Dementia is a neurodegenerative condition that is considered a major factor contributing to cognitive decline that reduces independent function. Pathophysiological pathways are not well defined for neurodegenerative diseases such as dementia; however, published evidence has shown the role of numerous inflammatory processes in the brain contributing toward their pathology. Microglia of the central nervous system (CNS) are the principal components of the brain’s immune defence system and can detect harmful or external pathogens. When stimulated, the cells trigger neuroinflammatory responses by releasing proinflammatory chemokines, cytokines, reactive oxygen species, and nitrogen species in order to preserve the cell’s microenvironment. These proinflammatory markers include cytokines such as IL-1, IL-6, and TNFα chemokines such as CCR3 and CCL2 and CCR5. Microglial cells may produce a prolonged inflammatory response that, in some circumstances, is indicated in the promotion of neurodegenerative diseases. The present review is focused on the involvement of microglial cell activation throughout neurodegenerative conditions and the link between neuroinflammatory processes and dementia.
Alpinia galanga plant which is associated with family Zingiberaceae is mainly scattered in tropical areas and widely known for ethno medicine. Against fungi and bacteria rhizome extract have a maximum inhibitory effect. Alpinia galanga plant is used in medicine and in food preparation. Rhizome extract of Alpinia galanga have high phenolic and flavonoid contents when compared to leaf extract. Because of elevated phenolic and flavonoid content in rhizome extract of Alpinia galanga there is noticeable antimicrobial as well as radical scavenging potential. It is a well-known official drug thought out the country as integrated contribution of nature. It is commonly used for the management of eczema, coryza, bronchitis, otitis interna, gastritis, ulcers, morbilli and cholera, pityriasis versicolor, to clear the mouth, emaciation. The different parts of the plant have various effects like antifungal, antiprotozoal, antiplatelet, antiviral, antidiabetic, immunomodulatory, antibacterial, anti-oxidant effects, hypolipidemic and many others. The essential oil of A. galanga identified 1, 8-cineol as a bioactive agent having antifeeding activity. An aqueous acetone extract of fruit of Alpinia galanga shows inhibitory effect on melanogenesis (formation of melanin). By using different methods, active constituent namely, 1'-acetochavicol acetate in hexane extract of Alpinia galanga rhizome was investigated for their corrosion inhibition properties. The current review add significant information about its, pharmacological activities, medicinal properties and phytochemical investigations as a traditional drug to cure for a number of diseases. Every fraction of the plant has valuable properties that can deliver humanity. The complete plant will be broadly investigated for further future prospective.
Epilepsy is a syndrome specified by frequent seizures and is one of the most prevalent neurological conditions, and that one-third of people of epilepsy are resistant to available drugs. Surgery is supposed to be the main treatment for the remedy of multiple drug-resistant epilepsy, but it is a drastic procedure. Advancement in genomic technologies indicates that gene therapy can make such surgery unnecessary. The considerable number of new studies show the significance of mutation in mammalian target of rapamycin pathway, NMDA receptors, GABA receptors, potassium channels and G-protein coupled receptors. Illustration of the meticulous drug in epilepsy targeting new expression of mutations in SCN8A, GRIN2A, GRIN2D and KCNT1 are conferred. Various methods are utilized to express a gene in a precise area of the brain; Transplantation of cells in an ex vivo approach (fetal cells, fibroblasts, immortalized cells), nonviral vector delivery and viral vector delivery like retrovirus, herpes simplex virus adenovirus and adeno-related virus. Gene therapy has thus been explored to generate anti-epileptogenic, anti-seizure and disease-modifying effects. Specific targeting of the epileptogenic region is facilitated by gene therapy, hence sparing the adjacent healthy tissue and decreasing the adverse effects that frequently go hand in hand with antiepileptic medication.
The world health organization reports that 80% of the population living within the developing countries depends basically on traditional medicine for his or her primary health care. Quite half the entire world's population still depends entirely on plants for medicines, and plants provides the active ingredients to the most traditional medical products. Hamelia patens that belong to the family Rubiaceae, is mainly found in tropical and sub-tropical areas. It is used in folk medicine against a wide range of diseases such as athlete’s foot, skin problems, insect sting, psychiatric disorder, rheumatism, headache, asthma, dysentery, menses, ovarian and uterine disorders. Hamelia consists of an important bioactive constituent such as oxindole alkaloids, flavonoids, and phenolic content. Due to the presence of chlorogenic acid and epicatechin constituent in the methanolic extract of Hamelia patens, there is a noticeable anti-hyperglycemic activity as well as it possesses antioxidant activity. Acute and sub-acute toxicity study has been performed on Hamelia patens which shows that it is safe and can be used for humans. Against fungi and bacteria, the ethanol leaf extract of Hamelia has a maximum inhibitory effect. The plant has various therapeutic effects like anti-inflammatory, analgesic, anti-diarrheal, anthelmintic, antidepressant, hepatoprotective, antiurolithiatic, diuretic, wound healing, and many others. In this article, we have discussed chemical constituent, pharmacological activity and traditional use of Hamelia patens.
In the last few decennaries, dementia has emerged as a serious encyclopaedic ailment. Alzheimer’s disease is an ordinary type of dementia. In spite of considerable drug research, there is only a limited number of drugs approved for dementia. However, they only provide symptomatic relief and are frequently associated with adverse effects and side effects. Therefore, there is a need for developing a replacement point of view to dementia. In recent times, the use of herbal products has increased tremendously around the world. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseased conditions of the brain, viz. Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc. These smart drugs enhance cognitive performance by increasing attentiveness, creativity, etc. and thus improving the quality of life. A variety of medicinal plants show memory-enhancing properties by virtue of their chemical constituents. There has been a considerable pharmacological investigation into the memory-enhancing activity of some compounds. The plants in 'Ayurveda' were widely used for memory impairment management in numbers viz. Mandookparni (Centella asiatica), Shankhpushpis (Convolvulus pluricaulis), Malhuyesthi (Glycyrrhiza glabra), Guduchi (Tinospora cordifolia), and Brahmi (Bacopa monnieri). As a result, this study provides a comprehensive look into natural herbal medications for dementia, their mechanisms, as well as in-vitro and in-vivo memory improving models.Diverse studies have agreed that the enrollment of herbal plants is a revolutionary project for the research and development of curatives that are highlighted in this report and their ethnomethodology suitability.
: Worldwide health and therapeutic practices seek to amalgamate alternative medications with evidence-based medicine for an improved understanding of metabolic progression and its influences on the human body. Actinidia deliciosa, also known as “Kiwi fruit”, is a dioecious plant that is native to China and distributed widely across the Asian continent. Commercial planting of kiwifruit was started in the early 20th century when it reached New Zealand from China. In recent times, Kiwi fruit has gained a major demand due to its high content of vitamin C. Kiwi fruit also contains dietary fiber, iron, carotenoids and is a rich source of antioxidants. These may aid in lowering blood pressure, improve wound healing, blood glucose control and improve bowel health. Vitamin C, choline, lutein, and zeaxanthin are antioxidants that assist in the removal of free radicals from the body and may prevent the body from various diseases and inflammations. Herein, we state the health benefits found in diverse compounds from Actinidia deliciosa, highlighting the source, morphology, chemical constituent, cultivation, production, traditional uses, nutritional value, health benefits, toxicity studies, clinical trials, and pharmacological activities while highlighting side effects associated with kiwifruit. This review provides a bird’s eye insight mainly on the morphological, phytochemical, and pharmacological activity, which could be beneficial in making use of technological and scientific advances. This plant can be used as a current medical adjuvant for its potential. The complete plant must be broadly investigated for further future perspective.
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