Antimicrobial activity of RU29246 (HR916 metabolite) compared with four other oral beta-lactams tested against more than 5000 clinical isolates

Abstract

The activity of RU29246, the active metabolite of the oral cephalosporin ester HR916, was compared in a multicenter study with that of the four oral beta-lactam antibiotics cephalexin, cefaclor, cefixime and amoxicillin/clavulanate (amoxicillin/CA). RU29246 was generally 2- to 8-fold more active than the other oral cephalosporins and comparable to amoxicillin/CA against staphylococci, and was the most active cephalosporin against group B streptococci. All four cephalosporins were ineffective against enterococci. RU29246 was the only cephalosporin consistently active against Acinetobacter, but all beta-lactam antibiotics had poor activity against Pseudomonas spp. and Xanthomonas maltophilia. RU29246 was comparable to cefixime and more active than the other cephalosporins against members of the family Enterobacteriaceae. However, all of the antibiotics had poor activity against Enterobacter cloacae and Serratia marcescens. Quality control reference ranges for the quality control organisms Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922 are proposed for the broth dilution method based on data derived from this multicenter study.

Pharmaco bacteriological investigation of erythromycin, cephalexin, cephradine, amoxycillin and ciprofloxacin against different strains of klebsiella pneumonaie, escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and salmonella species

“…Staphylococcus aureus strains were susceptible to cephalexin in-vitro 41 and this findings is in agreement with the result of this study. Also all strains of Staphylococcus aureus were found to be susceptible (sensitive and moderately sensitive) to cephalexin and cephradine at concentrations ranging between 3.125 µg/m -50 µg/ml.…”

Effect of green tea on the effectiveness of Cefixime on Escherichia coli and Pseudomonas aeruginosa bacteria

“…Like all beta-lactam antibiotics, cefixime ability to interfere with PBP-mediated cell wall synthesis ultimately leads to cell lysis. (19) In this research a study of the effect of phenolic compounds extracted from green tea interpenetrating with drug cefixime against the bacteria Pseudomonas aeruginosa, Escherichia coli gives an idea of the overlap between each of them as the results showed that the drug cefixime gives high inhibitory effect in the bacterial species under study these results were in agreement with other studies (20,21) which mentioned that the drug cefixime has a strong activity against gramnegative bacteria like Pseudomonas aeruginosa, Escherichia coli while this result disagreement with (3,22,23) which find that the cefixime is inactive against Pseudomonas aeruginosa. before adding the phenolic extracts which was different influence in these types of bacteria but was less effective than drug cefixime which inhibits the growth of bacteria in lowest concentration This drug may be exert its effect by interfering with the structural cross linking of peptidoglycans in bacterial cell walls.…”

Comparative Antibacterial Activity of the Aminothiazolyl Cephalosporin RU 29 246

“…This stability is responsible for the ex cellent in vitro activity of this compound against many gram-negative and gram-posi tive bacteria. Jones et al [5,6] were also resistant to imipenem. On the other hand, only 5 isolates of E. cloacae were resist ant to this cephem as compared with 9 for imi penem.…”