Antimicrobial Activity of the Crude Extracts of Hamelia patens on Some Selected Clinical Samples

Okoye, Ebele Linda; Ezeogo, J. I.

doi:10.9734/jocamr/2016/27258

Cited by 3 publications

(3 citation statements)

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“…The maximum anti-bacterial property was found in ethanolic extract of leaves and stem where the Minimum Bactericidal Concentration (MBC) ranged from 25 mg/ml to > 100 mg/ml among the test organisms Staphylococcus aureus, Escherichia coli, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa and Minimum Inhibitory Concentration (MIC) ranged from 12.5 mg/ml to 100 mg/ml. While petroleum ether extract shows the least antibacterial activity [42]. Silver nanoparticles from Hamelia patens extract to inhibit the growth of Salmonella ebony, Bacillus subtilis, Klebsiella pneumonia, and Pseudomonas aeruginosa.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens

et al. 2020

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The world health organization reports that 80% of the population living within the developing countries depends basically on traditional medicine for his or her primary health care. Quite half the entire world's population still depends entirely on plants for medicines, and plants provides the active ingredients to the most traditional medical products. Hamelia patens that belong to the family Rubiaceae, is mainly found in tropical and sub-tropical areas. It is used in folk medicine against a wide range of diseases such as athlete’s foot, skin problems, insect sting, psychiatric disorder, rheumatism, headache, asthma, dysentery, menses, ovarian and uterine disorders. Hamelia consists of an important bioactive constituent such as oxindole alkaloids, flavonoids, and phenolic content. Due to the presence of chlorogenic acid and epicatechin constituent in the methanolic extract of Hamelia patens, there is a noticeable anti-hyperglycemic activity as well as it possesses antioxidant activity. Acute and sub-acute toxicity study has been performed on Hamelia patens which shows that it is safe and can be used for humans. Against fungi and bacteria, the ethanol leaf extract of Hamelia has a maximum inhibitory effect. The plant has various therapeutic effects like anti-inflammatory, analgesic, anti-diarrheal, anthelmintic, antidepressant, hepatoprotective, antiurolithiatic, diuretic, wound healing, and many others. In this article, we have discussed chemical constituent, pharmacological activity and traditional use of Hamelia patens.

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Section: Antidiabetic Activitymentioning

confidence: 99%

A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens

et al. 2020

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“…It is important to highlight the results of S. aureus against the four extracts since this microorganism is involved in most nosocomial infections. In addition, the resistance to many antibiotics by this microorganism has been pointed out in numerous cases [15], which at some point could cause the results obtained to be applied.…”

Section: Discussionmentioning

confidence: 99%

Assessment of antimicrobial activity in Diplostephium phylicoides and Diplostephium revolutum extracts by plates and wells method

Palacios¹

2019

Asian J Pharm Clin Res

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Abstract. In the present work, the evaluation of the antimicrobial activity of Diplostephium phylicoides and Diplostephium revolutum on different microorganisms was carried out on using bacteria such as Escherichia coli (CMPUJ:034), Staphylococcus aureus (CMPUJ:370), Salmonella typhi (CMPUJ:045) and Pseudomonas aeruginosa (CMPUJ:065), yeasts such as Saccharomyces cerevisiae (CMPUJ:H042) and Candida albicans (CMPUJ:H022), and filamentous fungi such as Penicillium chrysogenum (CMPUJ:H061) and Aspergillus niger (CMPUJ:H002). This assessment was made by the method of plates and wells using extracts from the leaves of the previously mentioned plants. The extracts were made with different solvents, ethanol, ethyl acetate, dichloromethane and petroleum ether. The results showed that the ethyl acetate extract of Diplostephium phylicoides has antimicrobial activity against Staphylococcus aureus and Candida albicans; furthermore, the dichloromethane extract showed an inhibitory effect against Saccharomyces cerevisiae. When comparing the extracts of the two plants, under the evaluated conditions, the extracts presented antimicrobial activity, and the ethyl acetate extract of Diplostephium revolutum the one that showed better activity against all the microorganisms.

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“…Hamelia patens is among the most extensively studied genera within the Rubiaceae family due to its reported antihyperglycemic effect [38][39][40]. Various extracts derived from distinct parts of the plant have shown a wide range of activities, including antimicrobial [41][42][43], anti-inflammatory [39,41], antioxidant [44], antidepressant [45], antinociceptive [46], hepatoprotective [47], and cytotoxic activities [48,49]. Several metabolites have been isolated from H. patens, including flavonoids, terpenoids, coumarins, sterols, and anthocyanins [50].…”

Section: Plants From the Rubiaceae Family For Treating Mets: Hamelia Sppmentioning

confidence: 99%

Plants of the Rubiaceae Family with Effect on Metabolic Syndrome: Constituents, Pharmacology, and Molecular Targets

González-Castelazo,

Soria-Jasso,

Torre-Villalvazo

et al. 2023

Plants

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Metabolic syndrome (MetS) predisposes individuals to chronic non-communicable diseases (NCDs) like type 2 diabetes (T2D), non-alcoholic fatty liver disease, atherosclerosis, and cardiovascular disorders caused by systemic inflammation, intestinal dysbiosis, and diminished antioxidant ability, leading to oxidative stress and compromised insulin sensitivity across vital organs. NCDs present a global health challenge characterized by lengthy and costly pharmacological treatments. Complementary and alternative medicine using herbal therapies has gained popularity. Approximately 350,000 plant species are considered medicinal, with 80% of the world’s population opting for traditional remedies; however, only 21,000 plants are scientifically confirmed by the WHO. The Rubiaceae family is promissory for preventing and treating MetS and associated NCDs due to its rich content of metabolites renowned for their antioxidative, anti-inflammatory, and metabolic regulatory properties. These compounds influence transcription factors and mitigate chronic low-grade inflammation, liver lipotoxicity, oxidative stress, and insulin resistance, making them a cost-effective non-pharmacological approach for MetS prevention and treatment. This review aims to collect and update data that validate the traditional uses of the Rubiaceae family for treating MetS and associated NCDs from experimental models and human subjects, highlighting the mechanisms through which their extracts and metabolites modulate glucose and lipid metabolism at the molecular, biochemical, and physiological levels.

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Antimicrobial Activity of the Crude Extracts of Hamelia patens on Some Selected Clinical Samples

Cited by 3 publications

References 0 publications

A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens

A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens

Assessment of antimicrobial activity in Diplostephium phylicoides and Diplostephium revolutum extracts by plates and wells method

Plants of the Rubiaceae Family with Effect on Metabolic Syndrome: Constituents, Pharmacology, and Molecular Targets

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