Antimicrobial Adjuvants- An Innovative Strategy for Handling Antimicrobial Resistance Displayed by Microbes

Zaheer, Zaytoon; Rahman, Sajjad Ur; Zaheer, Iqra; Younas, Tayyaba; Abbas, Ghazanfar; Zaheer, Tean

doi:10.15406/jbmoa.2017.05.00144

Cited by 3 publications

(2 citation statements)

References 15 publications

(9 reference statements)

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“…For instance, an integrated approach to managing clinical infections that features the use of alternative ways to curb severe clinical symptoms. The use of anti-microbial adjuvants, nanomedicine and other easily biodegradable options for blocking resistance mechanisms may help counter the superbugs at initial stages [69,72].…”

Section: Prevention and Future Prospectivesmentioning

confidence: 99%

Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria

Hussain

Aqib

Seleem

et al. 2021

Microbial Pathogenesis

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Antibiotic-resistant bacteria are considered one of the major global threats to human and animal health. The most harmful of the resistant bacteria are β-lactamases producing Gram-negative species (β-lactamases). β-lactamases constitute a paradigm shift in the evolution of antibiotic resistance. Therefore, it is imperative to present a comprehensive review of the mechanisms responsible for the development of antimicrobial resistance. Resistance due to β-lactamases develops through to a variety of mechanisms, and the number of resistant genes is involved that can be transferred between bacteria, mostly via plasmids. Over time, these new molecular based resistance mechanisms have been progressively disclosed. The present review article provides information on the recent findings regarding the molecular mechanisms of resistance to β-lactams in Gram-negative bacteria, including CTX-M-type ESBLs with methylase activity, plasmids harbouring phages with β-lactam resistance genes, the co-presence of β-lactam resistant genes of unique combinations and the presence of β-lactam and non-β-lactam antibiotic-resistant

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Section: Prevention and Future Prospectivesmentioning

confidence: 99%

Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria

Hussain

Aqib

Seleem

et al. 2021

Microbial Pathogenesis

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“…Similarly, for those antibiotics showing toxicity issues, adjuvants can allow for administration at lower doses, therefore diminishing the side effects [ 20 ]. In addition, such targets, being not essential for survival per se, are less likely to generate mutations and therefore induce resistance [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants

et al. 2021

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Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents one of the most menacing threats to public health worldwide. The biosynthetic machinery required to synthesise L-cysteine is absent in mammals; therefore, its exploitation as a drug target is particularly promising. In this article, we report a series of inhibitors of Salmonella thyphimurium serine acetyltransferase (SAT), the enzyme that catalyzes the rate-limiting step of L-cysteine biosynthesis. The development of such inhibitors started with the virtual screening of an in-house library of compounds that led to the selection of seven structurally unrelated hit derivatives. A set of molecules structurally related to hit compound 5, coming either from the original library or from medicinal chemistry efforts, were tested to determine a preliminary structure–activity relationship and, especially, to improve the inhibitory potency of the derivatives, that was indeed ameliorated by several folds compared to hit compound 5 Despite these progresses, at this stage, the most promising compound failed to interfere with bacterial growth when tested on a Gram-negative model organism, anticipating the need for further research efforts.

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Antimicrobial Adjuvants - A Novel Approach to Manage Antimicrobial Resistance

Patel¹,

Acharya²,

Priyanka³

2021

AIA

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: Antibiotic resistance is one of the most prevalent, complex and serious global health issues, and needs to be monitored and controlled with medicine. Many approaches have been used to reduce the emergence and impact of resistance to antibiotics. The antimicrobial adjuvant approach is considered as a novel, more effective and less expensive. The said approach not only suppresses the emergence of resistance but also conserves the activity of existing antibiotics by offering a promising strategy that is also complementary to the discovery of new antibiotics. This review contains an outline of the basic types of antibiotic adjuvant, their structure, the basis of their operation, their substrate antibiotics and the challenges in this field, as well as the role of potential compounds, namely β-lactamase inhibitors, efflux pump inhibitors and permeability enhancers in antibiotic resistance and their possible solutions.

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Antimicrobial Adjuvants- An Innovative Strategy for Handling Antimicrobial Resistance Displayed by Microbes

Cited by 3 publications

References 15 publications

Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria

Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria

Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants

Antimicrobial Adjuvants - A Novel Approach to Manage Antimicrobial Resistance

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