Antimicrobial activity of three investigational oral cephalosporins (BK-218, cefdinir, and RU29246) against Legionella

Antimicrobial activity of RU29246 (HR916 metabolite) compared with four other oral beta-lactams tested against more than 5000 clinical isolates

“…668). These studies also demonstrated that RU29246 had limited or no activity against Enterobacteriaceae producing stably derepressed type 1 cephalosporinases, Pseudomonas, Achromobacter, Flavobacterium, Listeria and Legionella (8,9). The multicenter study reported here extends these data, comparing the activity of RU29246 with that of four oral beta-lactam antibiotics ( Staphylococcus epidermidis…”

Cefdinir: An Expanded-Spectrum Oral Cephalosporin

“…and Clostridium spp. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Minimum bactericidal concentrations (MBCs) are usually less than four times the MICs, although some exceptions to this generalization exist. 10, 13 Human serum and urine do not affect cefdinir MIC or MBC values.…”