pathogenic bacteria.…”

Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Guo

Zhu

2016

Biotechnology & Biotechnological Equipment

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“…Irobi et al (2000) worked on the A. quadrilineatus fungal species and found that these species have remarkable antimicrobial activity against S. aureus and B. subtilis; Niege et al (2002) showed that A. fumigatus have a remarkable antimicrobial activity against S. aureus, Candida albicans and Micrococcus luteus. Furthermore, Barakat and Gohar (2012) showed that A. terreus has a considerable antibacterial activity as compared to certain classic antibiotics; Al-Shaibani et al (2013) worked on the antibacterial activity of A. niger fungal species. The results revealed that this species has an inhibitory effect against P. aeruginosa, S. aureus, S. epidermidis, and Bacillus sp.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity of Aspergillus isolated from different Algerian ecosystems

Bramki¹,

Sana²,

Jaouani³

et al. 2017

Afr. J. Biotechnol.

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Thirty two strains of Aspergillus genus were isolated from soil samples obtained from particular ecosystems: Laghouat endowed with a desert climate and Teleghma with a warm and temperate climate. Based on the morphological aspect, this collection was subdivided into ten phenotypic groups. This identification was confirmed by molecular analyzes using a molecular marker of the genu ribosomal 18s. This marker will allow us to associate our sequences with those of known organisms. In order to discover new antibiotic molecules, the antibacterial activity was performed against two Gram positive bacteria: Staphylococcus aureus and Bacillus subtilis and also two Gram-negative bacteria: Escherichia coli and Pseudomonas aeroginosa, using two different techniques: Agar cylinders and disks technique. The results show that the fungal species have an activity against at least one test bacterium. The Gram positive bacteria were the most affected, where the averages of the inhibition zones reach 34.33 mm. However, Gram-negative bacteria showed less important results from 0 to 12.00 mm. It is recorded that the antibacterial activity was studied for the first time in the following two species: Aspergillus niveus and Aspergillus wentii. Furthermore, an indepth study is underway on bioguided fractionation, which would identify individual components and lead to the isolation of the active ingredient.

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“…The species has been reported from marine and associated habitats, such as mangroves and soft corals, and isolates from these habitats have been widely investigated for the production of bioactive compounds [40-42]. A. terreus has also been isolated from the hypersaline water of the Dead Sea [43,44].…”

Section: Discussionmentioning

confidence: 99%

Dissimilatory nitrate reduction by Aspergillus terreus isolated from the seasonal oxygen minimum zone in the Arabian Sea

et al. 2014

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BackgroundA wealth of microbial eukaryotes is adapted to life in oxygen-deficient marine environments. Evidence is accumulating that some of these eukaryotes survive anoxia by employing dissimilatory nitrate reduction, a strategy that otherwise is widespread in prokaryotes. Here, we report on the anaerobic nitrate metabolism of the fungus Aspergillus terreus (isolate An-4) that was obtained from sediment in the seasonal oxygen minimum zone in the Arabian Sea, a globally important site of oceanic nitrogen loss and nitrous oxide emission.ResultsAxenic incubations of An-4 in the presence and absence of oxygen and nitrate revealed that this fungal isolate is capable of dissimilatory nitrate reduction to ammonium under anoxic conditions. A 15N-labeling experiment proved that An-4 produced and excreted ammonium through nitrate reduction at a rate of up to 175 nmol 15NH4+ g-1 protein h-1. The products of dissimilatory nitrate reduction were ammonium (83%), nitrous oxide (15.5%), and nitrite (1.5%), while dinitrogen production was not observed. The process led to substantial cellular ATP production and biomass growth and also occurred when ammonium was added to suppress nitrate assimilation, stressing the dissimilatory nature of nitrate reduction. Interestingly, An-4 used intracellular nitrate stores (up to 6–8 μmol NO3- g-1 protein) for dissimilatory nitrate reduction.ConclusionsOur findings expand the short list of microbial eukaryotes that store nitrate intracellularly and carry out dissimilatory nitrate reduction when oxygen is absent. In the currently spreading oxygen-deficient zones in the ocean, an as yet unexplored diversity of fungi may recycle nitrate to ammonium and nitrite, the substrates of the major nitrogen loss process anaerobic ammonium oxidation, and the potent greenhouse gas nitrous oxide.

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Antimicrobial Agents Produced by Marine Aspergillus terreus var. africanus Against Some Virulent Fish Pathogens

Cited by 17 publications

References 32 publications

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Antibacterial activity of Aspergillus isolated from different Algerian ecosystems

Dissimilatory nitrate reduction by Aspergillus terreus isolated from the seasonal oxygen minimum zone in the Arabian Sea

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